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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Abcb4
ATP-binding cassette, sub-family B member 4
MGI:97569
82 phenotypes from 2 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Abcb4em1(IMPC)H/Abcb4em1(IMPC)H
C57BL/6NTac-Abcb4em1(IMPC)H/H 		decreased circulating glucose level J:211773
decreased circulating HDL cholesterol level J:211773
decreased hemoglobin content J:211773
decreased mean corpuscular hemoglobin J:211773
decreased mean corpuscular hemoglobin concentration J:211773
decreased mean corpuscular volume J:211773
increased basophil cell number J:211773
increased circulating alanine transaminase level J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating amylase level J:211773
increased circulating aspartate transaminase level J:211773
increased circulating bilirubin level J:211773
increased circulating creatinine level J:211773
increased circulating potassium level J:211773
increased leukocyte cell number J:211773
increased lymphocyte cell number J:211773
increased monocyte cell number J:211773
increased neutrophil cell number J:211773
increased red blood cell distribution width J:211773
increased spleen weight J:211773
thrombocytosis J:211773
Abcb4tm1Bor/Abcb4tm1Bor
C.129P2-Abcb4tm1Bor 		abnormal bone remodeling J:199949
abnormal compact bone morphology J:199949
abnormal enzyme/coenzyme activity J:199949
abnormal trabecular bone morphology J:199949
abnormal trabecular bone volume J:199949
decreased bone mineral content J:199949
decreased bone mineral density J:199949
decreased bone mineral density of femur J:199949
decreased bone trabecula number J:199949
decreased bone volume J:199949
decreased circulating calcium level J:199949
decreased trabecular bone connectivity density J:199949
decreased vitamin D level J:199949
increased alkaline phosphatase activity J:199949
increased circulating phosphate level J:199949
increased transforming growth factor beta level J:199949
increased tumor necrosis factor (ligand) superfamily member 11 level J:199949
liver fibrosis J:199949
Abcb4tm1Bor/Abcb4tm1Bor
CAnNCrl.12P2(FVB)-Abcb4tm1Bor 		enlarged spleen J:217802
increased circulating alanine transaminase level J:217802
increased circulating alkaline phosphatase level J:217802
increased circulating aspartate transaminase level J:217802
increased circulating bilirubin level J:217802
increased hepatocellular carcinoma incidence J:217802
liver cirrhosis J:217802
liver fibrosis J:217802
portal hypertension J:217802
weight loss J:217802
Abcb4tm1Bor/Abcb4tm1Bor
either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * FVB/N) 		abnormal bile canaliculus morphology J:15531, J:21232
abnormal bile composition J:15531
abnormal bile duct morphology J:15531
abnormal bile secretion J:15531
abnormal blood homeostasis J:15531
abnormal circulating alanine transaminase level J:15531
abnormal circulating alkaline phosphatase level J:15531
abnormal circulating aspartate transaminase level J:15531
abnormal circulating bilirubin level J:15531
abnormal hepatobiliary system morphology J:21232
abnormal hepatobiliary system physiology J:21232
abnormal hepatocyte morphology J:15531
abnormal portal triad morphology J:21232
bile duct inflammation J:15531, J:21232
bile duct proliferation J:21232
biliary cirrhosis J:21232
cholestasis J:21232
dilated bile duct J:15531
enlarged liver J:21232
hepatic necrosis J:21232
increased hepatocellular carcinoma incidence J:21232
intrahepatic cholestasis J:15531
liver hemorrhage J:21232
liver inflammation J:15531
reduced female fertility J:21232
Abcb4tm1Bor/Abcb4tm1Bor
FVB.129P2-Abcb4tm1Bor/J 		abnormal bile composition J:100491, J:105357
abnormal bile duct morphology J:105357
abnormal circulating enzyme level J:105357
abnormal feces composition J:100491
abnormal gallbladder size J:105357
abnormal liver morphology J:105357
bile duct inflammation J:105357
dilated bile duct J:105357
enlarged liver J:105357
enlarged spleen J:217802
gallstones J:105357
normal homeostasis/metabolism phenotype J:100491
increased circulating alanine transaminase level J:100491, J:217802
increased circulating alkaline phosphatase level J:105357, J:217802
increased circulating aspartate transaminase level J:100491, J:217802
increased circulating bilirubin level J:105357, J:217802
increased hepatocellular carcinoma incidence J:217802
intrahepatic cholestasis J:105357
liver cirrhosis J:217802
liver fibrosis J:217802
portal hypertension J:217802
Abcb4tm1Bor/Abcb4tm1Bor
involves: 129P2/OlaHsd * BALB/c 		bile duct inflammation J:168123
decreased systemic arterial systolic blood pressure J:168123
liver fibrosis J:168123
Abcb4tm1Bor/Abcb4tm1Bor
involves: 129P2/OlaHsd * FVB/N 		abnormal circulating enzyme level J:114411
abnormal feces composition J:175015
abnormal hepatocyte morphology J:175015
abnormal intestine physiology J:175015
abnormal lipid homeostasis J:114411
abnormal sodium ion homeostasis J:175015
bile duct inflammation J:175015
decreased circulating cholesterol level J:114411
decreased intestinal cholesterol absorption J:114411
focal hepatic necrosis J:175015
increased bile salt level J:175015
increased circulating alanine transaminase level J:114411, J:175015
increased circulating aspartate transaminase level J:114411
increased circulating bilirubin level J:114411
intrahepatic cholestasis J:175015
liver inflammation J:175015
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/09/2024
MGI 6.23 		The Jackson Laboratory