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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Prkaca
protein kinase, cAMP dependent, catalytic, alpha
MGI:97592
40 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Prkacatm1Gsm/Prkaca+
Prkacbtm1Gsm/Prkacbtm1Gsm
involves: 129X1/SvJ * C57BL/6
abnormal dorsal root ganglion morphology J:76765
abnormal embryonic neuroepithelium morphology J:76765
abnormal neural tube morphology J:76765
abnormal neuron specification J:76765
abnormal spine curvature J:76765
abnormal vertebral arch morphology J:76765
abnormal vertebral column morphology J:76765
disorganized dorsal root ganglion J:76765
increased neural tube apoptosis J:76765
postnatal lethality J:76765
spina bifida J:76765
Prkacatm1Gsm/Prkaca+
Prkar1atm1.1Lsk/Prkar1a+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal bone mineralization J:160299
abnormal compact bone morphology J:160299
abnormal periosteum morphology J:160299
decreased bone mineral density J:160299
increased osteochondroma incidence J:160299
increased osteosarcoma incidence J:160299
increased skeletal tumor incidence J:160299, J:166728
normal neoplasm J:160299
Prkacatm1Gsm/Prkacatm1Gsm
Prkacbtm1Gsm/Prkacb+
involves: 129X1/SvJ * C57BL/6
abnormal dorsal root ganglion morphology J:76765
abnormal embryonic neuroepithelium morphology J:76765
abnormal neural tube morphology J:76765
abnormal neuron specification J:76765
abnormal spine curvature J:76765
abnormal vertebral arch morphology J:76765
abnormal vertebral column morphology J:76765
disorganized dorsal root ganglion J:76765
embryonic lethality, complete penetrance J:76765
exencephaly J:76765
spina bifida J:76765
Prkacatm1Gsm/Prkacatm1Gsm
Prkacbtm1Gsm/Prkacbtm1Gsm
involves: 129X1/SvJ * C57BL/6
embryonic lethality between somite formation and embryo turning, complete penetrance J:76765
Prkacatm1Gsm/Prkacatm1Gsm
Prkar1atm1Gsm/Prkar1atm1Gsm
involves: 129X1/SvJ * C57BL/6
pericardial edema J:78010
Tg(Myh6-Prkaca)2Eno/0
Not Specified
abnormal atrial thrombosis J:263774
abnormal heart echocardiography feature J:263774
anasarca J:263774
atrial fibrillation J:263774
cardiac fibrosis J:263774
cardiac hypertrophy J:263774
congestive heart failure J:263774
decreased cardiac muscle contractility J:263774
decreased heart rate J:263774
dilated cardiomyopathy J:263774
enlarged heart J:263774
enlarged myocardial fiber J:263774
premature death J:263774
sinoatrial block J:263774
thick ventricular wall J:263774
ventricular premature beat J:263774
Tg(Myh6-Prkaca)33Eno/0
Not Specified
abnormal atrial thrombosis J:263774
cardiac fibrosis J:263774
cardiac hypertrophy J:263774
congestive heart failure J:263774
dilated cardiomyopathy J:263774
edema J:263774
enlarged heart J:263774
enlarged myocardial fiber J:263774
premature death J:263774
thick ventricular wall J:263774

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory