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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Nkx2-5
NK2 homeobox 5
MGI:97350
169 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Adam17tm1.1Wesh/Adam17tm1.1Wesh
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
abnormal myocardial trabeculae morphology J:210193
abnormal myocardium layer morphology J:210193
enlarged heart J:210193
normal mortality/aging J:210193
thin myocardium J:210193
Akap6tm1.1Mskf/Akap6tm1.1Mskf
Nkx2-5tm1(cre)Rjs/0
involves: 129S7/SvEvBrd * C57BL/6 * SJL
no abnormal phenotype detected J:214288
Atoh8tm1.1Mlkn/Atoh8tm1.1Mlkn
Gata4tm1.1Sad/Gata4+
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129 * C57BL/6
normal mortality/aging J:203454
Bmp2tm1Jfm/Bmp2tm1Jfm
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S4/SvJaeSor
abnormal cardiac epithelial to mesenchymal transition J:104417
abnormal cardiac jelly morphology J:104417
abnormal fetal atrioventricular canal morphology J:104417
abnormal myocardium layer morphology J:104417
embryonic growth retardation J:104417
embryonic lethality during organogenesis, complete penetrance J:104417
pericardial effusion J:104417
Bmp2tm1Vrs/Bmp2tm1Vrs
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129S1/Sv * C57BL/6
abnormal heart development J:110615
absent atrioventricular cushions J:110615
cardiac edema J:110615
decreased embryo size J:110615
embryonic lethality during organogenesis, complete penetrance J:110615
pericardial effusion J:110615
Bmp4tm1Jfm/Bmp4tm1.1Jfm
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S4/SvJaeSor
abnormal aortic arch and aortic arch branch attachment J:89237
abnormal conotruncal ridge morphology J:89237
abnormal heart development J:89237
abnormal pharyngeal arch artery morphology J:89237
abnormal pulmonary artery morphology J:89237
abnormal semilunar valve morphology J:89237
aortopulmonary window J:89237
embryonic lethality during organogenesis, incomplete penetrance J:89237
hydrops fetalis J:89237
interrupted aortic arch J:89237
pericardial effusion J:89237
perimembraneous ventricular septal defect J:89237
persistent truncus arteriosis J:89237
Bnip3ltm1Gwd/Bnip3ltm1Gwd
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129 * 129S7/SvEvBrd
abnormal heart left ventricle morphology J:145086
altered response of heart to induced stress J:145086
cardiac fibrosis J:145086
decreased cardiomyocyte apoptosis J:145086
increased cardiac muscle contractility J:145086
Casz1tm1.1Flc/Casz1+
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
normal no abnormal phenotype detected J:221324
Casz1tm1.1Flc/Casz1tm1.1Flc
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
abnormal cell cycle checkpoint function J:221324
abnormal fetal cardiomyocyte morphology J:221324
abnormal fetal cardiomyocyte physiology J:221324
abnormal heart apex morphology J:221324
abnormal heart development J:221324
abnormal heart left ventricle morphology J:221324
abnormal heart shape J:221324
abnormal heart ventricle morphology J:221324
abnormal interventricular septum morphology J:221324
decreased fetal cardiomyocyte proliferation J:221324
decreased mitotic index J:221324
dilated heart right atrium J:221324
distended pericardium J:221324
edema J:221324
embryonic lethality during organogenesis, complete penetrance J:221324
enlarged heart right atrium J:221324
heart hypoplasia J:221324
hemorrhage J:221324
perimembraneous ventricular septal defect J:221324
poor circulation J:221324
thin myocardium J:221324
thin ventricular wall J:221324
trabecula carnea hypoplasia J:221324
Cdc42tm1.1Yizh/Cdc42+
Nkx2-5tm1Siz/Nkx2-5+
involves: 129S4/SvJaeSor
decreased cardiac output J:174208
decreased cardiac stroke volume J:174208
decreased ventricle muscle contractility J:174208
prolonged P wave J:174208
prolonged QRS complex duration J:174208
prolonged QT interval J:174208
Cdkn2btm1Bbd/Cdkn2btm1Bbd
Pbx1tm1Koss/Pbx1tm1Koss
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129P2/OlaHsd * 129S1/Sv
abnormal spleen mesenchyme morphology J:184521
abnormal spleen morphology J:184521
Daam1Gt(RRT390)Byg/Daam1Gt(RRT390)Byg
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
normal cardiovascular system phenotype J:167714
decreased body size J:167714
decreased embryo size J:167714
normal mortality/aging J:167714
Daam1tm1.1Tpy/Daam1tm1.1Tpy
Daam2tm1Tpy/Daam2tm1Tpy
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S1/Sv * 129S7/SvEvBrd
abnormal A band morphology J:228507
abnormal H zone morphology J:228507
abnormal heart left ventricle morphology J:228507
abnormal heart right ventricle morphology J:228507
abnormal I band morphology J:228507
abnormal intercalated disk morphology J:228507
abnormal myocardial fiber morphology J:228507
abnormal myocardial fiber physiology J:228507
abnormal myocardial trabeculae morphology J:228507
absent M line J:228507
absent Z line J:228507
normal cardiovascular system phenotype J:228507
decreased left ventricle systolic pressure J:228507
decreased right ventricle systolic pressure J:228507
diffuse Z line J:228507
heart hypoplasia J:228507
Daam1tm1.1Tpy/Daam1tm1.1Tpy
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd
abnormal cardiac muscle tissue morphology J:228507
Daam1tm1.1Tpy/Daam1tm1.1Tpy
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S1/Sv * 129S7/SvEvBrd
abnormal diastolic filling velocity J:228507
abnormal heart left ventricle morphology J:228507
abnormal heart right ventricle morphology J:228507
abnormal myocardial trabeculae morphology J:228507
abnormal pulmonary pressure J:228507
normal cardiovascular system phenotype J:228507
decreased right ventricle systolic pressure J:228507
thin ventricle myocardium compact layer J:228507
Daam1tm1.1Tpy/Daam1tm1.1Tpy
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Wnt5atm1Amc/Wnt5a+
involves: 129S1/Sv * 129S7/SvEvBrd
abnormal myocardial trabeculae morphology J:228507
thick myocardium compact layer J:228507
Daam1tm1.1Tpy/Daam1tm1.1Tpy
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Wnt5atm1Amc/Wnt5atm1Amc
involves: 129S1/Sv * 129S7/SvEvBrd
abnormal heart morphology J:228507
abnormal heart right ventricle morphology J:228507
abnormal interventricular septum morphology J:228507
abnormal myocardial trabeculae morphology J:228507
abnormal myocardium compact layer morphology J:228507
lethality throughout fetal growth and development, complete penetrance J:228507
Dicer1tm1Bdh/Dicer1tm1Bdh
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129 * 129S7/SvEvBrd * C57BL/6
abnormal cardiovascular system physiology J:211548
abnormal myocardium layer morphology J:211548
embryonic lethality during organogenesis, complete penetrance J:211548
pericardial edema J:211548
Ehmt1tm2Yshk/Ehmt1tm2Yshk
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd
abnormal mitral valve cusp morphology J:204470
absent tricuspid valve cusps J:204470
atrioventricular septal defect J:204470
decreased atrioventricular cushion size J:204470
neonatal lethality, incomplete penetrance J:204470
premature death J:204470
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd
abnormal heart development J:109474
abnormal splanchnic mesoderm morphology J:109474
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129P2/OlaHsd * 129S7/SvEvBrd
abnormal heart tube morphology J:109474
absent cardiac outflow tract J:109474
absent heart right ventricle J:109474
dilated heart atrium J:109474
dilated heart left ventricle J:109474
embryonic lethality during organogenesis, complete penetrance J:109474
pharyngeal arch hypoplasia J:109474
Fgf8tm1.3Mrt/Fgf8tm2Mrt
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129 * 129S7/SvEvBrd
abnormal heart development J:109474
abnormal heart morphology J:109474
abnormal neural crest cell morphology J:109474
abnormal pharyngeal arch mesenchyme morphology J:109474
abnormal pharyngeal arch morphology J:109474
abnormal splanchnic mesoderm morphology J:109474
decreased mitotic index J:109474
normal mortality/aging J:109474
Fkbp1atm1.1Shou/Fkbp1atm1Zuk
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd
abnormal heart ventricle morphology J:195489
lethality throughout fetal growth and development, complete penetrance J:195489
Foxp1tm2.1Eem/Foxp1tm2.1Eem
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129 * C57BL/6 * SJL
abnormal heart development J:163662
abnormal sarcomere morphology J:163662
double outlet right ventricle J:163662
increased fetal cardiomyocyte proliferation J:163662
neonatal lethality, complete penetrance J:163662
thick interventricular septum J:163662
thick ventricular wall J:163662
ventricular septal defect J:163662
Frs2tm1Fwan/Frs2tm1Fwan
Nkx2-5tm1(cre)Rjs/?
involves: 129S7/SvEvBrd * C57BL/6
abnormal interventricular septum morphology J:128712
Gas2l3tm1c(EUCOMM)Hmgu/Gas2l3tm1c(EUCOMM)Hmgu
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6N
cardiac interstitial fibrosis J:244087
dilated cardiomyopathy J:244087
dilated heart J:244087
increased heart weight J:244087
Gata4tm1.1Sad/Gata4tm1.1Sad
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S1/Sv * 129X1/SvJ * CD-1
increased cardiomyocyte apoptosis J:121367
prenatal lethality, complete penetrance J:121367
thin ventricular wall J:121367
Gata4tm1.1Wtp/Gata4tm1.1Wtp
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd
abnormal cardiac epithelial to mesenchymal transition J:99203
abnormal fetal cardiomyocyte proliferation J:99203
common ventricle J:99203
conotruncal ridge hypoplasia J:99203
decreased atrioventricular cushion size J:99203
embryonic growth retardation J:99203
heart hypoplasia J:99203
heart right ventricle hypoplasia J:99203
lethality throughout fetal growth and development, complete penetrance J:99203
pericardial effusion J:99203
Gata4tm1Sho/Gata4+
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S6/SvEvTac * 129S7/SvEvBrd
normal cardiovascular system phenotype J:150452
Gata4tm1Sho/Gata4tm1.1Wtp
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S6/SvEvTac * 129S7/SvEvBrd
abnormal atrioventricular cushion morphology J:150452
abnormal coronary vessel morphology J:150452
hemorrhage J:150452
skin edema J:150452
thin myocardium compact layer J:150452
ventricular septal defect J:150452
Grk2tm1Gwd/Grk2tm1Gwd
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6
normal cardiovascular system phenotype J:126501
decreased physiological sensitivity to xenobiotic J:126501
increased physiological sensitivity to xenobiotic J:126501
normal mortality/aging J:126501
Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Nkx2-5tm1(cre)Rjs/Nkx2-5+
either: (involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6) or (involves: 129S/SvEv * 129S7/SvEvBrd * CD-1)
absent heart J:103417
decreased embryo size J:103417
embryonic lethality during organogenesis, complete penetrance J:103417
Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd * C57BL/6
abnormal myocardial fiber morphology J:233994
abnormal myocardial fiber physiology J:233994
decreased cardiac muscle contractility J:233994
enlarged heart J:233994
increased cardiomyocyte apoptosis J:233994
increased fetal cardiomyocyte proliferation J:233994
increased heart weight J:233994
premature death J:233994
small myocardial fiber J:233994
Hand2tm1Dsr/Hand2+
Nkx2-5tm1Wehi/Nkx2-5+
involves: C57BL/6
normal mortality/aging J:72600
Hand2tm1Dsr/Hand2tm1Dsr
Nkx2-5tm1Wehi/Nkx2-5tm1Wehi
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
abnormal blood vessel morphology J:72600
abnormal cardiac outflow tract development J:72600
abnormal heart atrium morphology J:72600
abnormal sinus venosus morphology J:72600
absent myocardial trabeculae J:72600
congestive heart failure J:72600
embryonic lethality during organogenesis, complete penetrance J:72600
pericardial effusion J:72600
ventricular hypoplasia J:72600
Hccstm1Tcc/Hccs+
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129S1/Sv
abnormal atrial thrombosis J:143285
abnormal fetal cardiomyocyte morphology J:143285
abnormal myocardial fiber physiology J:143285
abnormal myocardium layer morphology J:143285
abnormal respiratory electron transport chain J:143285
atrioventricular block J:143285
bundle branch block J:143285
cardiac interstitial fibrosis J:143285
dilated cardiomyopathy J:143285
dilated heart atrium J:143285
dilated heart left ventricle J:143285
dilated heart right ventricle J:143285
enlarged heart J:143285
premature death J:143285
sinoatrial block J:143285
thick ventricular wall J:143285
Hccstm1Tcc/Hccs+
Nkx2-5tm2(cre)Rph/Nkx2-5+
Tg(CAG-EGFP)D4Nagy/0
Tg(Hmgcr-lacZ)H253Sest/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
abnormal fetal cardiomyocyte morphology J:143285
abnormal fetal cardiomyocyte proliferation J:143285
Hccstm1Tcc/Hccstm1Tcc
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129S1/Sv
embryonic lethality during organogenesis, incomplete penetrance J:143285
Hccstm1Tcc/Y
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129S1/Sv
abnormal fetal cardiomyocyte morphology J:143285
abnormal fetal cardiomyocyte proliferation J:143285
abnormal respiratory electron transport chain J:143285
decreased glycogen level J:143285
embryonic lethality during organogenesis, incomplete penetrance J:143285
Hic2Gt(E225A08)1.1Wrst/Hic2Gt(E225A08)1.1Wrst
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129P2/OlaHsd * 129S7/SvEvBrd
embryonic growth retardation J:225226
hemorrhage J:225226
normal mortality/aging J:225226
overriding aortic valve J:225226
thin myocardium J:225226
ventricular septal defect J:225226
Hspb7tm1.1Chen/Hspb7tm1.1Chen
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
abnormal heart morphology J:256653
embryonic lethality during organogenesis, complete penetrance J:256653
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Tbx1tm1Bld/Tbx1tm3Bld
involves: 129S7/SvEvBrd * C57BL/6
abnormal pharyngeal arch artery morphology J:91013
absent fourth pharyngeal arch artery J:91013
normal craniofacial phenotype J:91013
decreased mitotic index J:91013
fourth pharyngeal arch artery hypoplasia J:91013
persistent truncus arteriosis J:91013
small thymus J:91013
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Nsd2tm1Ykan/Nsd2+
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
abnormal interatrial septum morphology J:150360
atrial septal defect J:150360
perimembraneous ventricular septal defect J:150360
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Zic3tm2.1Jwb/Y
involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6J
no abnormal phenotype detected J:192577
Nkx2-5tm1.1Gum/Nkx2-5tm1.1Gum
Tg(CAG-cre/Esr1*)5Amc/0
involves: C57BL/6J
abnormal pyloric sphincter morphology J:228275
abnormal stomach smooth muscle circular layer morphology J:228275
abnormal stomach smooth muscle outer longitudinal layer morphology J:228275
decreased cell proliferation J:228275
increased apoptosis J:228275
Nkx2-5tm1Siz/Nkx2-5+
Nkx2-6tm1Siz/Nkx2-6tm1Siz
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
no abnormal phenotype detected J:69976
Nkx2-5tm1Siz/Nkx2-5tm1Siz
Nkx2-6tm1Siz/Nkx2-6+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
abnormal heart atrium morphology J:69976
abnormal pharynx morphology J:69976
absent atrioventricular cushions J:69976
embryonic lethality during organogenesis J:69976
Nkx2-5tm1Siz/Nkx2-5tm1Siz
Nkx2-6tm1Siz/Nkx2-6tm1Siz
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
abnormal heart atrium morphology J:69976
abnormal pharyngeal pouch morphology J:69976
absent atrioventricular cushions J:69976
decreased cell proliferation J:69976
embryonic growth retardation J:69976
embryonic lethality during organogenesis, complete penetrance J:69976
increased apoptosis J:69976
pericardial effusion J:69976
pharynx hypoplasia J:69976
Nkx2-5tm2(cre)Rph/Nkx2-5+
Pbx1tm1.1Koss/Pbx1tm1.1Koss
involves: 129P2/OlaHsd * 129S1/Sv
abnormal spleen morphology J:184521
spleen hypoplasia J:184521
Nkx2-5tm3Rph/Nkx2-5+
Tbx20tm1.1Rph/Tbx20+
involves: C57BL/6
cardiac fibrosis J:98489
dilated heart right ventricle J:98489
Nkx2-5tm4Rph/Nkx2-5+
Tbx20tm1.1Rph/Tbx20+
involves: 129S1/Sv * C57BL/6
atrial septal defect J:98489
cardiac fibrosis J:98489
decreased ventricle muscle contractility J:98489
dilated cardiomyopathy J:98489
dilated heart atrium J:98489
dilated heart left ventricle J:98489
disorganized myocardium J:98489
preweaning lethality, incomplete penetrance J:98489
thin ventricular wall J:98489
Nkx2-5tm4Rph/Nkx2-5tm4Rph
Tbx20tm1.1Rph/Tbx20tm1.1Rph
involves: 129S1/Sv * C57BL/6
abnormal heart tube morphology J:98489
Nkx2-5tm6Rph/Nkx2-5+
Tg(DMPK/tetO-EGFP/DMPK)5-313Masm/0
involves: 129S1/Sv * FVB/N
impaired muscle relaxation J:131302
prolonged PR interval J:131302
Nkx2-5tm6Rph/Nkx2-5+
Tg(DMPK/tetO-EGFP/DMPK)5-313Masm/Tg(DMPK/tetO-EGFP/DMPK)5-313Masm
involves: 129S1/Sv * FVB/N
abnormal atrioventricular node conduction J:131302
impaired muscle relaxation J:131302
Pbx1tm1Koss/Pbx1tm1Koss
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129P2/OlaHsd * 129S1/Sv
abnormal spleen mesenchyme morphology J:184521
abnormal spleen morphology J:184521
spleen hypoplasia J:184521
Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129P2/OlaHsd * 129S/Sv * 129S1/Sv
abnormal spleen morphology J:184521
spleen hypoplasia J:184521
Prox1tm2Gco/Prox1tm2Gco
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S1/Sv * 129S7/SvEvBrd
abnormal atrial thrombosis J:212185
abnormal cardiac thrombosis J:212185
abnormal heart morphology J:212185
abnormal interventricular septum morphology J:212185
abnormal interventricular septum muscular part morphology J:212185
abnormal myocardial fiber morphology J:212185
decreased cardiac muscle contractility J:212185
dilated cardiomyopathy J:212185
dilated heart J:212185
enlarged heart J:212185
interventricular septum membranous part aneurysm J:212185
postnatal lethality, incomplete penetrance J:212185
premature death J:212185
thick tricuspid valve cusps J:212185
thin myocardium J:212185
Shhtm1Chg/Shhtm2Amc
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
abnormal artery morphology J:135134
abnormal cardiac outflow tract development J:135134
abnormal neural crest cell apoptosis J:135134
abnormal neural crest cell migration J:135134
persistent truncus arteriosis J:135134
Smotm2Amc/Smotm2.1Amc
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd * 129X1/SvJ
abnormal artery morphology J:135134
abnormal cardiac outflow tract development J:135134
abnormal neural crest cell apoptosis J:135134
abnormal neural crest cell migration J:135134
persistent truncus arteriosis J:135134
Smyd2tm1.1Fben/Smyd2tm1.1Fben
Nkx2-5tm2(cre)Rph/Nkx2-5+
involves: 129S1/Sv * C57BL/6
normal cardiovascular system phenotype J:158898
Yap1tm1.1Eno/Yap1tm1.1Eno
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S/SvEv
abnormal myocardium layer morphology J:189577
decreased heart rate J:189577
embryonic lethality during organogenesis, complete penetrance J:189577
thin myocardium J:189577
Zfpm2tm1Sho/Zfpm2tm2Sho
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S1/Sv * 129S7/SvEvBrd
abnormal atrioventricular cushion morphology J:150452
abnormal coronary vessel morphology J:150452
atrial septal defect J:150452
hemorrhage J:150452
lethality throughout fetal growth and development, complete penetrance J:150452
overriding aortic valve J:150452
pericardial effusion J:150452
skin edema J:150452
thin myocardium compact layer J:150452
ventricular septal defect J:150452
Zic3tm1.1Smwa/Y
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd
no abnormal phenotype detected J:194989

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/09/2019
MGI 6.14
The Jackson Laboratory