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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Myh6
myosin, heavy polypeptide 6, cardiac muscle, alpha
MGI:97255
46 phenotypes from 7 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Myh6tm1.1Jpsc/Myh6+
involves: 129
cardiac hypertrophy J:247162
normal cardiovascular system phenotype J:247162
increased physiological sensitivity to xenobiotic J:247162
Myh6tm1.1Jpsc/Myh6tm1.1Jpsc
involves: 129
normal cardiovascular system phenotype J:247162
Myh6tm1.1Jpsc/Myh6tm2Jse
involves: 129
abnormal cardiac muscle relaxation J:247162
abnormal cardiovascular system physiology J:247162
abnormal heart echocardiography feature J:247162
cardiac fibrosis J:247162
cardiac hypertrophy J:247162
decreased cardiac muscle contractility J:247162
decreased cardiac stroke volume J:247162
enlarged myocardial fiber J:247162
increased heart weight J:247162
myocardium hypertrophy J:247162
premature death J:247162
thick ventricular wall J:247162
Myh6tm1Ces/Myh6+
involves: 129S/SvEv * 129X1/SvJ
abnormal cardiac muscle relaxation J:114549
decreased cardiac muscle contractility J:114549
dilated cardiomyopathy J:114549
dilated heart left ventricle J:114549
Myh6tm1Ces/Myh6tm1Ces
involves: 129S/SvEv * 129X1/SvJ
decreased cardiac muscle contractility J:114549
dilated cardiomyopathy J:114549
dilated heart left ventricle J:114549
Myh6tm1Jse/Myh6+
129S.129X1-Myh6tm1Jse
abnormal cardiovascular system physiology J:104363
abnormal heart left ventricle morphology J:104363
cardiac fibrosis J:104363
cardiac hypertrophy J:104363
disorganized myocardium J:104363
increased cardiac muscle contractility J:104363
irregular heartbeat J:104363
Myh6tm1Jse/Myh6+
involves: 129X1/SvJ
abnormal enzyme/coenzyme activity J:95600
abnormal heart atrium morphology J:32960
abnormal heart morphology J:32960
abnormal heart ventricle pressure J:32960, J:47028
abnormal locomotor activation J:32960
abnormal myocardial fiber morphology J:32960, J:95600
abnormal myocardial fiber physiology J:95600
cardiac fibrosis J:95600
cardiac interstitial fibrosis J:32960
decreased cardiac output J:32960
disorganized myocardium J:32960
irregular heartbeat J:32960, J:47028
Myh6tm1Jse/Myh6tm1Jse
involves: 129X1/SvJ
postnatal lethality, complete penetrance J:32960
Myh6tm1Jse/Myh6tm1Jse
involves: 129X1/SvJ * Black Swiss
abnormal atrial thrombosis J:51939
abnormal myocardial fiber morphology J:51939
decreased ventricle muscle contractility J:51939
dilated cardiomyopathy J:51939
dilated heart atrium J:51939
dilated heart left ventricle J:51939
disorganized myocardium J:51939
dystrophic cardiac calcinosis J:51939
myocardium necrosis J:51939
postnatal lethality, complete penetrance J:51939
thin ventricular wall J:51939
Myh6tm1Rbns/Myh6+
involves: 129P2/OlaHsd
abnormal heart ventricle morphology J:36089
abnormal myocardial fiber morphology J:36089
abnormal myocardium layer morphology J:36089
cardiac fibrosis J:36089
decreased cardiac muscle contractility J:36089
decreased left ventricle diastolic pressure J:36089
decreased left ventricle systolic pressure J:36089
Myh6tm1Rbns/Myh6tm1Rbns
involves: 129P2/OlaHsd
embryonic lethality during organogenesis, complete penetrance J:36089
Myh6tm2Ces/Myh6+
involves: 129S/SvEv * 129X1/SvJ
decreased cardiac muscle contractility J:114549
dilated cardiomyopathy J:114549
dilated heart left ventricle J:114549
Myh6tm2Ces/Myh6tm2Ces
involves: 129S/SvEv * 129X1/SvJ
decreased cardiac muscle contractility J:114549
dilated cardiomyopathy J:114549
dilated heart left ventricle J:114549
Myh6tm2Jse/Myh6+
involves: 129
abnormal heart echocardiography feature J:247162
cardiac hypertrophy J:247162
cardiac interstitial fibrosis J:247162
disorganized myocardium J:247162
increased cardiac muscle contractility J:247162
thick ventricular wall J:247162
Myh6tm2Jse/Myh6+
involves: 129S1/Sv
abnormal enzyme/coenzyme activity J:95600
abnormal myocardial fiber morphology J:95600
abnormal myocardial fiber physiology J:95600
cardiac fibrosis J:95600
Myh6tm2Jse/Myh6tm2Jse
involves: 129
calcified myocardium J:247162
cardiac hypertrophy J:247162
disorganized myocardium J:247162
enlarged heart atrium J:247162
increased cardiomyocyte apoptosis J:247162
postnatal lethality, complete penetrance J:247162
Myh6tm3.1Jse/Myh6+
involves: 129
abnormal heart echocardiography feature J:247162
cardiac hypertrophy J:247162
cardiac interstitial fibrosis J:247162
disorganized myocardium J:247162
increased cardiac muscle contractility J:247162
thick ventricular wall J:247162
Myh6tm3.1Jse/Myh6+
involves: 129X1/SvJ
abnormal cardiovascular system physiology J:165269
cardiac fibrosis J:165269
cardiomyopathy J:165269
heart left ventricle hypertrophy J:165269
increased physiological sensitivity to xenobiotic J:165269
thick ventricular wall J:165269
Myh6tm3.1Jse/Myh6tm3.1Jse
involves: 129
calcified myocardium J:247162
cardiac hypertrophy J:247162
disorganized myocardium J:247162
enlarged heart atrium J:247162
increased cardiomyocyte apoptosis J:247162
postnatal lethality, complete penetrance J:247162

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory