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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pkd1
polycystin 1, transient receptor potential channel interacting
MGI:97603
79 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gpsm1tm1.1Lajb/Gpsm1+
Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
involves: 129S6/SvEvTac 		enlarged kidney J:193175
increased blood urea nitrogen level J:193175
polycystic kidney J:193175
Gpsm1tm1.1Lajb/Gpsm1tm1.1Lajb
Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
involves: 129S6/SvEvTac 		abnormal kidney physiology J:193175
enlarged kidney J:193175
increased blood urea nitrogen level J:193175
increased circulating creatinine level J:193175
polycystic kidney J:193175
Hoxb3osem1Kabo/Hoxb3osem1Kabo
Pkd1tm1.1Pcha/Pkd1tm1.1Pcha
involves: 129 * C57BL/6J 		increased kidney cell proliferation J:345935
kidney cyst J:345935
Hoxb3osem1Kabo/Hoxb3osem1Kabo
Pkd1tm2Ggg/Pkd1tm2Ggg
Tg(Pkhd1-cre)1Igr/0
involves: 129S4/SvJae * C57BL/6J 		increased kidney cell proliferation J:345935
kidney cyst J:345935
Mirc1tm1.1Tyj/Mirc1tm1.1Tyj
Pkd1tm1.1Pcha/Pkd1tm1.1Pcha
Tg(Cdh16-cre)91Igr/0
involves: 129 * 129S4/SvJae * C57BL/6 * ICR 		decreased blood urea nitrogen level J:244067
normal renal/urinary system phenotype J:244067
Mirc1tm1.1Tyj/Mirc1tm1.1Tyj
Pkd1tm1.1Pcha/Pkd1tm2Som
Tg(Cdh16-cre)91Igr/0
involves: 129 * 129S4/SvJae * C57BL/6 * ICR 		abnormal peroxisome morphology J:244067
abnormal redox activity J:244067
decreased circulating creatinine level J:244067
decreased kidney cell proliferation J:244067
decreased kidney weight J:244067
increased fatty acid oxidation J:244067
kidney cyst J:244067
normal renal/urinary system phenotype J:244067
Mirc1tm1.1Tyj/Mirc1tm1.1Tyj
Pkd1tm2Som/Pkd1tm2Som
Tg(Cdh16-cre)91Igr/0
involves: 129S4/SvJae * C57BL/6 * ICR 		decreased circulating creatinine level J:244067
decreased kidney cell proliferation J:244067
decreased kidney weight J:244067
premature death J:244067
Nek8jck/Nek8+
Pkd1tm1Bdgz/Pkd1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		kidney cyst J:130086
Pkd1tm1.1Pcha/Pkd1+
Pkd2tm1Som/Pkd2tm2Som
involves: 129 * C57BL/6J * SJL 		increased blood urea nitrogen level J:220561
increased kidney weight J:220561
polycystic kidney J:220561
Pkd1tm1.1Pcha/Pkd1tm1.1Pcha
Pkd2tm1Som/Pkd2+
involves: 129 * C57BL/6J * SJL 		increased blood urea nitrogen level J:220561
increased kidney weight J:220561
polycystic kidney J:220561
Pkd1tm1.1Pcha/Pkd1tm1.1Pcha
Pkd2tm1Som/Pkd2tm2Som
involves: 129 * C57BL/6J * SJL 		increased blood urea nitrogen level J:220561
increased kidney weight J:220561
polycystic kidney J:220561
premature death J:220561
Pkd1tm1.1Pcha/Pkd1tm1.1Pcha
Pkd2tm2Som/Pkd2+
involves: 129 * C57BL/6J * SJL 		increased blood urea nitrogen level J:220561
increased kidney weight J:220561
polycystic kidney J:220561
Pkd1tm1.1Pcha/Pkd1tm1.1Pcha
Pparatm1Gonz/Pparatm1Gonz
involves: 129 * 129S4/SvJae * C57BL/6 		enlarged kidney J:244067
increased kidney cell proliferation J:244067
polycystic kidney J:244067
Pkd1tm1.1Pcha/Pkd1tm1.1Pcha
Tg(Cdh16-cre)91Igr/0
involves: 129 * 129S4/SvJae * C57BL/6 * ICR 		increased blood urea nitrogen level J:244067
polycystic kidney J:244067
renal fibrosis J:244067
Pkd1tm1Ggg/Pkd1+
Pkhd1tm1.1Ggg/Pkhd1tm1.1Ggg
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 		abnormal liver morphology J:125113
dilated kidney collecting duct J:125113
enlarged kidney J:125113
kidney cyst J:125113
liver cyst J:125113
pancreas cyst J:125113
perinatal lethality, incomplete penetrance J:125113
postnatal growth retardation J:125113
premature death J:125113
Pkd1tm1Som/Pkd1+
Pkd2tm2Som/Pkd2+
involves: 129/Sv * C57BL/6 * SJL 		kidney cyst J:78422
liver cyst J:78422
Pkd1tm1Som/Pkd1+
Prkcshtm1Som/Prkcshtm1Som
Tg(Cdh16-cre)91Igr/0
involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL 		abnormal loop of Henle ascending limb thick segment morphology J:188763
dilated kidney collecting duct J:188763
increased blood urea nitrogen level J:188763
increased kidney apoptosis J:188763
increased kidney cell proliferation J:188763
increased kidney weight J:188763
kidney cyst J:188763
Pkd1tm1Som/Pkd1+
Sec63tm1Som/Sec63tm1Som
Tg(Cdh16-cre)91Igr/0
involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL 		abnormal loop of Henle ascending limb thick segment morphology J:188763
dilated kidney collecting duct J:188763
increased blood urea nitrogen level J:188763
increased kidney apoptosis J:188763
increased kidney cell proliferation J:188763
increased kidney weight J:188763
kidney cyst J:188763
Pkd1tm1Som/Pkd1+
Tg(Pkd1*)39Mtru/0
involves: 129/Sv * C57BL/6J * CBA/J * SJL 		dilated renal tubule J:198147
polycystic kidney J:198147
Pkd2tm3Som/Pkd2tm3Som
Tg(Pkd1)248Som/0
Tg(Pkhd1-cre)1Igr/0
involves: C57BL/6J * SJL/J 		kidney cyst J:188763
Prkcshtm1Som/Prkcshtm1Som
Tg(Pkd1)248Som/0
Tg(Cdh16-cre)91Igr/0
involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL/J 		dilated renal tubule J:188763
kidney cyst J:188763
Sec63tm1Som/Sec63tm1Som
Tg(Pkd1)248Som/0
Tg(Cdh16-cre)91Igr/0
involves: 129 * C57BL/6 * C57BL/6J * ICR * SJL/J 		kidney cyst J:188763
Tg(Pkd1)6Mtru/0
involves: C57BL/6J * CBA/J 		abnormal aortic valve cusp morphology J:157952
abnormal renal tubule epithelium morphology J:157952
cardiac hypertrophy J:157952
decreased hematocrit J:157952
decreased urine creatinine level J:157952
decreased urine urea nitrogen level J:157952
dilated heart J:157952
dilated renal tubule J:157952
glomerulosclerosis J:157952
heart left ventricle hypertrophy J:157952
hematuria J:157952
increased blood osmolality J:157952
increased cardiac muscle contractility J:157952
increased circulating sodium level J:157952
increased heart weight J:157952
increased hepatocyte proliferation J:157952
increased kidney cell proliferation J:157952
increased urine osmolality J:157952
increased urine protein level J:157952
kidney cortex cyst J:157952
kidney cyst J:157952
kidney epithelium hyperplasia J:157952
kidney medulla cyst J:157952
liver cyst J:157952
liver fibrosis J:157952
nephrocalcinosis J:157952
nephrolithiasis J:157952
pale kidney J:157952
polyuria J:157952
premature death J:157952
renal cast J:157952
renal interstitial fibrosis J:157952
thick interventricular septum J:157952
thick ventricular wall J:157952
Tg(Pkd1)18Mtru/0
involves: C57BL/6J * CBA/J 		cardiac fibrosis J:157952
decreased hematocrit J:157952
glomerulosclerosis J:157952
hypertension J:157952
increased urine protein level J:157952
kidney cortex cyst J:157952
kidney cyst J:157952
kidney medulla cyst J:157952
nephrocalcinosis J:157952
nephrolithiasis J:157952
pale kidney J:157952
premature death J:157952
Tg(Pkd1)26Mtru/0
involves: C57BL/6J * CBA/J 		abnormal aortic valve cusp morphology J:157952
abnormal cerebellum development J:157952
abnormal myocardium layer morphology J:157952
abnormal renal tubule epithelium morphology J:157952
abnormal sagittal suture morphology J:157952
aneurysm J:157952
aortic valve stenosis J:157952
calcified aortic valve J:157952
cardiac fibrosis J:157952
cardiac hypertrophy J:157952
decreased hematocrit J:157952
decreased urine protein level J:157952
dilated brain ventricle J:157952
dilated heart J:157952
dilated renal tubule J:157952
dystrophic cardiac calcinosis J:157952
glomerulosclerosis J:157952
heart left ventricle hypertrophy J:157952
hematuria J:157952
hydrocephaly J:157952
hypertension J:157952
increased blood osmolality J:157952
increased cardiac output J:157952
increased cardiac stroke volume J:157952
increased circulating phosphate level J:157952
increased circulating sodium level J:157952
increased heart weight J:157952
increased hepatocyte proliferation J:157952
increased kidney cell proliferation J:157952
increased urine protein level J:157952
kidney cortex cyst J:157952
kidney cyst J:157952
kidney epithelium hyperplasia J:157952
kidney medulla cyst J:157952
liver cyst J:157952
liver fibrosis J:157952
nephrocalcinosis J:157952
nephrolithiasis J:157952
pale kidney J:157952
polyuria J:157952
premature death J:157952
renal cast J:157952
renal interstitial fibrosis J:157952
small cerebellum J:157952
subarachnoid hemorrhage J:157952
thick interventricular septum J:157952
thick ventricular wall J:157952
Tg(Pkd1*)39Mtru/0
involves: C57BL/6J * CBA/J 		abnormal ion homeostasis J:198147
abnormal renal glomerulus morphology J:198147
decreased hematocrit J:198147
decreased urine creatinine level J:198147
decreased urine osmolality J:198147
decreased urine urea nitrogen level J:198147
dilated renal tubule J:198147
increased blood urea nitrogen level J:198147
increased circulating creatinine level J:198147
increased urine protein level J:198147
kidney failure J:198147
pale kidney J:198147
polycystic kidney J:198147
polyuria J:198147
premature death J:198147
renal glomerulus cyst J:198147
renal interstitial fibrosis J:198147
renal tubule atrophy J:198147
Tulp3tm1c(EUCOMM)Hmgu/Tulp3+
Pkd1tm2Ggg/Pkd1tm2Ggg
Tg(Pax8-rtTA2S*M2)1Koes/0
Tg(tetO-cre)1Jaw/0
involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA * SJL 		increased blood urea nitrogen level J:284006
increased kidney weight J:284006
polycystic kidney J:284006
Tulp3tm1c(EUCOMM)Hmgu/Tulp3tm1c(EUCOMM)Hmgu
Pkd1tm2Ggg/Pkd1+
Tg(Pax8-rtTA2S*M2)1Koes/0
Tg(tetO-cre)1Jaw/0
involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA * SJL 		dilated renal tubule J:284006
increased blood urea nitrogen level J:284006
increased kidney weight J:284006
polycystic kidney J:284006
Tulp3tm1c(EUCOMM)Hmgu/Tulp3tm1c(EUCOMM)Hmgu
Pkd1tm2Ggg/Pkd1tm2Ggg
Tg(Pax8-rtTA2S*M2)1Koes/0
Tg(tetO-cre)1Jaw/0
involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA * SJL 		increased blood urea nitrogen level J:284006
increased kidney weight J:284006
polycystic kidney J:284006
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory