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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Furin
furin (paired basic amino acid cleaving enzyme)
MGI:97513
31 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Furintm1.1Jwmc/Furintm1.1Jwmc
involves: 129P2/OlaHsd * BALB/c * C57BL/6J
embryonic lethality during organogenesis, complete penetrance J:118515
Furintm1Ajmr/Furintm1Ajmr
involves: 129P2/OlaHsd * C57BL/6
abnormal allantois morphology J:50582
abnormal cardinal vein morphology J:50582
abnormal developmental patterning J:50582
abnormal dorsal-ventral axis patterning J:50582
abnormal extraembryonic tissue morphology J:50582
abnormal heart development J:50582
abnormal heart tube morphology J:50582
abnormal neural plate morphology J:50582
abnormal somite shape J:50582
abnormal ventral body wall morphology J:50582
abnormal visceral yolk sac blood island morphology J:50582
absent midgut J:50582
absent vitelline blood vessels J:50582
cardia bifida J:50582
decreased embryo size J:50582
decreased somite size J:50582
embryonic lethality during organogenesis, complete penetrance J:50582
excessive folding of visceral yolk sac J:50582
exencephaly J:50582
failure of chorioallantoic fusion J:50582
failure of heart looping J:50582
failure of initiation of embryo turning J:50582
kinked neural tube J:50582
short rostral-caudal axis J:50582
Furintm1b(EUCOMM)Wtsi/Furin+
C57BL/6N-Furintm1b(EUCOMM)Wtsi/Cnrm
abnormal vibrissa morphology J:211773
brachydactyly J:211773
Furintm1b(EUCOMM)Wtsi/Furintm1b(EUCOMM)Wtsi
C57BL/6N-Furintm1b(EUCOMM)Wtsi/Cnrm
embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Furintm1Jwmc/Furintm1.1Jwmc
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C57BL/6J * CBA
normal liver/biliary system phenotype J:118515
Furintm1Jwmc/Furintm1Jwmc
involves: 129P2/OlaHsd * C57BL/6J
no abnormal phenotype detected J:118515
Furintm1Jwmc/Furintm1Jwmc
Tg(Cd4-cre)1Cwi/0
involves: 129P2/OlaHsd * C57BL/6 * SJL
abnormal regulatory T cell physiology J:204761

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory