Pck1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pck1
phosphoenolpyruvate carboxykinase 1, cytosolic
MGI:97501

41 phenotypes from 5 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pck1^tm1.1Lre/Pck1^tm1.1Lre involves: 129P2/OlaHsd * BALB/c * C57BL/6	abnormal brown fat cell morphology	J:73977
	abnormal white adipose tissue physiology	J:73977
	abnormal white fat cell morphology	J:73977
	decreased abdominal adipose tissue amount	J:73977
	decreased brown fat cell number	J:73977
	decreased brown fat cell size	J:73977
	decreased circulating ketone body level	J:73977
	decreased circulating triglyceride level	J:73977
	decreased epididymal fat pad weight	J:73977
	decreased liver triglyceride level	J:73977
	decreased white adipose tissue amount	J:73977
	decreased white fat cell lipid droplet size	J:73977
	decreased white fat cell size	J:73977
	normal homeostasis/metabolism phenotype	J:73977
	hyperglycemia	J:73977
	lipodystrophy	J:73977
Pck1^tm1.1Mgn/Pck1^tm1.1Mgn involves: 129S6/SvEvTac	no abnormal phenotype detected	J:63929
Pck1^tm1.1Mgn/Pck1^tm1.1Mgn Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S6/SvEvTac	decreased liver glycogen level	J:63929
	enlarged liver	J:63929
	increased circulating free fatty acids level	J:63929
	increased circulating triglyceride level	J:63929
	increased liver triglyceride level	J:63929
	increased liver weight	J:63929
	pale liver	J:63929
Pck1^tm1.2Mgn/Pck1^tm1.2Mgn involves: 129S6/SvEvTac	absent gastric milk in neonates	J:63929
	decreased body size	J:63929
	decreased liver glycogen level	J:63929
	hypoglycemia	J:63929
	lethargy	J:63929
	pale liver	J:63929
	pallor	J:63929
	postnatal lethality, complete penetrance	J:63929
Pck1^tm1Mgn/Pck1^tm1.2Mgn involves: 129S6/SvEvTac	enlarged liver	J:63929
Pck1^tm1Mgn/Pck1^tm1.2Mgn involves: 129S6/SvEvTac	pale liver	J:63929
Pck1^tm1Mgn/Pck1^tm1Mgn involves: 129S6/SvEvTac	enlarged liver	J:63929
Pck1^tm1Rwh/Pck1^tm1Rwh involves: 129P2/OlaHsd * C57BL/6	abnormal circulating amino acid level	J:145210
	abnormal circulating lipid level	J:145210
	abnormal liver morphology	J:145210
	abnormal postnatal growth	J:145210
	decreased circulating glucose level	J:145210
	decreased liver glycogen level	J:145210
	decreased percent body fat/body weight	J:145210
	hepatic steatosis	J:145210
	increased blood urea nitrogen level	J:145210
	increased circulating ammonia level	J:145210
	increased circulating ketone body level	J:145210
	increased circulating lactate level	J:145210
	increased circulating triglyceride level	J:145210
	postnatal lethality, complete penetrance	J:145210

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23