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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Nkx3-1
NK3 homeobox 1
MGI:97352
19 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Braftm1Mmcm/Braftm1Mmcm
Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+
Ptentm1Hwu/Pten+
involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
increased metastatic potential J:191327
increased prostate gland adenocarcinoma incidence J:191327
increased prostate gland tumor incidence J:191327
increased prostate intraepithelial neoplasia incidence J:191327
premature death J:191327
Cdkn1btm1Mlf/Cdkn1btm1Mlf
Nkx3-1tm1.1Saa/Nkx3-1tm1.1Saa
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
increased prostate intraepithelial neoplasia incidence J:89571
preneoplasia J:89571
Klf6tm1Fjs/Klf6tm1Fjs
Nkx3-1tm3(cre)Mms/Nkx3-1+
involves: 129/Sv * C57BL/6
abnormal prostate gland anterior lobe morphology J:153183
abnormal prostate gland branching morphogenesis J:153183
abnormal prostate gland duct morphology J:153183
Nkx3-1tm1Mms/Nkx3-1+
Ptentm1Rps/Pten+
involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J
increased prostate gland tumor incidence J:75085
increased prostate intraepithelial neoplasia incidence J:75085
Nkx3-1tm1Mms/Nkx3-1tm1Mms
Ptentm1Rps/Pten+
involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J
increased prostate gland tumor incidence J:75085
increased prostate intraepithelial neoplasia incidence J:75085
Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+
Ptentm1Hwu/Ptentm1Hwu
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
increased prostate gland adenocarcinoma incidence J:153425
increased prostate intraepithelial neoplasia incidence J:153425, J:191327
Nkx3-2tm1Bobh/Nkx3-2tm1Bobh
Nkx3-1tm1Hha/Nkx3-1tm1Hha
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
abnormal axial skeleton morphology J:79198
abnormal cartilage development J:79198
abnormal cervical atlas morphology J:79198
abnormal lumbar vertebrae morphology J:79198
abnormal rib morphology J:79198
abnormal sclerotome morphology J:79198
abnormal vertebrae development J:79198
abnormal vertebral body morphology J:79198
kinked tail J:79198
lethality throughout fetal growth and development, complete penetrance J:79198

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory