114 phenotypes from 7 alleles in 13 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pthlhtm1a(KOMP)Wtsi/Pthlh+ C57BL/6N-Pthlhtm1a(KOMP)Wtsi/Wtsi	abnormal cranium morphology	J:211773
	abnormal head morphology	J:211773
	increased blood urea nitrogen level	J:211773
Pthlhtm1a(KOMP)Wtsi/Pthlhtm1a(KOMP)Wtsi C57BL/6N-Pthlhtm1a(KOMP)Wtsi/Wtsi	abnormal brain vasculature morphology	J:239583
	abnormal cervical rib	J:239583
	abnormal ductus venosus valve morphology	J:239583
	abnormal forebrain morphology	J:239583
	abnormal inferior vena cava morphology	J:239583
	dilated liver sinusoidal space	J:239583
	embryo tumor	J:239583
	no abnormal phenotype detected	J:239583
	preweaning lethality, complete penetrance	J:211773
Pthlhtm1Ack/Pthlhtm1.1Ack Tmem163Tg(ACTB-cre)2Mrt/0 involves: 129S1/Sv * 129X1/SvJ * BALB/c * FVB/N	abnormal long bone epiphyseal plate morphology	J:69396
	abnormal long bone epiphyseal plate proliferative zone	J:69396
	distended abdomen	J:69396
	domed cranium	J:69396
	neonatal lethality, complete penetrance	J:69396
	premature endochondral bone ossification	J:69396
	protruding tongue	J:69396
	respiratory failure	J:69396
	short mandible	J:69396
	small thoracic cavity	J:69396
Pthlhtm1Ack/Pthlhtm1Ack Tg(Col1a1-cre)1Ack/0 involves: 129S1/Sv * 129X1/SvJ * FVB/N	abnormal bone ossification	J:100918
	abnormal osteoblast morphology	J:100918
	abnormal osteoclast morphology	J:100918
	abnormal trabecular bone morphology	J:100918
	decreased bone mineral density	J:100918
	decreased osteoblast cell number	J:100918
	decreased osteoclast cell number	J:100918
Pthlhtm1Ack/Pthlhtm1Hmk Tg(LGB-cre)74Acl/0 involves: 129 * C57BL/6 * CBA	abnormal bone ossification	J:86536
	abnormal circulating hormone level	J:86536
	abnormal osteoclast morphology	J:86536
	abnormal urine homeostasis	J:86536
	abnormal vitamin D level	J:86536
	increased bone mass	J:86536
	normal reproductive system phenotype	J:86536
Pthlhtm1Ack/Pthlhtm1Hmk Tmem163Tg(ACTB-cre)2Mrt/0 involves: 129 * BALB/c * FVB/N	abnormal long bone epiphyseal plate morphology	J:69396
	abnormal long bone epiphyseal plate proliferative zone	J:69396
	disorganized long bone epiphyseal plate	J:69396
	distended abdomen	J:69396
	domed cranium	J:69396
	neonatal lethality, complete penetrance	J:69396
	premature endochondral bone ossification	J:69396
	protruding tongue	J:69396
	respiratory failure	J:69396
	short mandible	J:69396
	small thoracic cavity	J:69396
Pthlhtm1Broa/Pthlhtm1Broa involves: 129S1/Sv * C57BL/6J * CD-1	abnormal long bone epiphyseal plate proliferative zone	J:128121
	chondrodystrophy	J:128121
	short ribs	J:128121
Pthlhtm1Fbe/Pthlhtm1Fbe involves: 129S1/Sv * 129X1/SvJ	abnormal axial skeleton morphology	J:109505
	abnormal calcium ion homeostasis	J:79622
	abnormal circulating calcium level	J:79622
	abnormal long bone epiphyseal plate morphology	J:109505
	abnormal long bone hypertrophic chondrocyte zone	J:109505
	decreased long bone epiphyseal plate size	J:109505
	domed cranium	J:109505
	neonatal lethality, complete penetrance	J:109505
	short femur	J:109505
	short humerus	J:109505
	short limbs	J:109505
	short radius	J:109505
	short ribs	J:109505
	short ulna	J:109505
Pthlhtm1Fbe/Pthlhtm1Fbe involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal clavicle morphology	J:112521
	abnormal mandible morphology	J:112521
	abnormal osteoblast morphology	J:112521
	abnormal trabecular bone morphology	J:112521
	domed cranium	J:112521
	protruding tongue	J:112521
	short mandible	J:112521
	short snout	J:112521
Pthlhtm1Fbe/Pthlhtm1Fbe involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	failure of tooth eruption	J:109342
Pthlhtm1Hmk/Pthlh+ involves: 129S2/SvPas	abnormal bone ossification	J:100918
	abnormal osteoblast differentiation	J:100918
	abnormal osteoclast morphology	J:100918
	abnormal trabecular bone morphology	J:100918
	decreased osteoblast cell number	J:100918
Pthlhtm1Hmk/Pthlh+ involves: 129S2/SvPas * C57BL/6	decreased long bone epiphyseal plate size	J:99641
Pthlhtm1Hmk/Pthlhtm1Hmk either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)	abnormal axial skeleton morphology	J:16911
	abnormal bone mineralization	J:16911
	abnormal bone trabecula morphology	J:16911
	abnormal cartilage development	J:16911
	abnormal long bone epiphyseal plate morphology	J:16911
	abnormal long bone epiphyseal plate proliferative zone	J:16911
	abnormal long bone metaphysis morphology	J:16911
	abnormal long bone morphology	J:16911
	abnormal rib morphology	J:16911
	abnormal skeleton development	J:16911
	abnormal thoracic cage shape	J:16911
	abnormal vertebral body morphology	J:16911
	chondrodystrophy	J:16911
	cyanosis	J:16911
	decreased length of long bones	J:16911
	domed cranium	J:16911
	increased diameter of long bones	J:16911
	perinatal lethality, complete penetrance	J:16911
	premature endochondral bone ossification	J:16911
	protruding tongue	J:16911
	respiratory failure	J:16911
	short limbs	J:16911
	short mandible	J:16911
	short ribs	J:16911
	short snout	J:16911
	short sternum	J:16911
	splayed ribs	J:16911
Pthlhtm1Hmk/Pthlhtm1Hmk involves: 129S2/SvPas	abnormal bone mineralization	J:50144
	abnormal sternum ossification	J:50144
Pthlhtm1Hmk/Pthlhtm1Hmk involves: 129S2/SvPas * C57BL/6	abnormal long bone morphology	J:77639
	abnormal lung development	J:90274
	abnormal lung interstitium morphology	J:90274
	abnormal lung morphology	J:90274
	abnormal lung saccule morphology	J:90274
	abnormal mesenchymal cell differentiation involved in lung development	J:90274
	abnormal pulmonary alveolus epithelium morphology	J:90274
	abnormal type II pneumocyte morphology	J:90274
	absent type I pneumocytes	J:90274
	atelectasis	J:90274
	decreased alveolar lamellar body number	J:90274
	decreased length of long bones	J:77639
	decreased long bone epiphyseal plate size	J:77639
	decreased surfactant secretion	J:90274
	domed cranium	J:77639
	perinatal lethality, complete penetrance	J:90274
	premature bone ossification	J:77639
	respiratory failure	J:90274
	short mandible	J:77639
	small lung	J:90274
	small lung saccule	J:90274
	small thoracic cavity	J:90274
	thick lung-associated mesenchyme	J:90274
Pthlhtm1Hmk/Pthlhtm1Hmk involves: 129S2/SvPas * C57BL/6J	abnormal bone mineralization	J:76407
	abnormal bone structure	J:76407
	abnormal cartilage development	J:76407
	abnormal long bone epiphyseal plate proliferative zone	J:76407
	abnormal long bone hypertrophic chondrocyte zone	J:76407
	abnormal osteoclast morphology	J:76407
	abnormal trabecular bone morphology	J:76407
	decreased length of long bones	J:76407
	decreased osteoclast cell number	J:76407
	disproportionate dwarf	J:76407
	enlarged parathyroid gland	J:76407
	increased chondrocyte apoptosis	J:76407
	increased compact bone thickness	J:76407
	increased osteoblast apoptosis	J:76407
	increased osteoblast cell number	J:76407
	increased osteocyte apoptosis	J:76407
	increased width of hypertrophic chondrocyte zone	J:76407
	perinatal lethality, complete penetrance	J:76407
	short limbs	J:76407
	short tibia	J:76407
Pthlhtm2Ack/Pthlhtm2Ack involves: 129S2/SvPas * C57BL/6	abnormal autophagy	J:142669
	abnormal blood vessel morphology	J:142669
	abnormal gait	J:142669
	abnormal long bone epiphyseal plate proliferative zone	J:142669
	abnormal trabecular bone morphology	J:142669
	cachexia	J:142669
	decreased body size	J:142669
	decreased bone mineral density	J:142669
	decreased brain size	J:142669
	decreased cell proliferation	J:142669
	decreased chondrocyte number	J:142669
	decreased chondrocyte proliferation	J:142669
	decreased circulating glucose level	J:142669
	decreased long bone epiphyseal plate size	J:142669
	decreased osteoblast cell number	J:142669
	decreased osteoclast cell number	J:142669
	decreased total body fat amount	J:142669
	normal growth/size/body region phenotype	J:142669
	hyperkeratosis	J:142669
	increased apoptosis	J:142669
	kyphosis	J:142669
	osteoporosis	J:142669
	postnatal growth retardation	J:142669
	postnatal lethality, complete penetrance	J:142669
	premature aging	J:142669
	normal skeleton phenotype	J:142669
	thin epidermis	J:142669