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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ptprc
protein tyrosine phosphatase receptor type C
MGI:97810
124 phenotypes from 22 alleles in 27 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ptprcloc/Ptprcloc
C57BL/6JSfdAnu-Ptprcloc/AnuApb 		abnormal B cell number J:104190
abnormal double-positive T cell morphology J:104190
abnormal memory T cell number J:104190
abnormal T cell morphology J:104190
abnormal T cell selection J:104190
abnormal thymocyte activation J:104190
arrested T cell differentiation J:104190
decreased CD4-positive, alpha-beta T cell number J:104190
decreased CD8-positive, alpha-beta T cell number J:104190
decreased double-positive T cell number J:104190
decreased T cell number J:104190
Ptprcltng/Ptprcltng
C57BL/6-Ptprcltng 		abnormal T cell differentiation J:158876
decreased CD4-positive, alpha-beta T cell number J:158876
decreased double-positive T cell number J:158876
thymus hypoplasia J:158876
Ptprcltng/Ptprctm1Mak
involves: 129/Sv * C57BL/6 		abnormal T cell differentiation J:158876
decreased CD4-positive, alpha-beta T cell number J:158876
decreased double-positive T cell number J:158876
thymus hypoplasia J:158876
Ptprcm1Btlr/Ptprcm1Btlr
involves: C57BL/6J 		absent T cells J:152064
Ptprcm1Smv/Ptprcm1Smv
involves: C57BL/6J * C57BL/10J 		abnormal CD4-positive T cell differentiation J:214487
abnormal CD8-positive, alpha-beta T cell differentiation J:214487
abnormal immune system cell morphology J:214487
abnormal immune system physiology J:214487
CNS inflammation J:214487
decreased DN4 thymocyte number J:214487
increased DN3 thymocyte number J:214487
increased double-negative T cell number J:214487
increased susceptibility to Herpesvirales infection J:214487
Ptprcm2Btlr/Ptprcm2Btlr
C57BL/6J-Ptprcm2Btlr 		abnormal humoral immune response J:216796
decreased B-1a cell number J:216796
decreased B-2 B cell number J:216796
decreased CD4-positive, alpha-beta memory T cell number J:216796
decreased CD8-positive, alpha-beta memory T cell number J:216796
decreased mature B cell number J:216796
decreased memory B cell number J:216796
decreased memory T cell number J:216796
decreased single-positive T cell number J:216796
increased B-1 B cell number J:216796
increased B-1b cell number J:216796
increased dendritic cell number J:216796
increased neutrophil cell number J:216796
increased single-positive T cell number J:216796
Ptprcm3Btlr/Ptprcm3Btlr
C57BL/6J-Ptprcm3Btlr 		decreased B cell number J:254899
decreased B-1a cell number J:254899
decreased B-2 B cell number J:254899
decreased CD8-positive, alpha-beta T cell number J:254899
increased B-1b cell number J:254899
Ptprcm4Btlr/Ptprcm4Btlr
C57BL/6J-Ptprcm4Btlr 		decreased B cell number J:264808
decreased CD4-positive, alpha-beta T cell number J:264808
decreased CD8-positive, alpha-beta T cell number J:264808
decreased CD8-positive, naive alpha-beta T cell number J:264808
decreased single-positive T cell number J:264808
decreased T cell number J:264808
increased B-1 B cell number J:264808
increased central memory CD4-positive, alpha-beta T cell number J:264808
increased central memory CD8 positive, alpha-beta T cell number J:264808
increased effector memory CD4-positive, alpha-beta T cell number J:264808
increased effector memory CD8-positive, alpha-beta T cell number J:264808
PtprcM5Btlr/PtprcM5Btlr
C57BL/6J-PtprcM5Btlr 		increased alpha-beta T cell number J:265143
PtprcM6Btlr/PtprcM6Btlr
C57BL/6J-PtprcM6Btlr 		decreased B-1a cell number J:265186
decreased B-1b cell number J:265186
decreased CD8-positive, naive alpha-beta T cell number J:265186
increased B-1 B cell number J:265186
Ptprcm7Btlr/Ptprcm7Btlr
C57BL/6J-Ptprcm7Btlr 		decreased alpha-beta T cell number J:267486
decreased B cell number J:267486
decreased CD4-positive, alpha-beta T cell number J:267486
decreased CD8-positive, alpha-beta T cell number J:267486
decreased CD8-positive, naive alpha-beta T cell number J:267486
decreased NK T cell number J:267486
increased B-1 B cell number J:267486
increased central memory CD4-positive, alpha-beta T cell number J:267486
increased central memory CD8 positive, alpha-beta T cell number J:267486
increased effector memory CD4-positive, alpha-beta T cell number J:267486
increased effector memory CD8-positive, alpha-beta T cell number J:267486
PtprcM8Btlr/PtprcM8Btlr
C57BL/6J-PtprcM8Btlr 		increased B-1 B cell number J:267487
increased central memory CD8 positive, alpha-beta T cell number J:267487
PtprcM9Btlr/PtprcM9Btlr
C57BL/6J-PtprcM9Btlr 		abnormal B cell differentiation J:272745
abnormal CD8-positive, alpha beta T cell morphology J:272745
abnormal lymphocyte morphology J:272745
decreased B cell number J:272745
decreased NK cell number J:272745
decreased systemic arterial systolic blood pressure J:272745
increased CD8-positive, alpha-beta T cell number J:272745
increased effector memory CD4-positive, alpha-beta T cell number J:272745
PtprcM10Btlr/PtprcM10Btlr
C57BL/6J-PtprcM10Btlr 		decreased B-1b cell number J:272777
decreased IgE level J:272777
PtprcM11Btlr/PtprcM11Btlr
C57BL/6J-PtprcM11Btlr 		abnormal B cell differentiation J:274863
abnormal CD8-positive, alpha-beta T cell differentiation J:274863
increased B-1 B cell number J:274863
Ptprcm12Btlr/Ptprcm12Btlr
C57BL/6J-Ptprcm12Btlr 		decreased B cell number J:274972
decreased CD4-positive, alpha-beta T cell number J:274972
decreased CD8-positive, alpha-beta T cell number J:274972
decreased CD8-positive, naive alpha-beta T cell number J:274972
decreased central memory CD8 positive, alpha-beta T cell number J:274972
decreased effector memory CD4-positive, alpha-beta T cell number J:274972
decreased T cell number J:274972
increased B-1 B cell number J:274972
Ptprcnim/Ptprcnim
C57BL/6JAnu-Ptprcnim 		decreased B cell number J:225105
decreased leukocyte cell number J:225105
decreased T cell number J:225105
Ptprcrain/Ptprcrain
C57BL/6JAnu-Ptprcrain/AnuApb 		abnormal leukocyte morphology J:104190
Ptprcstrm/Ptprcstrm
C57BL/6JAnu-Ptprcstrm/AnuApb 		decreased B cell number J:104190
decreased T cell number J:104190
Ptprctm1Holm/Ptprctm1Holm
involves: 129/Sv * C57BL/6 		abnormal B cell number J:33466
abnormal lymphopoiesis J:33466
abnormal T cell differentiation J:33466
decreased CD4-positive, alpha-beta T cell number J:33466
decreased CD8-positive, alpha-beta T cell number J:33466
decreased double-positive T cell number J:33466
decreased T cell number J:33466
decreased thymocyte number J:33466
increased double-negative T cell number J:33466
spleen hyperplasia J:33466
Ptprctm1Mak/Ptprctm1Mak
B6.Cg-Ptprctm1Mak 		abnormal CD4-positive, alpha-beta intraepithelial T cell morphology J:111646
abnormal intraepithelial T cell morphology J:111646
abnormal intraepithelial T cell number J:111646
abnormal NK cell physiology J:109462
abnormal T cell differentiation J:111646
decreased cytotoxic T cell cytolysis J:111646
decreased gamma-delta intraepithelial T cell number J:111646
increased T cell apoptosis J:111646
Ptprctm1Mak/Ptprctm1Mak
involves: 129 		abnormal bone marrow cell morphology/development J:141275
abnormal long bone metaphysis morphology J:141275
abnormal myelination J:104929
abnormal oligodendrocyte morphology J:104929
abnormal osteoclast morphology J:141275
abnormal osteoclast physiology J:141275
decreased mast cell degranulation J:110782
decreased oligodendrocyte number J:104929
decreased susceptibility to type I hypersensitivity reaction J:110782
Ptprctm1Mak/Ptprctm1Mak
involves: 129/Sv * C57BL/6 		abnormal response to infection J:13163
abnormal T cell subpopulation ratio J:13163
arrested T cell differentiation J:158876
decreased B cell proliferation J:13163
decreased CD4-positive, alpha-beta T cell number J:13163
decreased CD8-positive, alpha-beta T cell number J:13163
decreased cytotoxic T cell cytolysis J:13163
decreased T cell number J:13163
decreased T cell proliferation J:13163
decreased thymocyte number J:13163
increased double-negative T cell number J:13163
Ptprctm1Tyb/Ptprctm1Tyb
129S2/SvPas-Ptprctm1Tyb 		diarrhea J:57681
lethality at weaning, incomplete penetrance J:57681
Ptprctm1Tyb/Ptprctm1Tyb
B6.129S2-Ptprctm1Tyb 		abnormal chemokine secretion J:98190
abnormal cytokine secretion J:98190
abnormal NK cell physiology J:98190
increased NK cell number J:98190
Ptprctm1Tyb/Ptprctm1Tyb
C.129S2-Ptprctm1Tyb 		abnormal positive T cell selection J:57681
abnormal T cell differentiation J:57681
abnormal T cell physiology J:57681
decreased CD4-positive, alpha-beta T cell number J:57681
decreased CD8-positive, alpha-beta T cell number J:57681
decreased double-positive T cell number J:57681
enlarged spleen J:57681
normal hematopoietic system phenotype J:57681
normal immune system phenotype J:57681
increased double-negative T cell number J:57681
normal mortality/aging J:57681
thymus hypoplasia J:57681
Ptprctm1Tyb/Ptprctm1Tyb
involves: 129S2/SvPas * C57BL/6 * DBA/2 		no abnormal phenotype detected J:57681
Ptprctm1Weis/Ptprc+
involves: 129X1/SvJ * C57BL/6 		increased anti-double stranded DNA antibody level J:66501
increased IgG2a level J:66501
increased susceptibility to autoimmune disorder J:66501
increased urine protein level J:66501
premature death J:66501
Ptprctm1Weis/Ptprctm1Weis
B6.129X1-Ptprctm1Weis 		abnormal B cell activation J:147129
abnormal double-positive T cell morphology J:147129
abnormal follicular B cell physiology J:147129
abnormal T cell activation J:147129
abnormal T cell subpopulation ratio J:147129
abnormal thymocyte activation J:147129
decreased follicular B cell number J:147129
enlarged lymph nodes J:147129
normal immune system phenotype J:109462
increased memory T cell number J:147129
increased plasma cell number J:147129
increased transitional stage B cell number J:147129
liver inflammation J:147129
lung inflammation J:147129
Ptprctm1Weis/Ptprctm1Weis
involves: 129X1/SvJ * C57BL/6 		abnormal B cell activation J:66501
abnormal digestion J:66501
abnormal erythropoiesis J:66501
abnormal granulocyte differentiation J:66501
abnormal immune system organ morphology J:66501
abnormal leukocyte cell number J:66501
abnormal T cell activation J:66501
enlarged lymph nodes J:66501
enlarged spleen J:66501
extramedullary hematopoiesis J:66501
glomerulonephritis J:66501
increased anti-double stranded DNA antibody level J:66501
increased B cell number J:66501
increased IgA level J:66501
increased IgG2a level J:66501
increased plasmacytoid dendritic cell number J:66501
increased spleen red pulp amount J:66501
increased spleen white pulp amount J:66501
increased susceptibility to autoimmune disorder J:66501
increased T cell number J:66501
increased urine protein level J:66501
kidney failure J:66501
lymph node hyperplasia J:66501
oliguria J:66501
premature death J:66501
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory