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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Pbx1
pre B cell leukemia homeobox 1
MGI:97495
43 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Cd3etm1Mal/Cd3etm1Mal
Tg(Tcrb-TCF3/PBX1)23Gusa/0
involves: C3H * C57BL/6 * C57BL/6J
increased acute lymphoblastic leukemia incidence J:95693
increased leukemia incidence J:95693
Cdkn2btm1Bbd/Cdkn2btm1Bbd
Pbx1tm1Koss/Pbx1tm1Koss
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129P2/OlaHsd * 129S1/Sv
abnormal spleen mesenchyme morphology J:184521
abnormal spleen morphology J:184521
Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+
Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
Tg(Tcfap2a-cre)1Will/0
involves: 129P2/OlaHsd * 129S/Sv * 129X1/SvJ
normal craniofacial phenotype J:178316
Pax5tm3Mbu/Pax5+
Tcf3tm1(PBX1)Mlc/Tcf3+
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * C57BL/6
abnormal pro-B cell morphology J:226241
arrested B cell differentiation J:226241
decreased immature B cell number J:226241
increased B cell acute lymphoblastic leukemia incidence J:226241
Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd * 129S/Sv
abnormal maxillary shelf morphology J:178316
abnormal nasal capsule morphology J:178316
absent premaxilla J:178316
cleft palate J:178316
cleft upper lip J:178316
neonatal lethality, complete penetrance J:178316
Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
H2az2Tg(Wnt1-cre)11Rth/0
involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA/J
cleft palate J:178316
normal nervous system phenotype J:178316
postnatal lethality, complete penetrance J:178316
Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129P2/OlaHsd * 129S/Sv * 129S1/Sv
abnormal spleen morphology J:184521
spleen hypoplasia J:184521
Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
Tg(Tcfap2a-cre)1Will/0
involves: 129P2/OlaHsd * 129S/Sv
cleft palate J:178316
cleft upper lip J:178316
Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2tm1Mlc
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd * 129S/Sv
cleft upper lip J:178316
decreased apoptosis J:178316
Pbx1tm1Koss/Pbx1tm1Koss
Pbx3tm1Mlc/Pbx3+
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd
cleft palate J:178316
cleft upper lip J:178316
Pbx1tm1Koss/Pbx1tm1Koss
Pbx3tm1Mlc/Pbx3+
Tg(Tcfap2a-cre)1Will/0
involves: 129P2/OlaHsd
cleft palate J:178316
cleft upper lip J:178316
Pbx1tm1Mlc/Pbx1+
Pbx2tm1Mlc/Pbx2+
Pbx3tm1Mlc/Pbx3+
involves: 129S6/SvEvTac
cleft palate J:178316
neonatal lethality, complete penetrance J:178316
Pbx1tm1Mlc/Pbx1+
Wnt9btm1Amc/Wnt9btm1Amc
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd * 129S6/SvEvTac * 129X1/SvJ
cleft palate J:178316
cleft upper lip J:178316
Pbx1tm1Mlc/Pbx1tm1Mlc
Pbx2tm1Mlc/Pbx2+
involves: 129S6/SvEvTac
abnormal lateral nasal prominence morphology J:178316
abnormal maxillary prominence morphology J:178316
abnormal medial nasal prominence morphology J:178316
cleft palate J:178316
cleft upper lip J:178316
edema J:178316
micrognathia J:178316
small snout J:178316
tongue hypoplasia J:178316
Pbx1tm1Mlc/Pbx1tm1Mlc
Pbx3tm1Mlc/Pbx3+
involves: 129S6/SvEvTac
cleft palate J:178316
cleft upper lip J:178316
edema J:178316
micrognathia J:178316
small snout J:178316
tongue hypoplasia J:178316
Pdx1tm1Cvw/Pdx1+
Pbx1tm1Mlc/Pbx1+
involves: 129S6/SvEvTac * C57BL/6
decreased insulin secretion J:75811
disorganized pancreatic islets J:75811
hyperglycemia J:75811
impaired glucose tolerance J:75811
increased insulin sensitivity J:75811
increased urine glucose level J:75811
weight loss J:75811
Tcf3tm1(PBX1)Mlc/Tcf3+
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * C57BL/6
abnormal B cell physiology J:226241
abnormal pro-B cell differentiation J:226241
abnormal pro-B cell morphology J:226241
anemia J:226241
arrested B cell differentiation J:226241
decreased B cell number J:226241
decreased immature B cell number J:226241
enlarged liver J:226241
enlarged lymph nodes J:226241
enlarged spleen J:226241
increased B cell acute lymphoblastic leukemia incidence J:226241
increased leukocyte cell number J:226241
thrombocytopenia J:226241
Tcf3tm1(PBX1)Mlc/Tcf3+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * C57BL/6J * CBA/J
anemia J:226241
arrested B cell differentiation J:226241
decreased B cell number J:226241
decreased immature B cell number J:226241
enlarged liver J:226241
enlarged lymph nodes J:226241
enlarged spleen J:226241
increased B cell acute lymphoblastic leukemia incidence J:226241
increased leukocyte cell number J:226241
thrombocytopenia J:226241
Tcf3tm1(PBX1)Mlc/Tcf3+
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c * C57BL/6
anemia J:226241
arrested B cell differentiation J:226241
decreased B cell number J:226241
decreased immature B cell number J:226241
enlarged liver J:226241
enlarged lymph nodes J:226241
enlarged spleen J:226241
increased B cell acute lymphoblastic leukemia incidence J:226241
increased leukocyte cell number J:226241
thrombocytopenia J:226241
Tg(Tcrb-TCF3/PBX1)19Gusa/0
involves: C3H * C57BL/6 * C57BL/6J
decreased thymocyte number J:95693
increased acute lymphoblastic leukemia incidence J:95693
increased leukemia incidence J:95693
Tg(Tcrb-TCF3/PBX1)23Gusa/0
involves: C3H * C57BL/6 * C57BL/6J
decreased thymocyte number J:95693
increased acute lymphoblastic leukemia incidence J:95693
increased leukemia incidence J:95693

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory