69 phenotypes from 10 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ren1tm1.1Sig/Ren1tm1.1Sig Tg(GFAP-cre)25Mes/0 involves: C57BL/6J * FVB/N	normal cardiovascular system phenotype	J:168753
	normal homeostasis/metabolism phenotype	J:168753
	normal mortality/aging	J:168753
	normal renal/urinary system phenotype	J:168753
Ren1tm1.1Sig/Ren1tm1.1Sig Tg(Nes-cre)1Kln/0 involves: C57BL/6 * C57BL/6J * SJL	normal cardiovascular system phenotype	J:168753
	normal homeostasis/metabolism phenotype	J:168753
	normal mortality/aging	J:168753
	normal renal/urinary system phenotype	J:168753
Ren1tm1.2Sig/Ren1tm1.2Sig involves: C57BL/6J	abnormal baroreceptor physiology	J:169129
	decreased hematocrit	J:169129
	decreased mean systemic arterial blood pressure	J:169129
	decreased physiological sensitivity to xenobiotic	J:169129
	decreased urine osmolality	J:169129
	decreased vasoconstriction	J:169129
	increased circulating aldosterone level	J:169129
	kidney atrophy	J:169129
	polyuria	J:169129
	postnatal lethality, complete penetrance	J:169129
Ren1tm1Afu/Ren1tm1Afu involves: C57BL/6 * CBA	abnormal blood homeostasis	J:59299
	abnormal innervation	J:59299
	abnormal juxtaglomerular apparatus morphology	J:59299
	abnormal juxtaglomerular cell morphology	J:59299
	abnormal macula densa morphology	J:59299
	normal cardiovascular system phenotype	J:59299
	decreased circulating renin level	J:59299
	decreased systemic arterial blood pressure	J:59299
	decreased systemic arterial diastolic blood pressure	J:59299
	decreased systemic arterial systolic blood pressure	J:59299
	hydronephrosis	J:59299
	kidney atrophy	J:59299
	polydipsia	J:59299
	polyuria	J:59299
	postnatal lethality, complete penetrance	J:59299
	vascular smooth muscle hyperplasia	J:59299
Ren1tm1Bjm/Ren1tm1Bjm B6.Cg-Ren1tm1Bjm	abnormal locomotor behavior	J:117294
	abnormal macula densa morphology	J:117294
	normal cardiovascular system phenotype	J:117294
	decreased mean systemic arterial blood pressure	J:117294
	decreased renal glomerular filtration rate	J:117294
	decreased systemic arterial diastolic blood pressure	J:117294
	decreased systemic arterial systolic blood pressure	J:117294
	hypotension	J:117294
	increased circulating creatinine level	J:117294
	increased heart rate	J:117294
	normal nervous system phenotype	J:117294
Ren1tm1Gom/Ren1tm1Gom involves: 129S6/SvEvTac	abnormal juxtaglomerular cell morphology	J:72077
	decreased circulating renin level	J:72077
	decreased systemic arterial blood pressure	J:72077
Ren1tm1Mgfs/Ren1tm1Mgfs involves: 129P2/OlaHsd	abnormal blood homeostasis	J:41714
	abnormal juxtaglomerular cell morphology	J:41714
	abnormal macula densa morphology	J:41714
	decreased circulating renin level	J:41714
	decreased systemic arterial blood pressure	J:41714
Ren1tm1Tkh/Ren1+ C57BL/6-Ren1tm1Tkh	no abnormal phenotype detected	J:110082
Ren1tm1Tkh/Ren1tm1Tkh C57BL/6-Ren1tm1Tkh	abnormal kidney afferent arteriole morphology	J:110082
	abnormal kidney interlobular artery morphology	J:110082
	abnormal urine homeostasis	J:110082
	decreased body weight	J:110082
	decreased circulating angiotensin II level	J:110082
	decreased circulating renin level	J:110082
	decreased systemic arterial blood pressure	J:110082
	decreased urine osmolality	J:110082
	dehydration	J:110082
	glomerulosclerosis	J:110082
	granular kidney	J:110082
	hydronephrosis	J:110082
	increased blood urea nitrogen level	J:110082
	increased circulating creatinine level	J:110082
	kidney inflammation	J:110082
	kidney medulla atrophy	J:110082
	kidney papillary atrophy	J:110082
	kidney papillary hypoplasia	J:110082
	metabolic acidosis	J:110082
	polyuria	J:110082
	postnatal lethality, incomplete penetrance	J:110082
	renal interstitial fibrosis	J:110082
	normal reproductive system phenotype	J:110082
	small kidney	J:110082
Ren1tm3Gom/Ren1+ 129S6/SvEvTac-Ren1tm3Gom	abnormal juxtaglomerular cell morphology	J:95786
	decreased circulating renin level	J:95786
Ren1tm3Gom/Ren1tm3Gom 129S6/SvEvTac-Ren1tm3Gom	abnormal juxtaglomerular cell morphology	J:95786
	abnormal kidney cortex morphology	J:95786
	abnormal kidney medulla morphology	J:95786
	abnormal renal glomerulus morphology	J:95786
	decreased circulating renin level	J:95786
	decreased kidney weight	J:95786
	decreased systemic arterial blood pressure	J:95786
	dilated renal tubule	J:95786
	granular kidney	J:95786
	increased blood urea nitrogen level	J:95786
	increased circulating potassium level	J:95786
	kidney atrophy	J:95786
	kidney cortex atrophy	J:95786
	proximal convoluted tubule brush border loss	J:95786
	renal glomerulus atrophy	J:95786
	renal glomerulus fibrosis	J:95786
	renal glomerulus hypertrophy	J:95786
	renal interstitial fibrosis	J:95786
	renal tubule atrophy	J:95786
	small kidney	J:95786
Tg(Alb1-Ren)1Unc/0 involves: 129S6/SvEvTac * C57BL/6	albuminuria	J:89252
	decreased urine osmolality	J:89252
	hypertension	J:89252
	increased circulating creatinine level	J:89252
	kidney inflammation	J:89252
	polydipsia	J:89252
	polyuria	J:89252
Tg(Alb1-Ren)2Unc/? 129S6/SvEvTac-Tg(Alb1-Ren)2Unc	increased systemic arterial blood pressure	J:125933
Tg(Alb1-Ren)2Unc/0 involves: 129S6/SvEvTac * C57BL/6	albuminuria	J:89252
	cardiac hypertrophy	J:88650
	decreased heart rate	J:88650
	decreased urine osmolality	J:89252
	hypertension	J:88650, J:89252
	increased circulating creatinine level	J:89252
	kidney inflammation	J:89252
	polydipsia	J:89252
	polyuria	J:89252
	premature death	J:88650