Polr2a Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Polr2a
polymerase (RNA) II (DNA directed) polypeptide A
MGI:98086

69 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Braf^tm1Mmcm/Braf⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺ involves: 129P2/OlaHsd * C57BL/6 * SJL	increased lung adenoma incidence	J:121715
Braf^tm1Sva/Braf^tm1Sva Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} involves: 129S1/Sv * 129X1/SvJ	decreased cell proliferation	J:172200
Braf^tm1Sva/Braf^tm1Sva Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} Raf1^tm2Bacc/Raf1^tm2Bacc involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	decreased cell proliferation	J:172200
Braf^tm1Sva/Braf^tm1Sva Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} Raf1^tm2Bacc/Raf1^tm2Bacc involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	no abnormal phenotype detected	J:172200
Cdc20^tm1.1Mama/Cdc20^tm1.2Mama Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺ involves: 129/Sv * BALB/cJ * C57BL/6 * CD-1 * SJL	abnormal epidermis stratum basale morphology	J:167609
	abnormal intestinal epithelium morphology	J:167609
	abnormal mitosis	J:167609
	decreased cell proliferation	J:167609
	decreased tumor growth/size	J:167609
	delayed hair regrowth	J:167609
	premature death	J:167609
	tumor regression	J:167609
	weight loss	J:167609
Cdk2^tm1Sgo/Cdk2^tm1Sgo Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} involves: 129S1/Sv * 129X1/SvJ	decreased tumor incidence	J:161780
	premature death	J:161780
Cdk2^tm2Sgo/Cdk2^tm2Sgo Cdk4^tm2.1Bbd/Cdk4^tm2.1Bbd Polr2a^{tm1(cre/ERT2)Bbd}/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	decreased body size	J:125217
	normal hematopoietic system phenotype	J:125217
	increased susceptibility to autoimmune diabetes	J:125217
	normal liver/biliary system phenotype	J:125217
Cdk2^tm2Sgo/Cdk2^tm2Sgo Kras^tm1Bbd/Kras^tm2Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} involves: 129S1/Sv * 129X1/SvJ	decreased tumor incidence	J:161780
	premature death	J:161780
Cdk4^tm2.1Bbd/Cdk4^tm2.1Bbd Kras^tm1Bbd/Kras^tm2Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} involves: 129S1/Sv * 129X1/SvJ	decreased cell proliferation	J:161780
	decreased tumor growth/size	J:161780
	early cellular replicative senescence	J:161780
	increased adenocarcinoma incidence	J:161780
Cdk4^tm2.2Bbd/Cdk4^tm2.1Bbd Kras^tm1Bbd/Kras^tm2Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} involves: 129S1/Sv * 129X1/SvJ	decreased cell proliferation	J:161780
	decreased tumor growth/size	J:161780
	decreased tumor incidence	J:161780
	early cellular replicative senescence	J:161780
	increased tumor incidence	J:161780
Cdk4^tm2.2Bbd/Cdk4^tm2.2Bbd Kras^tm1Bbd/Kras^tm1Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} involves: 129S1/Sv * 129X1/SvJ	decreased tumor incidence	J:161780
Cdk6^tm1Bbd/Cdk6^tm1Bbd Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} involves: 129S1/Sv * 129X1/SvJ	increased adenoma incidence	J:161780
	increased lung non-small cell carcinoma incidence	J:161780
	premature death	J:161780
Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp E4f1^tm1Pisc/E4f1^tm1.1Llca Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺ involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL	abnormal keratinocyte physiology	J:167157
	epidermal hyperplasia	J:167157
	hyperkeratosis	J:167157
E4f1^tm1Pisc/E4f1^tm1.1Llca Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺ involves: 129S4/SvJae * C57BL/6 * SJL	abnormal hair follicle bulge morphology	J:167157
	abnormal keratinocyte physiology	J:167157
	abnormal skin condition	J:167157
	abnormal skin morphology	J:167157
	abnormal skin physiology	J:167157
	absent epidermis stratum granulosum	J:167157
	absent suprabasal layer	J:167157
	alopecia	J:167157
	epidermal hyperplasia	J:167157
	hyperkeratosis	J:167157
	impaired wound healing	J:167157
	spontaneous skin ulceration	J:167157
	thick skin	J:167157
Ebf1^tm1.1Rug/Ebf1^tm1.1Rug Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺ involves: C57BL/6 * SJL	abnormal germinal center B cell physiology	J:182210
	arrested B cell differentiation	J:182210
	decreased B cell proliferation	J:182210
	decreased germinal center B cell number	J:182210
	decreased IgG1 level	J:182210
	decreased IgG3 level	J:182210
	decreased immature B cell number	J:182210
	decreased marginal zone B cell number	J:182210
	decreased pre-B cell number	J:182210
	decreased spleen germinal center number	J:182210
	decreased transitional stage B cell number	J:182210
	normal immune system phenotype	J:182210
	increased B cell apoptosis	J:182210
	increased B cell number	J:182210
Ebf1^tm1.1Rug/Ebf1^tm1.1Rug Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺ Tg(BCL2)#Wehi/0 involves: C57BL/6 * C57BL/6JWehi * SJL * SJL/JWehi	decreased immature B cell number	J:182210
	decreased pre-B cell number	J:182210
Fntb^tm1Bbd/Fntb^tm1.1Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL	abnormal hematopoietic system physiology	J:98944
	decreased cell proliferation	J:98944
	decreased incidence of tumors by chemical induction	J:98944
	delayed wound healing	J:98944
	small spleen	J:98944
Fntb^tm1Bbd/Fntb^tm1Bbd Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL	increased lung adenocarcinoma incidence	J:98944
	increased lung adenoma incidence	J:98944
Fntb^tm1Bbd/Fntb^tm1Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL	abnormal hematopoietic system physiology	J:98944
	decreased cell proliferation	J:98944
	decreased incidence of tumors by chemical induction	J:98944
	delayed wound healing	J:98944
	small spleen	J:98944
Kras^tm1Bbd/Kras⁺ Mapk14^tm1Nbr/Mapk14^tm2Nbr Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL	abnormal lung development	J:122397
	abnormal tumor incidence	J:122397
	enlarged lung	J:122397
	increased lung adenocarcinoma incidence	J:122397
	increased lung adenoma incidence	J:122397
	increased lung tumor incidence	J:122397
	premature death	J:122397
Kras^tm1Bbd/Kras⁺ Mapk14^tm2Nbr/Mapk14⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL	increased hemolymphoid system tumor incidence	J:122397
	increased lung adenoma incidence	J:122397
	increased lung tumor incidence	J:122397
	premature death	J:122397
Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} involves: 129S1/Sv * 129X1/SvJ	increased adenoma incidence	J:161780
	increased lung non-small cell carcinoma incidence	J:161780
	premature death	J:161780
Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} Raf1^tm2Bacc/Raf1^tm2Bacc involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	decreased cell proliferation	J:172200
Kras^tm1Bbd/Kras^tm2Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} involves: 129S1/Sv * 129X1/SvJ	increased cell proliferation	J:161780
	increased lung non-small cell carcinoma incidence	J:161780
	increased lung tumor incidence	J:161780
	premature death	J:161780
Map2k1^tm1Chrn/Map2k1^tm1Chrn Map2k2^tm1Chrn/Map2k2^tm1Chrn Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} involves: 129/Sv * C57BL/6J * SJL	abnormal crypts of Lieberkuhn morphology	J:172200
	abnormal intestine morphology	J:172200
	premature death	J:172200
Mapk1^tm1.1Hed/Mapk1^tm1.1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} involves: 129	premature death	J:172200
Mapk14^tm1Nbr/Mapk14^tm2Nbr Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL	abnormal lung development	J:122397
	abnormal tumor incidence	J:122397
	enlarged lung	J:122397
	increased lung adenocarcinoma incidence	J:122397
	increased lung adenoma incidence	J:122397
	increased lung tumor incidence	J:122397
	premature death	J:122397
Mapk14^tm2Nbr/Mapk14^tm2Nbr Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺ involves: 129 * C57BL/6 * CD-1 * SJL	abnormal cell cycle	J:122397
	abnormal lung epithelium morphology	J:122397
	abnormal lung morphology	J:122397
	abnormal pulmonary alveolus epithelial cell morphology	J:122397
	increased cell proliferation	J:122397
Mastl^tm1.1Mama/Mastl^tm1.1Mama Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺ Not Specified	abnormal embryonic neuroepithelium morphology	J:201971
	abnormal mitosis	J:201971
Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺ Rnf2^tm1Mvi/Rnf2^tm1Mvi involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10 * SJL	abnormal bone marrow cell morphology/development	J:130397
	abnormal common myeloid progenitor cell morphology	J:130397
	decreased B cell number	J:130397
Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} Raf1^tm2Bacc/Raf1^tm2Bacc involves: 129P2/OlaHsd	no abnormal phenotype detected	J:172200

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