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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Nos2
nitric oxide synthase 2, inducible
MGI:97361
123 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Adh5tm1Stam/Adh5tm1Stam
Nos2tm1Lau/Nos2tm1Lau
involves: 129 * 129P2/OlaHsd
normal mortality/aging J:173666
Agertm1.1Hyam/Ager+
Tg(Ins2-Nos2)40Okam/0
involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2
abnormal renal glomerulus morphology J:116040
glomerulosclerosis J:116040
hyperglycemia J:116040
Agertm1.1Hyam/Agertm1.1Hyam
Tg(Ins2-Nos2)40Okam/0
involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2
abnormal kidney size J:116040
abnormal renal glomerulus morphology J:116040
albuminuria J:116040
decreased circulating creatinine level J:116040
glomerulosclerosis J:116040
hyperglycemia J:116040
ApcMin/Apc+
Nos2tm1Lau/Nos2+
B6.Cg-Nos2tm1Lau ApcMin
decreased tumor growth/size J:73152
decreased tumor incidence J:73152
ApcMin/Apc+
Nos2tm1Lau/Nos2tm1Lau
B6.Cg-Nos2tm1Lau ApcMin
decreased tumor growth/size J:73152
decreased tumor incidence J:73152
ApcMin/Apc+
Msh2tm1Mak/Msh2+
Nos2tm1Mrl/Nos2tm1Mrl
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
intestine polyps J:200824
ApcMin/Apc+
Msh2tm1Mak/Msh2tm1Mak
Nos2tm1Mrl/Nos2tm1Mrl
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
intestine polyps J:200824
Apoetm1Unc/Apoetm1Unc
Nos2tm1Mrl/Nos2tm1Mrl
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
atherosclerotic lesions J:64566
decreased cholesterol level J:64566
normal homeostasis/metabolism phenotype J:64566
increased body weight J:64566
Faslpr/Faslpr
Nos2tm1Mrl/Nos2tm1Mrl
involves: 129S7/SvEvBrd * MRL
abnormal blood homeostasis J:42666
abnormal immunoglobulin level J:42666
abnormal urine homeostasis J:42666
decreased IgG level J:42666
decreased IgM level J:42666
decreased urine nitrite level J:42666
normal immune system phenotype J:42666
Il10tm1Cgn/Il10tm1Cgn
Nos2tm1Lau/Nos2tm1Lau
involves: 129P2/OlaHsd * C57BL/6
increased myocardial infarction size J:70292
Nos1tm1Plh/Nos1tm1Plh
Nos2tm1Lau/Nos2tm1Lau
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J
prenatal lethality, incomplete penetrance J:83112
Nos1tm1Plh/Nos1tm1Plh
Nos2tm1Mrl/Nos2tm1Mrl
involves: 129S4/SvJae * 129S7/SvEvBrd
decreased survivor rate J:100308
decreased urine osmolality J:100308
decreased urine sodium level J:100308
increased blood osmolality J:100308
increased blood urea nitrogen level J:100308
polydipsia J:100308
polyuria J:100308
premature death J:100308
reduced fertility J:100308
Nos1tm1Plh/Nos1tm1Plh
Nos2tm1Mrl/Nos2tm1Mrl
Nos3tm1Plh/Nos3tm1Plh
involves: 129S4/SvJae * 129S7/SvEvBrd
abnormal bone mineralization J:150159
abnormal bone structure J:150159
abnormal coronary artery morphology J:100308
abnormal kidney physiology J:100308
abnormal nitric oxide homeostasis J:100308
abnormal osteoclast physiology J:150159
abnormal renal glomerulus morphology J:100308
abnormal skeleton physiology J:150159
abnormal trabecular bone morphology J:150159
congestive heart failure J:100308
decreased heart rate J:100308
decreased survivor rate J:100308
decreased urine osmolality J:100308
decreased urine sodium level J:100308
dehydration J:100308
enlarged stomach J:100308
glomerular capillary thrombosis J:100308
glomerulosclerosis J:100308
hypertension J:100308
increased blood osmolality J:100308
increased blood urea nitrogen level J:100308
increased bone mineral density J:150159
increased circulating alkaline phosphatase level J:150159
increased circulating creatinine level J:100308
increased osteoclast cell number J:150159
increased prostaglandin level J:100308
increased renal tubule apoptosis J:100308
increased systemic arterial blood pressure J:100308
increased systemic arterial systolic blood pressure J:100308
liver vascular congestion J:100308
polydipsia J:100308
polyuria J:100308
premature death J:100308
pulmonary vascular congestion J:100308
pyloric sphincter hypertrophy J:100308
reduced fertility J:100308
renal tubular necrosis J:100308
visceral vascular congestion J:100308
Nos1tm1Plh/Nos1tm1Plh
Nos2tm1Mrl/Nos2tm1Mrl
Nos3tm1Plh/Nos3tm1Plh
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
abnormal cardiovascular system morphology J:155090
abnormal cardiovascular system physiology J:155090
abnormal circulating glucose level J:155090
abnormal vascular endothelial cell physiology J:155090
abnormal vascular wound healing J:155090
arteriosclerosis J:155090
decreased adiponectin level J:155090
hypertension J:155090
increased circulating LDL cholesterol level J:155090
increased circulating triglyceride level J:155090
increased white adipose tissue amount J:155090
perivascular fibrosis J:155090
premature death J:155090
thick ventricular wall J:155090
Nos2tm1Lau/Nos2tm1Lau
Nos3tm1Unc/Nos3tm1Unc
B6.129P2-Nos3tm1Unc Nos2tm1Lau
prenatal lethality, incomplete penetrance J:83112
Nos2tm1Lau/Nos2tm1Lau
Tg(APPSWE)2576Kha/0
involves: 129P2/OlaHsd * C57BL/6 * SJL
abnormal hippocampus CA3 region morphology J:143551
abnormal long term spatial reference memory J:143551
abnormal subiculum morphology J:143551
amyloid beta deposits J:112919, J:143551
decreased neuron number J:143551
loss of hippocampal neurons J:143551
neuron degeneration J:112919
Nos2tm1Lau/Nos2tm1Lau
Tg(MMTV-PyVT)634Mul/0
B6.Cg-Nos2tm1Lau Tg(MMTV-PyVT)634Mul
abnormal tumor morphology J:121391
decreased tumor incidence J:121391
increased tumor latency J:84218, J:121391
Nos2tm1Lau/Nos2tm1Lau
Tg(MMTV-PyVT)634Mul/0
FVB.Cg-Nos2tm1Lau Tg(MMTV-PyVT)634Mul
decreased tumor latency J:121391
increased tumor growth/size J:121391
increased tumor incidence J:121391
Nos2tm1Lau/Nos2tm1Lau
Tg(RHO-VEGFA)V-6Camp/0
involves: 129P2/OlaHsd * C57BL/6J
abnormal angiogenesis J:106207
Nos2tm1Lau/Nos2tm1Lau
Tg(Thy1-APPSwDutIowa)BWevn/?
involves: C57BL/6
abnormal brain interneuron morphology J:143551
abnormal hippocampus CA3 region morphology J:132221, J:143551
abnormal spatial reference memory J:132221
amyloid beta deposits J:132221, J:143551
decreased neuron number J:143551
decreased subiculum size J:132221, J:143551
hippocampal neuron degeneration J:132221
increased neuron apoptosis J:132221
neurodegeneration J:132221
tau protein deposits J:132221
Nos2tm1Mrl/Nos2tm1Mrl
Nos3tm1Plh/Nos3tm1Plh
involves: 129S4/SvJae * 129S7/SvEvBrd
decreased heart rate J:100308
decreased survivor rate J:100308
decreased urine osmolality J:100308
decreased urine sodium level J:100308
increased blood osmolality J:100308
increased blood urea nitrogen level J:100308
increased systemic arterial systolic blood pressure J:100308
polydipsia J:100308
polyuria J:100308
premature death J:100308
reduced fertility J:100308
Nos2tm1Mrl/Nos2tm1Mrl
Tg(Myh6-Tnf)1.6Amf/?
involves: 129S7/SvEvBrd * C57BL/6 * FVB
abnormal atrioventricular node conduction J:109732
abnormal cardiac muscle contractility J:109732
abnormal heart electrocardiography waveform feature J:109732
abnormal heart ventricle pressure J:109732
abnormal myocardial fiber physiology J:109732
decreased cardiac muscle contractility J:109732
decreased heart rate J:109732
irregular heartbeat J:109732
Tg(Ins2-Nos2)40Okam/0
Tg(Kdr-AGER)102Hyam/0
involves: C57BL/6J * CBA/J * CD-1 * DBA/2
abnormal nephron morphology J:70495
albuminuria J:70495
arteriosclerosis J:70495
atherosclerotic lesions J:70495
expanded mesangial matrix J:70495
glomerulosclerosis J:70495
hyperglycemia J:70495
increased circulating creatinine level J:70495
increased kidney cell proliferation J:70495
increased kidney weight J:70495
renal glomerulus hypertrophy J:70495
Tg(Myh6-tTA)6Smbf/0
Tg(tetO-NOS2,-lacZ)240iMhus/0
involves: C57BL/6 * CBA
abnormal atrioventricular node morphology J:132082
abnormal cardiovascular system physiology J:132082
abnormal heart left ventricle morphology J:132082
abnormal P wave J:132082
absent heartbeat J:132082
atrioventricular block J:132082
cardiac interstitial fibrosis J:132082
cardiac muscle necrosis J:132082
congestive heart failure J:132082
dilated heart ventricle J:132082
edema J:132082
enlarged heart J:132082
heart block J:132082
heart inflammation J:132082
increased body weight J:132082
increased heart ventricle size J:132082
increased heart weight J:132082
lethargy J:132082
premature death J:132082
prolonged P wave J:132082
prolonged PR interval J:132082
respiratory distress J:132082
ventricular tachycardia J:132082
Tg(tetO-NOS2,-lacZ)240iMhus/Tg(tetO-NOS2,-lacZ)240iMhus
C57BL/6-Tg(tetO-NOS2,-lacZ)240iMhus
no abnormal phenotype detected J:132082

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory