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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Plp1
proteolipid protein (myelin) 1
MGI:97623
49 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Casp12tm1Yuan/Casp12tm1Yuan
Plp1jp-msd/Y
involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10 * BALB/c
increased apoptosis J:121540
premature death J:121540
Casp12tm1Yuan/Casp12tm1Yuan
Plp1jp-rsh/Y
involves: 129S4/SvJae * C3H * C57BL/6 * STOCK Rb(1.3)1Bnr
abnormal locomotor coordination J:121540
increased apoptosis J:121540
Gpm6btm1Kan/Gpm6b+
Plp1tm1Kan/Plp1tm1Kan
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
abnormal motor capabilities/coordination/movement J:193310
premature death J:193310
Gpm6btm1Kan/Gpm6btm1Kan
Plp1tm1Kan/Plp1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
abnormal motor capabilities/coordination/movement J:193310
premature death J:193310
Gpm6btm1KanPlp1tm1Kan/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
abnormal auditory brainstem response waveform shape J:193310
abnormal brain white matter morphology J:193310
abnormal glial cell morphology J:193310
abnormal motor coordination/balance J:193310
abnormal myelin sheath morphology J:193310
abnormal myelination J:193310
abnormal oligodendrocyte apoptosis J:193310
abnormal oligodendrocyte morphology J:193310
abnormal stationary movement J:193310
absent visual evoked potential J:193310
astrocytosis J:193310
ataxia J:193310
axon degeneration J:193310
decreased anterior commissure size J:193310
decreased cholesterol level J:193310
decreased corpus callosum size J:193310
demyelination J:193310
enlarged brain ventricles J:193310
normal hearing/vestibular/ear phenotype J:193310
hunched posture J:193310
impaired hearing J:193310
increased apoptosis J:193310
microgliosis J:193310
muscle hypertonia J:193310
muscle spasm J:193310
neuron degeneration J:193310
premature death J:193310
retinal degeneration J:193310
tremors J:193310
Mbpshi/Mbpshi
Plp1tm1Kan/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SWV
abnormal myelin sheath morphology J:38856
abnormal myelination J:38856
ataxia J:38856
normal mortality/aging J:38856
tremors J:38856
Mbpshi/Mbpshi
Plp1tm1Kan/Y
involves: 129S1/Sv * 129X1/SvJ * SWV
axonal spheroids J:48031
demyelination J:48031
Plp1tm1Kan/Y
Cnptm1(cre)Kan/Cnp+
involves: 129S1/Sv * 129X1/SvJ
abnormal hippocampal fimbria morphology J:245100
astrocytosis J:245100
axonal spheroids J:245100
increased T cell number J:245100
microgliosis J:245100
Plp1tm1Kan/Y
Tspan2tm1Hbw/Tspan2tm1Hbw
B6.Cg-Tspan2tm1Hbw Plp1tm1Kan
astrocytosis J:201143
axon degeneration J:201143
axonal spheroids J:201143
brain inflammation J:201143
decreased body weight J:201143
demyelination J:201143
hindlimb paralysis J:201143
kyphosis J:201143
microgliosis J:201143
Tg(PLP1*)4Rsj/0
involves: CD-1
abnormal brain morphology J:171534
abnormal electroretinogram waveform feature J:171534
abnormal gait J:171534
abnormal motor coordination/balance J:24069
abnormal myelin sheath morphology J:24069
abnormal myelination J:24069, J:161344
astrocytosis J:161344
ataxia J:24069
CNS inflammation J:161344
demyelination J:24069, J:161344, J:171534
environmentally induced seizures J:24069
hindlimb paralysis J:24069
lethargy J:24069
paraparesis J:24069
premature death J:24069, J:171534
tremors J:24069, J:171534
weakness J:24069
Tg(Plp)66Kan/0
Tg(Plp)72Kan/0
involves: C57BL/6 * DBA
astrocytosis J:17373
convulsive seizures J:17373
dysmyelination J:17373
premature death J:17373

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory