Adam17tm1.1Wesh/Adam17tm1.1Wesh
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
|
abnormal myocardial trabeculae morphology |
J:210193
|
|
abnormal myocardium layer morphology |
J:210193
|
|
enlarged heart |
J:210193
|
|
normal
mortality/aging |
J:210193
|
|
thin myocardium |
J:210193
|
Akap6tm1.1Mskf/Akap6tm1.1Mskf
Nkx2-5tm1(cre)Rjs/0
involves: 129S7/SvEvBrd * C57BL/6 * SJL
|
no abnormal phenotype detected |
J:214288
|
Atoh8tm1.1Mlkn/Atoh8tm1.1Mlkn
Gata4tm1.1Sad/Gata4+
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129 * C57BL/6
|
normal
mortality/aging |
J:203454
|
Bmp2tm1Jfm/Bmp2tm1Jfm
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S4/SvJaeSor
|
abnormal cardiac epithelial to mesenchymal transition |
J:104417
|
|
abnormal cardiac jelly morphology |
J:104417
|
|
abnormal fetal atrioventricular canal morphology |
J:104417
|
|
abnormal myocardium layer morphology |
J:104417
|
|
embryonic growth retardation |
J:104417
|
|
embryonic lethality during organogenesis, complete penetrance |
J:104417
|
|
pericardial effusion |
J:104417
|
Bmp2tm1Vrs/Bmp2tm1Vrs
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129S1/Sv * C57BL/6
|
abnormal heart development |
J:110615
|
|
absent atrioventricular cushions |
J:110615
|
|
cardiac edema |
J:110615
|
|
decreased embryo size |
J:110615
|
|
embryonic lethality during organogenesis, complete penetrance |
J:110615
|
|
pericardial effusion |
J:110615
|
Bmp4tm1Jfm/Bmp4tm1.1Jfm
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S4/SvJaeSor * 129S7/SvEvBrd
|
abnormal aortic arch and aortic arch branch attachment |
J:89237
|
|
abnormal conotruncal ridge morphology |
J:89237
|
|
abnormal heart development |
J:89237
|
|
abnormal pharyngeal arch artery morphology |
J:89237
|
|
abnormal pulmonary artery morphology |
J:89237
|
|
aortopulmonary window |
J:89237
|
|
conotruncal ridge hypoplasia |
J:89237
|
|
embryonic lethality during organogenesis, incomplete penetrance |
J:89237
|
|
hydrops fetalis |
J:89237
|
|
interrupted aortic arch, type b |
J:89237
|
|
pericardial effusion |
J:89237
|
|
perimembraneous ventricular septal defect |
J:89237
|
|
persistent truncus arteriosus |
J:89237
|
|
semilunar valve hypoplasia |
J:89237
|
Bnip3ltm1Gwd/Bnip3ltm1Gwd
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129 * 129S7/SvEvBrd
|
abnormal heart left ventricle morphology |
J:145086
|
|
abnormal response of heart to induced stress |
J:145086
|
|
cardiac fibrosis |
J:145086
|
|
decreased cardiomyocyte apoptosis |
J:145086
|
|
increased cardiac muscle contractility |
J:145086
|
Casz1tm1.1Flc/Casz1+
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
|
no abnormal phenotype detected |
J:221324
|
Casz1tm1.1Flc/Casz1tm1.1Flc
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
|
abnormal cell cycle checkpoint function |
J:221324
|
|
abnormal fetal cardiomyocyte physiology |
J:221324
|
|
abnormal heart apex morphology |
J:221324
|
|
abnormal heart development |
J:221324
|
|
abnormal heart left ventricle morphology |
J:221324
|
|
abnormal heart shape |
J:221324
|
|
abnormal heart ventricle morphology |
J:221324
|
|
abnormal interventricular septum morphology |
J:221324
|
|
decreased fetal cardiomyocyte number |
J:221324
|
|
decreased fetal cardiomyocyte proliferation |
J:221324
|
|
decreased mitotic index |
J:221324
|
|
dilated heart right atrium |
J:221324
|
|
distended pericardium |
J:221324
|
|
edema |
J:221324
|
|
embryonic lethality during organogenesis, complete penetrance |
J:221324
|
|
heart hypoplasia |
J:221324
|
|
hemorrhage |
J:221324
|
|
increased heart right atrium size |
J:221324
|
|
perimembraneous ventricular septal defect |
J:221324
|
|
poor circulation |
J:221324
|
|
thin myocardium |
J:221324
|
|
thin ventricular wall |
J:221324
|
|
trabecula carnea hypoplasia |
J:221324
|
Cdc42tm1.1Yizh/Cdc42+
Nkx2-5tm1Siz/Nkx2-5+
involves: 129S4/SvJaeSor
|
decreased cardiac output |
J:174208
|
|
decreased cardiac stroke volume |
J:174208
|
|
decreased ventricle muscle contractility |
J:174208
|
|
prolonged P wave |
J:174208
|
|
prolonged QRS complex duration |
J:174208
|
|
prolonged QT interval |
J:174208
|
Cdkn2btm1Bbd/Cdkn2btm1Bbd
Pbx1tm1Koss/Pbx1tm1Koss
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129P2/OlaHsd * 129S1/Sv
|
abnormal spleen mesenchyme morphology |
J:184521
|
|
abnormal spleen morphology |
J:184521
|
Daam1Gt(RRT390)Byg/Daam1Gt(RRT390)Byg
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
|
normal
cardiovascular system phenotype |
J:167714
|
|
decreased body size |
J:167714
|
|
decreased embryo size |
J:167714
|
|
normal
mortality/aging |
J:167714
|
Daam1tm1.1Tpy/Daam1tm1.1Tpy
Daam2tm1Tpy/Daam2tm1Tpy
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S1/Sv * 129S7/SvEvBrd
|
abnormal A band morphology |
J:228507
|
|
abnormal H zone morphology |
J:228507
|
|
abnormal heart left ventricle morphology |
J:228507
|
|
abnormal heart right ventricle morphology |
J:228507
|
|
abnormal I band morphology |
J:228507
|
|
abnormal intercalated disk morphology |
J:228507
|
|
abnormal myocardial fiber morphology |
J:228507
|
|
abnormal myocardial fiber physiology |
J:228507
|
|
abnormal myocardial trabeculae morphology |
J:228507
|
|
absent M line |
J:228507
|
|
absent Z line |
J:228507
|
|
normal
cardiovascular system phenotype |
J:228507
|
|
decreased left ventricle systolic pressure |
J:228507
|
|
decreased right ventricle systolic pressure |
J:228507
|
|
diffuse Z line |
J:228507
|
|
heart hypoplasia |
J:228507
|
Daam1tm1.1Tpy/Daam1tm1.1Tpy
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd
|
abnormal cardiac muscle tissue morphology |
J:228507
|
Daam1tm1.1Tpy/Daam1tm1.1Tpy
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S1/Sv * 129S7/SvEvBrd
|
abnormal diastolic filling velocity |
J:228507
|
|
abnormal heart left ventricle morphology |
J:228507
|
|
abnormal heart right ventricle morphology |
J:228507
|
|
abnormal myocardial trabeculae morphology |
J:228507
|
|
abnormal pulmonary pressure |
J:228507
|
|
normal
cardiovascular system phenotype |
J:228507
|
|
decreased right ventricle systolic pressure |
J:228507
|
|
thin ventricle myocardium compact layer |
J:228507
|
Daam1tm1.1Tpy/Daam1tm1.1Tpy
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Wnt5atm1Amc/Wnt5a+
involves: 129S1/Sv * 129S7/SvEvBrd
|
abnormal myocardial trabeculae morphology |
J:228507
|
|
thick myocardium compact layer |
J:228507
|
Daam1tm1.1Tpy/Daam1tm1.1Tpy
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Wnt5atm1Amc/Wnt5atm1Amc
involves: 129S1/Sv * 129S7/SvEvBrd
|
abnormal heart morphology |
J:228507
|
|
abnormal heart right ventricle morphology |
J:228507
|
|
abnormal interventricular septum morphology |
J:228507
|
|
abnormal myocardial trabeculae morphology |
J:228507
|
|
abnormal myocardium compact layer morphology |
J:228507
|
|
lethality throughout fetal growth and development, complete penetrance |
J:228507
|
Dicer1tm1Bdh/Dicer1tm1Bdh
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129 * 129S7/SvEvBrd * C57BL/6
|
abnormal cardiovascular system physiology |
J:211548
|
|
abnormal myocardium layer morphology |
J:211548
|
|
embryonic lethality during organogenesis, complete penetrance |
J:211548
|
|
pericardial edema |
J:211548
|
Dicer1tm1Bdh/Dicer1tm1Bdh
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129 * 129S1/Sv
|
abnormal cardiac outflow tract development |
J:156467
|
|
double outlet right ventricle |
J:156467
|
|
embryonic lethality during organogenesis, complete penetrance |
J:156467
|
|
thin ventricle myocardium compact layer |
J:156467
|
|
ventricular septal defect |
J:156467
|
Ehmt1tm2Yshk/Ehmt1tm2Yshk
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd
|
abnormal mitral valve cusp morphology |
J:204470
|
|
absent tricuspid valve cusps |
J:204470
|
|
atrioventricular septal defect |
J:204470
|
|
decreased atrioventricular cushion size |
J:204470
|
|
neonatal lethality, incomplete penetrance |
J:204470
|
|
premature death |
J:204470
|
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd
|
abnormal heart development |
J:109474
|
|
abnormal splanchnic mesoderm morphology |
J:109474
|
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129P2/OlaHsd * 129S7/SvEvBrd
|
abnormal heart tube morphology |
J:109474
|
|
absent cardiac outflow tract |
J:109474
|
|
absent heart right ventricle |
J:109474
|
|
dilated heart atrium |
J:109474
|
|
dilated heart left ventricle |
J:109474
|
|
embryonic lethality during organogenesis, complete penetrance |
J:109474
|
|
pharyngeal arch hypoplasia |
J:109474
|
Fgf8tm1.3Mrt/Fgf8tm2Mrt
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129 * 129S7/SvEvBrd
|
abnormal heart development |
J:109474
|
|
abnormal heart morphology |
J:109474
|
|
abnormal neural crest cell morphology |
J:109474
|
|
abnormal pharyngeal arch mesenchyme morphology |
J:109474
|
|
abnormal pharyngeal arch morphology |
J:109474
|
|
abnormal splanchnic mesoderm morphology |
J:109474
|
|
decreased mitotic index |
J:109474
|
|
normal
mortality/aging |
J:109474
|
Fkbp1atm1.1Shou/Fkbp1atm1Zuk
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd
|
abnormal heart ventricle morphology |
J:195489
|
|
lethality throughout fetal growth and development, complete penetrance |
J:195489
|
Foxc2tm1.1Miu/Foxc2tm1.1Miu
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
|
normal
craniofacial phenotype |
J:316530
|
|
interrupted aortic arch, type b |
J:316530
|
|
neonatal lethality, complete penetrance |
J:316530
|
|
perimembraneous ventricular septal defect |
J:316530
|
|
normal
skeleton phenotype |
J:316530
|
Foxp1tm2.1Eem/Foxp1tm2.1Eem
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129 * C57BL/6 * SJL
|
abnormal heart development |
J:163662
|
|
abnormal sarcomere morphology |
J:163662
|
|
double outlet right ventricle |
J:163662
|
|
increased fetal cardiomyocyte proliferation |
J:163662
|
|
neonatal lethality, complete penetrance |
J:163662
|
|
thick interventricular septum |
J:163662
|
|
thick ventricular wall |
J:163662
|
|
ventricular septal defect |
J:163662
|
Frs2tm1Fwan/Frs2tm1Fwan
Nkx2-5tm1(cre)Rjs/?
involves: 129S7/SvEvBrd * C57BL/6
|
abnormal interventricular septum morphology |
J:128712
|
Gas2l3tm1c(EUCOMM)Hmgu/Gas2l3tm1c(EUCOMM)Hmgu
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6N
|
cardiac interstitial fibrosis |
J:244087
|
|
dilated cardiomyopathy |
J:244087
|
|
dilated heart |
J:244087
|
|
increased heart weight |
J:244087
|
Gata4tm1.1Sad/Gata4tm1.1Sad
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S1/Sv * 129X1/SvJ * CD-1
|
increased cardiomyocyte apoptosis |
J:121367
|
|
prenatal lethality, complete penetrance |
J:121367
|
|
thin ventricular wall |
J:121367
|
Gata4tm1.1Wtp/Gata4tm1.1Wtp
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd
|
abnormal cardiac epithelial to mesenchymal transition |
J:99203
|
|
abnormal fetal cardiomyocyte proliferation |
J:99203
|
|
atrioventricular cushion hypoplasia |
J:99203
|
|
common ventricle |
J:99203
|
|
conotruncal ridge hypoplasia |
J:99203
|
|
embryonic growth retardation |
J:99203
|
|
heart hypoplasia |
J:99203
|
|
heart right ventricle hypoplasia |
J:99203
|
|
lethality throughout fetal growth and development, complete penetrance |
J:99203
|
|
pericardial effusion |
J:99203
|
Gata4tm1Sho/Gata4+
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S6/SvEvTac * 129S7/SvEvBrd
|
normal
cardiovascular system phenotype |
J:150452
|
Gata4tm1Sho/Gata4tm1.1Wtp
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S6/SvEvTac * 129S7/SvEvBrd
|
abnormal atrioventricular cushion morphology |
J:150452
|
|
abnormal coronary vessel morphology |
J:150452
|
|
hemorrhage |
J:150452
|
|
skin edema |
J:150452
|
|
thin myocardium compact layer |
J:150452
|
|
ventricular septal defect |
J:150452
|
Grk2tm1Gwd/Grk2tm1Gwd
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6
|
normal
cardiovascular system phenotype |
J:126501
|
|
decreased physiological sensitivity to xenobiotic |
J:126501
|
|
increased physiological sensitivity to xenobiotic |
J:126501
|
|
normal
mortality/aging |
J:126501
|
Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Nkx2-5tm1(cre)Rjs/Nkx2-5+
either: (involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S/SvEv * 129S7/SvEvBrd * CD-1)
|
absent heart |
J:103417
|
|
decreased embryo size |
J:103417
|
|
embryonic lethality during organogenesis, complete penetrance |
J:103417
|
Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd * C57BL/6
|
abnormal myocardial fiber morphology |
J:233994
|
|
abnormal myocardial fiber physiology |
J:233994
|
|
decreased cardiac muscle contractility |
J:233994
|
|
decreased myocardial fiber size |
J:233994
|
|
enlarged heart |
J:233994
|
|
increased cardiomyocyte apoptosis |
J:233994
|
|
increased fetal cardiomyocyte proliferation |
J:233994
|
|
increased heart weight |
J:233994
|
|
premature death |
J:233994
|
Hand1tm5Abfi/Hand1+
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd
|
abnormal cardiac outflow tract development |
J:311466
|
|
abnormal interventricular septum morphology |
J:311466
|
|
abnormal myocardial trabeculae morphology |
J:311466
|
|
cardiac edema |
J:311466
|
|
decreased heart right ventricle size |
J:311466
|
|
hemorrhage |
J:311466
|
|
increased cell death |
J:311466
|
|
lethality throughout fetal growth and development, complete penetrance |
J:311466
|
|
thin left ventricle myocardium compact layer |
J:311466
|
|
thin myocardium |
J:311466
|
|
ventricular septal defect |
J:311466
|
Hand2tm1Dsr/Hand2+
Nkx2-5tm1Wehi/Nkx2-5+
involves: C57BL/6
|
normal
mortality/aging |
J:72600
|
Hand2tm1Dsr/Hand2tm1Dsr
Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
|
abnormal blood vessel morphology |
J:72600
|
|
abnormal cardiac outflow tract development |
J:72600
|
|
abnormal heart atrium morphology |
J:72600
|
|
abnormal sinus venosus morphology |
J:72600
|
|
absent myocardial trabeculae |
J:72600
|
|
congestive heart failure |
J:72600
|
|
embryonic lethality during organogenesis, complete penetrance |
J:72600
|
|
pericardial effusion |
J:72600
|
|
ventricular hypoplasia |
J:72600
|
Hccstm1Tcc/Hccs+
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129S1/Sv
|
abnormal atrial thrombosis |
J:143285
|
|
abnormal fetal cardiomyocyte mitochondrial morphology |
J:143285
|
|
abnormal myocardial fiber physiology |
J:143285
|
|
abnormal myocardium layer morphology |
J:143285
|
|
abnormal respiratory electron transport chain |
J:143285
|
|
atrioventricular block |
J:143285
|
|
bundle branch block |
J:143285
|
|
cardiac interstitial fibrosis |
J:143285
|
|
dilated cardiomyopathy |
J:143285
|
|
dilated heart atrium |
J:143285
|
|
dilated heart left ventricle |
J:143285
|
|
dilated heart right ventricle |
J:143285
|
|
enlarged heart |
J:143285
|
|
premature death |
J:143285
|
|
sinoatrial block |
J:143285
|
|
thick ventricular wall |
J:143285
|
Hccstm1Tcc/Hccs+
Nkx2-5tm2(cre)Rph/Nkx2-5+
Tg(CAG-EGFP)D4Nagy/0
Tg(Hmgcr-lacZ)H253Sest/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
|
abnormal fetal cardiomyocyte morphology |
J:143285
|
|
abnormal fetal cardiomyocyte proliferation |
J:143285
|
|
decreased fetal cardiomyocyte size |
J:143285
|
Hccstm1Tcc/Hccstm1Tcc
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129S1/Sv
|
embryonic lethality during organogenesis, incomplete penetrance |
J:143285
|
Hccstm1Tcc/Y
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129S1/Sv
|
abnormal fetal cardiomyocyte mitochondrial morphology |
J:143285
|
|
abnormal fetal cardiomyocyte morphology |
J:143285
|
|
abnormal respiratory electron transport chain |
J:143285
|
|
decreased cardiac muscle glycogen level |
J:143285
|
|
decreased fetal cardiomyocyte proliferation |
J:143285
|
|
embryonic lethality during organogenesis, incomplete penetrance |
J:143285
|
Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129P2/OlaHsd * 129S7/SvEvBrd
|
embryonic growth retardation |
J:225226
|
|
hemorrhage |
J:225226
|
|
normal
mortality/aging |
J:225226
|
|
overriding aortic valve |
J:225226
|
|
thin myocardium |
J:225226
|
|
ventricular septal defect |
J:225226
|
Hspb7tm1.1Chen/Hspb7tm1.1Chen
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
|
abnormal heart morphology |
J:256653
|
|
embryonic lethality during organogenesis, complete penetrance |
J:256653
|
Mrtfbem1Dsr/Mrtfb+
Myh7em1Dsr/Myh7+
Nkx2-5em1Dsr/Nkx2-5+
involves: C57BL/6J
|
abnormal trabecula carnea morphology |
J:277399
|
|
increased response of heart to induced stress |
J:277399
|
|
thin ventricular wall |
J:277399
|
NipblGt(RRS564)Byg/Nipbl+
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * CD-1
|
abnormal heart morphology |
J:236978
|
|
atrial septal defect |
J:236978
|
|
persistent truncus arteriosus |
J:236978
|
|
ventricular septal defect |
J:236978
|
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Tbx1tm1Bld/Tbx1tm3Bld
involves: 129S7/SvEvBrd * C57BL/6
|
abnormal pharyngeal arch artery morphology |
J:91013
|
|
absent fourth pharyngeal arch artery |
J:91013
|
|
normal
craniofacial phenotype |
J:91013
|
|
decreased mitotic index |
J:91013
|
|
fourth pharyngeal arch artery hypoplasia |
J:91013
|
|
persistent truncus arteriosus |
J:91013
|
|
small thymus |
J:91013
|
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Nsd2tm1Ykan/Nsd2+
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
|
abnormal interatrial septum morphology |
J:150360
|
|
atrial septal defect |
J:150360
|
|
perimembraneous ventricular septal defect |
J:150360
|
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Zic3tm2.1Jwb/Y
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J
|
no abnormal phenotype detected |
J:192577
|
Nkx2-5tm1.1Wtp/Nkx2-5tm1.1Wtp
involves: 129S4/SvJae * C57BL/6 * SJL * Swiss Webster
|
no abnormal phenotype detected |
J:185868
|
Nkx2-5tm1Siz/Nkx2-5+
Nkx2-6tm1Siz/Nkx2-6tm1Siz
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
|
no abnormal phenotype detected |
J:69976
|
Nkx2-5tm1Siz/Nkx2-5tm1Siz
Nkx2-6tm1Siz/Nkx2-6+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
|
abnormal heart atrium morphology |
J:69976
|
|
abnormal pharynx morphology |
J:69976
|
|
absent atrioventricular cushions |
J:69976
|
|
embryonic lethality during organogenesis |
J:69976
|
Nkx2-5tm1Siz/Nkx2-5tm1Siz
Nkx2-6tm1Siz/Nkx2-6tm1Siz
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
|
abnormal heart atrium morphology |
J:69976
|
|
abnormal pharyngeal pouch morphology |
J:69976
|
|
absent atrioventricular cushions |
J:69976
|
|
decreased cell proliferation |
J:69976
|
|
embryonic growth retardation |
J:69976
|
|
embryonic lethality during organogenesis, complete penetrance |
J:69976
|
|
increased apoptosis |
J:69976
|
|
pericardial effusion |
J:69976
|
|
pharynx hypoplasia |
J:69976
|
Nkx2-5tm2(cre)Rph/Nkx2-5+
Pbx1tm1.1Koss/Pbx1tm1.1Koss
involves: 129P2/OlaHsd * 129S1/Sv
|
abnormal spleen morphology |
J:184521
|
|
spleen hypoplasia |
J:184521
|
Nkx2-5tm3Rph/Nkx2-5+
Tbx20tm1.1Rph/Tbx20+
involves: C57BL/6
|
cardiac fibrosis |
J:98489
|
|
dilated heart right ventricle |
J:98489
|
Nkx2-5tm4Rph/Nkx2-5+
Tbx20tm1.1Rph/Tbx20+
involves: 129S1/Sv * C57BL/6
|
atrial septal defect |
J:98489
|
|
cardiac fibrosis |
J:98489
|
|
decreased heart left ventricle wall thickness |
J:98489
|
|
decreased ventricle muscle contractility |
J:98489
|
|
dilated cardiomyopathy |
J:98489
|
|
dilated heart left atrium |
J:98489
|
|
dilated heart left ventricle |
J:98489
|
|
myocardial fiber disarray |
J:98489
|
|
preweaning lethality, incomplete penetrance |
J:98489
|
Nkx2-5tm4Rph/Nkx2-5tm4Rph
Tbx20tm1.1Rph/Tbx20tm1.1Rph
involves: 129S1/Sv * C57BL/6
|
abnormal heart tube morphology |
J:98489
|
Nkx2-5tm6Rph/Nkx2-5+
Tg(DMPK/tetO-EGFP/DMPK)5-313Masm/0
involves: 129S1/Sv * FVB/N
|
impaired muscle relaxation |
J:131302
|
|
prolonged PR interval |
J:131302
|
Nkx2-5tm6Rph/Nkx2-5+
Tg(DMPK/tetO-EGFP/DMPK)5-313Masm/Tg(DMPK/tetO-EGFP/DMPK)5-313Masm
involves: 129S1/Sv * FVB/N
|
abnormal atrioventricular node conduction |
J:131302
|
|
impaired muscle relaxation |
J:131302
|
Pbx1tm1Koss/Pbx1tm1Koss
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129P2/OlaHsd * 129S1/Sv
|
abnormal spleen mesenchyme morphology |
J:184521
|
|
abnormal spleen morphology |
J:184521
|
|
spleen hypoplasia |
J:184521
|
Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129P2/OlaHsd * 129S/Sv * 129S1/Sv
|
abnormal spleen morphology |
J:184521
|
|
spleen hypoplasia |
J:184521
|
Prox1tm2Gco/Prox1tm2Gco
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S1/Sv * 129S7/SvEvBrd
|
abnormal atrial thrombosis |
J:212185
|
|
abnormal cardiac thrombosis |
J:212185
|
|
abnormal heart morphology |
J:212185
|
|
abnormal interventricular septum morphology |
J:212185
|
|
abnormal interventricular septum muscular part morphology |
J:212185
|
|
abnormal myocardial fiber morphology |
J:212185
|
|
abnormal ventricular thrombosis |
J:212185
|
|
decreased cardiac muscle contractility |
J:212185
|
|
dilated cardiomyopathy |
J:212185
|
|
dilated heart |
J:212185
|
|
enlarged heart |
J:212185
|
|
interventricular septum membranous part aneurysm |
J:212185
|
|
postnatal lethality, incomplete penetrance |
J:212185
|
|
premature death |
J:212185
|
|
thick tricuspid valve cusps |
J:212185
|
|
thin myocardium |
J:212185
|
Shhtm1Chg/Shhtm2Amc
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
|
abnormal artery morphology |
J:135134
|
|
abnormal cardiac outflow tract development |
J:135134
|
|
abnormal neural crest cell apoptosis |
J:135134
|
|
abnormal neural crest cell migration |
J:135134
|
|
persistent truncus arteriosus |
J:135134
|
Smarcd3tm1.1Bbr/Smarcd3tm1.1Bbr
Nkx2-5tm1(cre)Rjs/Nkx2-5+
either: (involves: 129 * C57BL/6 * SJL) or (involves: 129 * C57BL/6 * ICR * SJL)
|
abnormal interventricular septum morphology |
J:257963
|
|
abnormal myocardial trabeculae morphology |
J:257963
|
|
lethality throughout fetal growth and development, complete penetrance |
J:257963
|
|
thin myocardium |
J:257963
|
|
thin ventricular wall |
J:257963
|
Smotm2Amc/Smotm2.1Amc
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd * 129X1/SvJ
|
abnormal artery morphology |
J:135134
|
|
abnormal cardiac outflow tract development |
J:135134
|
|
abnormal neural crest cell apoptosis |
J:135134
|
|
abnormal neural crest cell migration |
J:135134
|
|
persistent truncus arteriosus |
J:135134
|
Smyd2tm1.1Fben/Smyd2tm1.1Fben
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129S1/Sv * C57BL/6
|
normal
cardiovascular system phenotype |
J:158898
|
Sox7tm1.1Nat/Sox7tm1.1Nat
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129 * 129S1/Sv * C57BL/6 * SJL
|
abnormal cardiac epithelial to mesenchymal transition |
J:306193
|
|
atrioventricular cushion hypoplasia |
J:306193
|
Srsf4tm1c(EUCOMM)Wtsi/Srsf4tm1c(EUCOMM)Wtsi
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129S1/Sv * C57BL/6 * C57BL/6N
|
abnormal cardiovascular system physiology |
J:344969
|
|
abnormal fetal cardiomyocyte physiology |
J:344969
|
|
abnormal heart echocardiography feature |
J:344969
|
|
abnormal heart electrocardiography waveform feature |
J:344969
|
|
abnormal mitral valve flow |
J:344969
|
|
normal
cardiovascular system phenotype |
J:344969
|
|
enlarged heart |
J:344969
|
|
heart left ventricle hypertrophy |
J:344969
|
|
increased fetal cardiomyocyte size |
J:344969
|
|
increased heart left ventricle wall thickness |
J:344969
|
|
increased heart left ventricle weight |
J:344969
|
|
increased heart rate |
J:344969
|
|
increased heart weight |
J:344969
|
|
increased myocardial fiber size |
J:344969
|
|
increased QRS amplitude |
J:344969
|
|
increased response of heart to induced stress |
J:344969
|
|
prolonged QT interval |
J:344969
|
|
shortened ST segment |
J:344969
|
Yap1tm1.1Eno/Yap1tm1.1Eno
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S/SvEv
|
abnormal myocardium layer morphology |
J:189577
|
|
decreased heart rate |
J:189577
|
|
embryonic lethality during organogenesis, complete penetrance |
J:189577
|
|
thin myocardium |
J:189577
|
Zfpm2tm1Sho/Zfpm2tm2Sho
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S1/Sv * 129S7/SvEvBrd
|
abnormal atrioventricular cushion morphology |
J:150452
|
|
abnormal coronary vessel morphology |
J:150452
|
|
atrial septal defect |
J:150452
|
|
hemorrhage |
J:150452
|
|
lethality throughout fetal growth and development, complete penetrance |
J:150452
|
|
overriding aortic valve |
J:150452
|
|
pericardial effusion |
J:150452
|
|
skin edema |
J:150452
|
|
thin myocardium compact layer |
J:150452
|
|
ventricular septal defect |
J:150452
|
Zic3tm1.1Smwa/Y
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd
|
no abnormal phenotype detected |
J:194989
|
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