About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Rb1
RB transcriptional corepressor 1
MGI:97874
176 phenotypes from 20 alleles in 37 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Ddx4tm1.1(cre)Dcp/Ddx4+
Rb1tm3Tyj/Rb1tm3Tyj
involves: 129S4/SvJae * C57BL/6
abnormal fertility/fecundity J:198777
abnormal spermatogenesis J:198777
decreased testis weight J:198777
male infertility J:198777
small testis J:198777
Rb1tm1.1Gfk/Rb1tm1.1Gfk
Tg(Tyr-cre)1Gfk/0
involves: 129T2/SvEms * C57BL/6 * SJL
abnormal melanocyte morphology J:108628
postnatal lethality, complete penetrance J:108628
Rb1tm1.1Jyjw/Rb1+
either: (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6) or (involves: 129S4/SvJae * 129S6/SvEvTac)
abnormal pilomotor reflex J:80087
decreased apoptosis J:80087
decreased retina apoptosis J:80087
decreased susceptibility to induced morbidity/mortality J:80087
lethargy J:80087
Rb1tm1.1Jyjw/Rb1tm1.1Jyjw
129S6.129-Trp53tm1Tyj Rb1tm1.1Jyjw
normal neoplasm J:102483
Rb1tm1.1Jyjw/Rb1tm1.1Jyjw
either: (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6) or (involves: 129S4/SvJae * 129S6/SvEvTac)
abnormal pilomotor reflex J:80087
abnormal retina apoptosis J:80087
decreased apoptosis J:80087
decreased susceptibility to induced morbidity/mortality J:80087
increased susceptibility to induced morbidity/mortality J:80087
lethargy J:80087
prenatal lethality, incomplete penetrance J:80087
Rb1tm1.2Gfk/Rb1+
involves: 129T2/SvEms * C57BL/6 * SJL
decreased tumor-free survival time J:108628
increased tumor incidence J:108628
Rb1tm1.2Gfk/Rb1tm1.2Gfk
involves: 129T2/SvEms * C57BL/6 * SJL
preweaning lethality, incomplete penetrance J:108628
Rb1tm1Brd/Rb1+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
increased pheochromocytoma incidence J:79016
increased pituitary adenohypophysis tumor incidence J:79016
increased pituitary melanotroph tumor incidence J:79016
increased thyroid C-cell carcinoma incidence J:79016
Rb1tm1Brd/Rb1+
involves: 129S7/SvEvBrd * C57BL/6
abnormal neuroendocrine gland morphology J:17434
cachexia J:17434
increased body mass index J:79648
increased brain tumor incidence J:2516
increased metastatic potential J:17434
increased pituitary adenoma incidence J:17434
normal neoplasm J:2516, J:79648
obese J:17434
Rb1tm1Brd/Rb1tm1Brd
involves: 129S7/SvEvBrd * C57BL/6
abnormal blood vessel morphology J:2516
abnormal brain morphology J:2516
abnormal cell proliferation J:2516
abnormal dorsal root ganglion morphology J:2516
abnormal embryo development J:2516
abnormal erythrocyte morphology J:2516
decreased brain size J:2516
decreased fetal size J:2516
decreased hepatocyte number J:2516
dilated liver sinusoidal space J:2516
edema J:2516
enlarged fourth ventricle J:2516
increased neuron apoptosis J:2516
increased nucleated erythrocyte cell number J:2516
kyphosis J:2516
lethality throughout fetal growth and development, complete penetrance J:2516
small dorsal root ganglion J:2516
small liver J:2516
normal vision/eye phenotype J:2516
Rb1tm1Brn/Rb1+
Tg(Pomc-FLP)1aBrn/0
involves: 129P2/OlaHsd * FVB/N
abnormal pituitary intermediate lobe morphology J:48860
increased pituitary adenoma incidence J:48860
Rb1tm1Brn/Rb1+
X/Tg(Pomc-FLP)1bBrn
involves: 129P2/OlaHsd * FVB/N
pituitary intermediate lobe hyperplasia J:48860
Rb1tm1Brn/Rb1tm1Brn
involves: 129P2/OlaHsd * FVB/N
no abnormal phenotype detected J:48860
Rb1tm1Brn/Rb1tm1Brn
Tg(Pomc-FLP)1aBrn/0
involves: 129P2/OlaHsd * FVB/N
increased pituitary adenoma incidence J:48860
premature death J:48860
Rb1tm1Brn/Rb1tm1Brn
X/Tg(Pomc-FLP)1bBrn
involves: 129P2/OlaHsd * FVB/N
decreased tumor-free survival time J:48860
increased pituitary adenoma incidence J:48860
pituitary intermediate lobe hyperplasia J:48860
Rb1tm1Dwg/Rb1tm1Dwg
involves: 129/Sv * C57BL/6
abnormal cell cycle J:105548
abnormal cell cycle checkpoint function J:105548
abnormal dorsal root ganglion morphology J:105548
abnormal erythropoiesis J:105548
abnormal fourth ventricle morphology J:105548
abnormal lens fiber morphology J:105548
abnormal macrophage morphology J:105548
abnormal placenta labyrinth morphology J:105548
abnormal placental transport J:105548
abnormal third ventricle morphology J:105548
abnormal trigeminal ganglion morphology J:105548
decreased embryo size J:105548
increased fibroblast proliferation J:105548
increased lens fiber apoptosis J:105548
lethality throughout fetal growth and development, complete penetrance J:105548
pallor J:105548
Rb1tm1Dwg/Rb1tm1Tyj
involves: 129/Sv * 129S2/SvPas * C57BL/6
abnormal erythropoiesis J:105548
decreased embryo size J:105548
lethality throughout fetal growth and development, complete penetrance J:105548
pallor J:105548
Rb1tm1Dwg/Rb1tm2Brn
Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
involves: 129/Sv * C57BL/6 * SJL
abnormal retina horizontal cell morphology J:105548
decreased retina rod cell number J:105548
Rb1tm1Fad/Rb1tm1Fad
involves: 129 * C57BL/6
abnormal chromosome morphology J:108366
abnormal milk ejection J:151417
abnormal mitosis J:108366
abnormal response/metabolism to endogenous compounds J:151417
aneuploidy J:108366
mammary gland duct hyperplasia J:151417
mammary gland hyperplasia J:151417
Rb1tm1Jyjw/Rb1+
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)
abnormal pilomotor reflex J:80087
abnormal retina apoptosis J:80087
decreased apoptosis J:80087
decreased susceptibility to induced morbidity/mortality J:80087
lethargy J:80087
Rb1tm1Jyjw/Rb1tm1Jyjw
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)
abnormal pilomotor reflex J:80087
decreased apoptosis J:80087
decreased retina apoptosis J:80087
decreased susceptibility to induced morbidity/mortality J:80087
increased susceptibility to induced morbidity/mortality J:80087
lethargy J:80087
prenatal lethality, incomplete penetrance J:80087
Rb1tm1Mlh/Rb1+
either: 129P2/OlaHsd-Rb1tm1Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
abnormal dorsal root ganglion morphology J:2498
increased pituitary melanotroph tumor incidence J:20542
normal neoplasm J:2498, J:20542
Rb1tm1Mlh/Rb1tm1Mlh
either: 129P2/OlaHsd-Rb1tm1Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
abnormal definitive hematopoiesis J:2498
abnormal dorsal root ganglion morphology J:2498
abnormal erythrocyte morphology J:2498
abnormal erythropoiesis J:2498, J:20542
abnormal frontal lobe morphology J:2498
abnormal lens fiber morphology J:20542
abnormal myelopoiesis J:2498
decreased erythrocyte cell number J:2498
decreased hepatocyte number J:20542
dilated fourth ventricle J:2498
dilated liver sinusoidal space J:2498
embryonic growth retardation J:2498
embryonic lethality, complete penetrance J:2498
flat forehead J:2498
increased apoptosis J:2498
increased megakaryocyte cell number J:2498
neurodegeneration J:2498, J:20542
pale yolk sac J:2498
normal vision/eye phenotype J:20542
Rb1tm1Tyj/Rb1+
involves: 129S2/SvPas
increased pituitary gland tumor incidence J:215358
postnatal lethality, incomplete penetrance J:215358
Rb1tm1Tyj/Rb1+
involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N
increased pituitary gland tumor incidence J:175625
increased thyroid tumor incidence J:175625
premature death J:175625
Rb1tm1Tyj/Rb1+
involves: 129S2/SvPas * C57BL/6
cachexia J:2511
increased pituitary gland tumor incidence J:2511, J:81082
increased thyroid tumor incidence J:81082
normal neoplasm J:2511
premature death J:81082
Rb1tm1Tyj/Rb1+
involves: 129S2/SvPas * C57BL/6J
increased lung tumor incidence J:133299
increased metastatic potential J:133299
increased pheochromocytoma incidence J:133299
increased pituitary adenohypophysis tumor incidence J:133299
increased pituitary melanotroph tumor incidence J:133299
increased thyroid C-cell carcinoma incidence J:133299
premature death J:133299
Rb1tm1Tyj/Rb1tm1Tyj
involves: 129S2/SvPas
abnormal cell cycle J:105548
abnormal cell cycle checkpoint function J:105548
abnormal dorsal root ganglion morphology J:105548
abnormal erythropoiesis J:105548
abnormal fourth ventricle morphology J:105548
abnormal lens development J:81643
abnormal lens fiber morphology J:105548
abnormal macrophage differentiation J:105548
abnormal neuron differentiation J:81643
abnormal placenta labyrinth morphology J:105548
abnormal placental transport J:105548
abnormal third ventricle morphology J:105548
abnormal trigeminal ganglion morphology J:105548
decreased embryo size J:105548
embryonic lethality during organogenesis, complete penetrance J:105548
hypoxia J:81643
increased fibroblast proliferation J:105548
increased lens fiber apoptosis J:105548
increased neuron apoptosis J:81643
increased nucleated erythrocyte cell number J:81643
liver hypoplasia J:81643
pallor J:105548
Rb1tm1Tyj/Rb1tm1Tyj
involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N
abnormal cell differentiation J:175625
embryonic lethality, complete penetrance J:175625
Rb1tm1Tyj/Rb1tm1Tyj
involves: 129S2/SvPas * C57BL/6
abnormal cartilage morphology J:37145
abnormal erythrocyte morphology J:2511
abnormal erythropoiesis J:2511
abnormal liver morphology J:2511
anemia J:2511
hunched posture J:37145
increased apoptosis J:37145
increased cell proliferation J:81082
increased neuron apoptosis J:2511
lethality throughout fetal growth and development, complete penetrance J:2511, J:81082
low mean erythrocyte cell number J:2511
normal nervous system phenotype J:92520
pericardial edema J:2511
skin edema J:2511
small liver J:2511
normal vision/eye phenotype J:2511
Rb1tm1Tyj/Rb1tm2Tyj
chimera involves: 129S2/SvPas * C57BL/6
abnormal hepatocyte morphology J:59268
abnormal Purkinje cell morphology J:59268
cachexia J:59268
cataract J:59268
ectopic Purkinje cell J:59268
increased pituitary adenoma incidence J:59268
normal nervous system phenotype J:59268
preneoplasia J:59268
thin cerebellar granule layer J:59268
normal vision/eye phenotype J:59268
Rb1tm2.1Brn/Rb1tm2.1Brn
Not Specified
lethality throughout fetal growth and development, complete penetrance J:77982
Rb1tm2.1Dwg/Rb1tm2.1Dwg
B6.129S4-Rb1tm2.1Dwg
no abnormal phenotype detected J:158408
Rb1tm2.1Fad/Rb1tm2.1Fad
involves: 129 * C57BL/6
normal cellular phenotype J:215358
normal digestive/alimentary phenotype J:215358
mammary gland duct hyperplasia J:215358
neonatal lethality, incomplete penetrance J:215358
normal neoplasm J:215358
normal nervous system phenotype J:215358
respiratory distress J:215358
skeletal muscle atrophy J:215358
Rb1tm2.1Jyjw/Rb1tm2.1Jyjw
involves: 129 * C57BL/6
abnormal milk ejection J:151417
abnormal response/metabolism to endogenous compounds J:151417
mammary gland duct hyperplasia J:151417
mammary gland hyperplasia J:151417
Rb1tm2Brn/Rb1tm2Brn
involves: 129
normal neoplasm J:86077, J:157319
normal respiratory system phenotype J:86077
Rb1tm2Brn/Rb1tm2Brn
involves: 129 * BALB/c
abnormal white adipose tissue morphology J:129672
Rb1tm2Brn/Rb1tm2Brn
Tg(Col1a1-cre)1Bek/0
involves: 129 * CD-1
abnormal hearing physiology J:96345
abnormal organ of Corti morphology J:96345
abnormal organ of Corti supporting cell proliferation J:96345
increased cochlear hair cell number J:96345
increased cochlear inner hair cell number J:96345
increased cochlear outer hair cell number J:96345
increased Deiters cell number J:96345
increased vestibular hair cell number J:96345
perinatal lethality J:96345
Rb1tm2Brn/Rb1tm2Brn
Tg(Cyp1a1-cre)1Dwi/0
involves: 129 * C57BL/6 * CBA
abnormal enterocyte proliferation J:215358
Rb1tm2Brn/Rb1tm2Brn
Tg(En2-cre)22Alj/0
involves: 129P2/OlaHsd * CD-1
abnormal brain interneuron morphology J:83783
abnormal cerebellar cortex morphology J:83783
abnormal cerebellar granule cell morphology J:83783
abnormal cerebellar granule layer morphology J:83783
abnormal cerebellum external granule cell layer morphology J:83783
abnormal neuronal precursor proliferation J:83783
abnormal Purkinje cell morphology J:83783
astrocytosis J:83783
increased neuron apoptosis J:83783
thin external granule cell layer J:83783
Rb1tm2Brn/Rb1tm2Brn
Tg(Gfap-cre)2Brn/0
involves: 129 * FVB/N
increased carcinoma incidence J:187257
increased pituitary gland tumor incidence J:187257
normal neoplasm J:61961
premature death J:187257
Rb1tm2Brn/Rb1tm2Brn
Tg(MMTV-cre)105Ayn/0
FVB.Cg-Rb1tm2Brn Tg(MMTV-cre)105Ayn
normal neoplasm J:165292
Rb1tm2Brn/Rb1tm2Brn
Tg(Myh6-cre)2182Mds/Tg(Myh6-cre)2182Mds
involves: 129 * FVB
no abnormal phenotype detected J:97589
Rb1tm2Brn/Rb1tm2Brn
Tg(Pcp2-cre)756Mro/0
involves: 129P2/OlaHsd * FVB
abnormal cerebellum vermis morphology J:83783
Rb1tm2Brn/Rb1tm2Brn
Tg(Pou4f3-cre)1Devet/0
involves: 129 * 129S/SvEv
abnormal cochlear hair cell morphology J:109453
abnormal cochlear outer hair cell morphology J:109453
abnormal organ of Corti morphology J:109453
abnormal organ of Corti supporting cell proliferation J:109453
abnormal vestibular hair cell morphology J:109453
abnormal vestibular system physiology J:109453
circling J:109453
cochlear hair cell degeneration J:109453
cochlear outer hair cell degeneration J:109453
deafness J:109453
impaired swimming J:109453
increased cochlear inner hair cell number J:109453
increased cochlear outer hair cell number J:109453
vestibular hair cell degeneration J:109453
Rb1tm2Brn/Rb1tm2Brn
Tg(Rbp3-cre)1Brn/0
involves: 129 * FVB/N
increased pituitary adenohypophysis tumor incidence J:77982
increased pituitary melanotroph tumor incidence J:77982
normal vision/eye phenotype J:77982
Rb1tm2Mlh/Rb1+
either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
abnormal dorsal root ganglion morphology J:2498
increased pituitary melanotroph tumor incidence J:20542
normal neoplasm J:2498, J:20542
Rb1tm2Mlh/Rb1tm2Mlh
either: 129P2/OlaHsd-Rb1tm2Mlh or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
abnormal definitive hematopoiesis J:2498
abnormal dorsal root ganglion morphology J:2498
abnormal erythrocyte morphology J:2498
abnormal erythropoiesis J:2498, J:20542
abnormal frontal lobe morphology J:2498
abnormal lens fiber morphology J:20542
abnormal myelopoiesis J:2498
decreased erythrocyte cell number J:2498
decreased hepatocyte number J:20542
dilated fourth ventricle J:2498
dilated liver sinusoidal space J:2498
embryonic growth retardation J:2498
embryonic lethality, complete penetrance J:2498
flat forehead J:2498
increased apoptosis J:2498
increased megakaryocyte cell number J:2498
neurodegeneration J:2498, J:20542
pale yolk sac J:2498
normal vision/eye phenotype J:20542
Rb1tm3Fad/Rb1tm3Fad
involves: 129S1/Sv * 129X1/SvJ
decreased tumor-free survival time J:249124
increased lymphoma incidence J:249124
Rb1tm3Tyj/Rb1tm3.1Tyj
Tg(Nes-cre)1Atp/0
involves: 129S4/SvJae * FVB/N
abnormal lens development J:81643
abnormal myogenesis J:81643
abnormal neuron differentiation J:81643
normal hematopoietic system phenotype J:81643
hunched posture J:81643
increased brain size J:81643
increased brain weight J:81643
increased neuron apoptosis J:81643
normal liver/biliary system phenotype J:81643
neonatal lethality, complete penetrance J:81643
Rb1tm3Tyj/Rb1tm3Tyj
involves: 129S4/SvJae
normal neoplasm J:172430
polyploidy J:172430
Rb1tm3Tyj/Rb1tm3Tyj
Tg(KRT14-cre)8Brn/0
involves: 129S4/SvJae * C57BL/6 * FVB
abnormal epidermis stratum granulosum morphology J:101623
abnormal epidermis suprabasal layer morphology J:101623
epidermal hyperplasia J:101623
Rb1tm3Tyj/Rb1tm3Tyj
Tg(Nes-cre)1Atp/0
involves: 129S4/SvJae * FVB/N
abnormal retina ganglion layer morphology J:91406
abnormal retina inner nuclear layer morphology J:91406
decreased retina photoreceptor cell number J:91406
decreased tumor-free survival time J:91406
disorganized retina inner nuclear layer J:91406
increased pituitary gland tumor incidence J:91406
increased retina apoptosis J:91406
thin retina outer nuclear layer J:91406
transmission ratio distortion J:91406
Rb1tm3Tyj/Rb1tm3Tyj
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S4/SvJae
abnormal retina inner nuclear layer morphology J:91406
abnormal retina inner plexiform layer morphology J:91406
abnormal retina morphology J:91406
absent retina bipolar cells J:91406
decreased retina ganglion cell number J:91406
gliosis J:91406
increased retina apoptosis J:91406
thin retina inner nuclear layer J:91406
thin retina inner plexiform layer J:91406
thin retina outer nuclear layer J:91406
Rb1tm3Tyj/Rb1tm3Tyj
Tg(Pax6-cre,GFP)2Pgr/0
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * FVB/N
abnormal retina morphology J:119919
increased retina apoptosis J:119919
Rb1tm3Tyj/Rb1tm3Tyj
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: 129S4/SvJae * C57BL/6J * CD-1
normal neoplasm J:136693

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/09/2024
MGI 6.23
The Jackson Laboratory