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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Ptgs2
prostaglandin-endoperoxide synthase 2
MGI:97798
48 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
ApcMin/Apc+
Ptgs2tm1Unc/Ptgs2tm1Unc
involves: 129P2/OlaHsd * C57BL/6J
decreased prostaglandin level J:64401
decreased tumor incidence J:64401
intestine polyps J:64401
premature death J:64401
Apctm1Mmt/Apc+
Ptgs2tm1Jed/Ptgs2+
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J
abnormal intestine morphology J:36816
colon polyps J:36816
Apctm1Mmt/Apc+
Ptgs2tm1Jed/Ptgs2tm1Jed
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J
abnormal intestine morphology J:36816
Gins4tm1Ntak/Gins4+
Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0
Tg(Krt19-Wnt1)2Maos/0
involves: 129P2/OlaHsd * C3H * C57BL/6
decreased tumor growth/size J:209708
Hmga1tm1Mina/Hmga1tm1Mina
Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0
Tg(Krt19-Wnt1)2Maos/0
involves: C3H * C57BL/6 * CBA
increased stomach tumor incidence J:153058
Hrhr/Hrhr
Ptgs2tm1Unc/Ptgs2+
involves: 129P2/OlaHsd * C57BL/6 * SKH1
decreased incidence of tumors by UV induction J:121635
decreased prostaglandin level J:121635
increased cell proliferation J:121635
Hrhr/Hrhr
Ptgs2tm1Unc/Ptgs2tm1Unc
involves: 129P2/OlaHsd * C57BL/6 * SKH1
premature death J:121635
Hrhr/Hrhr
Tg(KRT14-Ptgs2)1Sumf/0
involves: C57BL/6 * DBA/2 * FVB/N * SKH1
decreased cell proliferation J:121635
increased incidence of tumors by UV-induction J:121635
increased prostaglandin level J:121635
Ptger2tm1Brey/Ptger2tm1Brey
Tg(MMTV-PTGS2)#Thla/0
involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N
normal reproductive system phenotype J:98801
Ptgs1tm1Fun/Ptgs1tm1Fun
Ptgs2tm2.1(Ptgs1)Fun/Ptgs2tm2.1(Ptgs1)Fun
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
prenatal lethality J:118171
Ptgs1tm1Unc/Ptgs1+
Ptgs2tm1Unc/Ptgs2+
involves: 129P2/OlaHsd * C57BL/6J
delayed parturition J:67208
Ptgs1tm1Unc/Ptgs1+
Ptgs2tm1Unc/Ptgs2tm1Unc
involves: 129P2/OlaHsd * C57BL/6J
patent ductus arteriosus J:67208
postnatal lethality, complete penetrance J:67208
Ptgs1tm1Unc/Ptgs1tm1Unc
Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
neonatal lethality, complete penetrance J:109548
patent ductus arteriosus J:109548
Ptgs1tm1Unc/Ptgs1tm1Unc
Ptgs2tm1Unc/Ptgs2+
involves: 129P2/OlaHsd * C57BL/6J
delayed parturition J:67208
Ptgs1tm1Unc/Ptgs1tm1Unc
Ptgs2tm1Unc/Ptgs2tm1Unc
involves: 129P2/OlaHsd * C57BL/6 * CD-1
neonatal lethality, complete penetrance J:64073
patent ductus arteriosus J:64073
Ptgs1tm1Unc/Ptgs1tm1Unc
Ptgs2tm1Unc/Ptgs2tm1Unc
involves: 129P2/OlaHsd * C57BL/6J
cyanosis J:67208
neonatal lethality, incomplete penetrance J:67208
patent ductus arteriosus J:67208
postnatal lethality, complete penetrance J:67208
respiratory distress J:67208
Ptgs2tm1Jed/Ptgs2+
Stk11tm1Tpm/Stk11+
involves: 129S7/SvEvBrd * C57BL/6 * CD-1
gastric polyps J:93361
intestine polyps J:93361
Ptgs2tm1Jed/Ptgs2tm1Jed
Stk11tm1Tpm/Stk11+
involves: 129S7/SvEvBrd * C57BL/6 * CD-1
decreased tumor incidence J:93361
gastric polyps J:93361
intestine polyps J:93361
Ptgs2tm2(Ptgs1)Fun/Ptgs2tm2(Ptgs1)Fun
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal macrophage physiology J:118171
preweaning lethality, incomplete penetrance J:118171
Ptgs2tm2.1(Ptgs1)Fun/Ptgs2tm2.1(Ptgs1)Fun
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB
abnormal fertility/fecundity J:118171
abnormal macrophage physiology J:118171
abnormal renal glomerulus morphology J:118171
decreased litter size J:118171
decreased urine prostaglandin level J:118171
decreased vascular permeability J:118171
increased blood urea nitrogen level J:118171
kidney inflammation J:118171
peritoneal inflammation J:118171
Tg(APP695)3Dbo/0
Tg(Eno2-PTGS2)32Pasi/0
Tg(PSEN1)5Dbo/0
involves: C3H/HeJ * C57BL/6J
amyloid beta deposits J:100961
normal nervous system phenotype J:100961
Tg(Eno2-PTGS2)32Pasi/0
involves: C3H/HeNTac * C57BL/6NTac
abnormal neuron physiology J:100961
increased susceptibility to neuronal excitotoxicity J:100973
normal nervous system phenotype J:100961
premature death J:100973
seizures J:100973
tonic-clonic seizures J:100973
Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0
involves: C3H * C57BL/6
gastric metaplasia J:116782
Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0
Tg(Krt19-Wnt1)2Maos/0
involves: C3H * C57BL/6
abnormal stomach glandular epithelium morphology J:116782
gastric metaplasia J:116782
increased gastric adenocarcinoma incidence J:116782
increased stomach tumor incidence J:116782, J:153058
premature death J:116782
Tg(MMTV-PTGS2)#Thla/0
involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N
abnormal mammary gland development J:98801
mammary gland hyperplasia J:98801
Tg(MMTV-PTGS2)#Thla/0
involves: CD-1
abnormal involution of the mammary gland J:68565
increased adenocarcinoma incidence J:68565
increased mammary adenocarcinoma incidence J:68565
increased mammary gland ductal carcinoma incidence J:68565
mammary gland hyperplasia J:68565

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory