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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
MGI:97583
64 phenotypes from 9 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pik3r1m1Btlr/Pik3r1m1Btlr
C57BL/6J-Pik3r1m1Btlr 		decreased B cell number J:254890
decreased B-1a cell number J:254890
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:254890
increased CD8-positive, alpha-beta memory T cell number J:254890
Pik3r1M2Btlr/Pik3r1+
C57BL/6J-Pik3r1M2Btlr 		decreased B-1 B cell number J:254892
decreased B-1a cell number J:254892
decreased B-1b cell number J:254892
decreased B-2 B cell number J:254892
decreased NK T cell number J:254892
increased B-1b cell number J:254892
Pik3r1m3Btlr/Pik3r1m3Btlr
C57BL/6J-Pik3r1m3Btlr 		increased B-1b cell number J:272853
Pik3r1tm1.1Geno/Pik3r1+
involves: C57BL/6 * C57BL/6J 		abnormal epididymal fat pad morphology J:234657
decreased adipocyte glucose uptake J:234657
decreased body length J:234657
decreased body size J:234657
decreased body weight J:234657
decreased insulin secretion J:234657
decreased subcutaneous adipose tissue amount J:234657
decreased white fat cell size J:234657
hyperglycemia J:234657
impaired glucose tolerance J:234657
increased circulating insulin level J:234657
increased circulating insulin-like growth factor I level J:234657
insulin resistance J:234657
lipodystrophy J:234657
pancreatic islet hyperplasia J:234657
Pik3r1tm1.1Geno/Pik3r1tm1.1Geno
involves: C57BL/6 * C57BL/6J 		embryonic lethality, complete penetrance J:234657
Pik3r1tm1Dfr/Pik3r1tm1Dfr
involves: 129S6/SvEvTac 		abnormal B cell differentiation J:104166
decreased immature B cell number J:104166
decreased mature B cell number J:104166
decreased pre-B cell number J:104166
increased pro-B cell number J:104166
Pik3r1tm1Dfr/Pik3r1tm1Dfr
involves: 129S6/SvEvTac * C57BL/6 		abnormal brown adipose tissue morphology J:65523
abnormal glucose homeostasis J:65523
arrested B cell differentiation J:52229
chylous ascites J:65523
decreased B cell proliferation J:52229
decreased circulating insulin level J:65523
decreased mature B cell number J:52229
dystrophic cardiac calcinosis J:65523
hepatic necrosis J:65523
hypoglycemia J:65523
improved glucose tolerance J:65523
increased skeletal muscle fiber size J:65523
postnatal lethality, incomplete penetrance J:52229
Pik3r1tm1Khn/Pik3r1tm1Khn
involves: 129S4/SvJae * C57BL/6J 		abnormal fat cell morphology J:87598
abnormal fat pad morphology J:87598
abnormal glucose homeostasis J:87598
abnormal lipid homeostasis J:87598
decreased circulating insulin level J:87598
decreased triglyceride level J:87598
normal growth/size/body region phenotype J:87598
increased insulin sensitivity J:87598
Pik3r1tm1Lca/Pik3r1tm1Lca
Tg(Ckmm-cre)5Khn/0
involves: 129S6/SvEvTac * C57BL/6 * FVB 		no abnormal phenotype detected J:102176
Pik3r1tm1Lca/Pik3r1tm1Lca
Tg(OPN1LW-cre)4Yzl/0
involves: 129S6/SvEvTac * FVB/N 		abnormal retina cone cell morphology J:232389
abnormal ribbon synapse morphology J:232389
abnormal synapse morphology J:232389
decreased b-wave amplitude J:232389
retina cone cell degeneration J:232389
Pik3r1tm1Tka/Pik3r1tm1Tka
involves: C57BL/6 * CBA 		abnormal B cell physiology J:113491
abnormal humoral immune response J:52228
decreased B cell number J:52228
decreased B cell proliferation J:52228, J:113491
decreased circulating glucose level J:52576
decreased circulating insulin level J:52576
decreased mature B cell number J:52228
decreased pre-B cell number J:52228
decreased pro-B cell number J:52228
hypoglycemia J:52576
increased adipocyte glucose uptake J:52576
increased insulin sensitivity J:52576
increased muscle cell glucose uptake J:52576
increased susceptibility to bacterial infection J:52228
premature death J:52228
Pik3r1tm2Dfr/Pik3r1+
involves: 129S6/SvEvTac * BALB/c * C57BL/6 		hypoglycemia J:94077
improved glucose tolerance J:94077
increased insulin sensitivity J:94077
Pik3r1tm2Dfr/Pik3r1tm2Dfr
either: C.129S6-Pik3r1tm2Dfr or (involves: 129S6/SvEvTac * BALB/c * C57BL/6) 		abnormal B cell differentiation J:94077
abnormal erythropoiesis J:94077
chylous ascites J:94077
hepatic necrosis J:94077
hypoglycemia J:94077
increased skeletal muscle fiber size J:94077
perinatal lethality, complete penetrance J:94077
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/09/2024
MGI 6.23 		The Jackson Laboratory