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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Mapt
microtubule-associated protein tau
MGI:97180
227 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Apptm1Ck/Apptm1Ck
Psen1tm1Mpm/Psen1tm1Mpm
Tg(MAPT)8cPdav/0
B6.Cg-Psen1tm1Mpm Apptm1Ck Tg(MAPT)8cPdav
amyloid beta deposits J:209782
enhanced contextual conditioning behavior J:209782
hypoactivity J:209782
increased anxiety-related response J:209782
increased fear-related response J:209782
tau protein deposits J:209782
Bdnftm1Msd/Bdnftm1Msd
Mapttm1(cre)Nagy/Mapt+
involves: 129S1/Sv * 129X1/SvJ
normal mortality/aging J:131394
normal nervous system phenotype J:131394
reduced long term potentiation J:131394
Bdnftm1Yab/Bdnftm1Yab
Mapttm1(cre)Nagy/Mapt+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
abnormal dendrite morphology J:157932
abnormal locomotor activation J:157932
abnormal neuron morphology J:157932
abnormal optic nerve morphology J:157932
decreased body weight J:157932
decreased brain size J:157932
decreased brain weight J:157932
decreased striatum area J:157932
increased anxiety-related response J:157932
increased body weight J:157932
limb grasping J:157932
postnatal growth retardation J:157932
postnatal lethality, complete penetrance J:157932
Cbfbtm2.1Ddg/Cbfbtm2.1Ddg
Mapttm2Arbr/?
H2az2Tg(Wnt1-cre)11Rth/?
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CBA/J
abnormal axon morphology J:226826
abnormal craniofacial development J:226826
abnormal nociceptor morphology J:226826
abnormal sensory neuron innervation pattern J:226826
perinatal lethality J:226826
Cbfbtm2.1Ddg/Cbfbtm2.1Ddg
Mapttm2Arbr/?
Runx1tm1(cre/Esr1*)Ims/?
involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj
abnormal mechanoreceptor morphology J:226826
Chattm2(cre)Lowl/Chat+
Mapttm2(FUS)Neas/Mapt+
B6.129-Mapttm2(FUS)Neas Chattm2(cre)Lowl
abnormal neuromuscular synapse morphology J:232167
motor neuron degeneration J:232167
Chattm2(cre)Lowl/Chat+
Mapttm3(FUS)Neas/Mapt+
B6.129-Mapttm3(FUS)Neas Chattm2(cre)Lowl
abnormal neuromuscular synapse morphology J:232167
motor neuron degeneration J:232167
Cx3cr1tm1Litt/Cx3cr1+
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/0
Tg(Thy1-YFP)HJrs/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
abnormal microglial cell morphology J:159680
abnormal microglial cell physiology J:159680
neuron degeneration J:159680
Cx3cr1tm1Litt/Cx3cr1tm1Litt
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/0
Tg(Thy1-YFP)HJrs/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
normal nervous system phenotype J:159680
enu67/enu67+
Tg(Thy1-MAPT*K369I)K3Gotz/0
involves: BALB/c * C57BL/6 * DBA/2
slow postnatal weight gain J:196547
enu164/enu164+
Tg(Thy1-MAPT*K369I)K3Gotz/0
involves: BALB/c * C57BL/6 * DBA/2
abnormal gait J:196547
abnormal motor capabilities/coordination/movement J:196547
limb grasping J:196547
tremors J:196547
Fustm1a(EUCOMM)Wtsi/Fustm1c(EUCOMM)Wtsi
Mapttm3.1(FUS)Neas/Mapt+
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
involves: 129 * C3H * C57BL/6 * C57BL/6N
abnormal neuromuscular synapse morphology J:232167
Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno/Hprt+
Tg(PSEN1)5Dbo/0
involves: 129P2/OlaHsd
abnormal brain wave pattern J:180977
abnormal glucose homeostasis J:180977
abnormal learning/memory/conditioning J:180977
abnormal long term potentiation J:180977
abnormal motor coordination/balance J:180977
abnormal short term object recognition memory J:180977
abnormal spatial reference memory J:180977
abnormal spatial working memory J:180977
decreased paired-pulse facilitation J:180977
fragmentation of sleep/wake states J:180977
hyperactivity J:180977
normal nervous system phenotype J:180977
Hprttm1(MAPT)Dph/Y
involves: 129P2/OlaHsd * C57BL/6
abnormal autophagy J:263643
abnormal hippocampus morphology J:263643
abnormal hippocampus physiology J:263643
abnormal skeletal muscle fiber morphology J:263643
normal behavior/neurological phenotype J:263643
decreased grip strength J:263643
normal growth/size/body region phenotype J:263643
impaired coordination J:263643
impaired spatial learning J:263643
kyphosis J:263643
limb grasping J:263643
paresis J:263643
premature death J:263643
skeletal muscle fiber degeneration J:263643
Lbx1tm2Cbm/Lbx1tm3.1(cre)Cbm
Mapttm2Arbr/Mapt+
involves: 129P2/OlaHsd
abnormal brainstem morphology J:121332
abnormal medulla oblongata morphology J:121332
abnormal neuron differentiation J:121332
abnormal neuron morphology J:121332
abnormal neuron specification J:121332
increased sensory neuron number J:121332
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
Tg(MAPT)8cPdav/0
B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
abnormal spatial learning J:172426
neurofibrillary tangles J:172426
normal taste/olfaction phenotype J:172426
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
Tg(MAPT)8cPdav/?
involves: 129S4/SvJae * C57BL/6 * Swiss Webster
abnormal neuron morphology J:84638
abnormal renal glomerulus morphology J:174270
abnormal spleen B cell follicle morphology J:174270
abnormal spleen red pulp morphology J:174270
amyloidosis J:174270
increased follicular lymphoma incidence J:174270
increased lymphoma incidence J:174270
tau protein deposits J:84638
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
Tg(Thy1-MAPT*)30Schd/0
involves: 129S4/SvJae * C57BL/6 * CBA
abnormal brain morphology J:169074
abnormal sciatic nerve morphology J:169074
abnormal spinal cord morphology J:169074
normal behavior/neurological phenotype J:169074
impaired coordination J:169074
normal nervous system phenotype J:169074
neurofibrillary tangles J:169074
premature death J:169074
Mapttm1(Mecp2)Jae/Mapt+
involves: 129/Sv * C57BL/6
no abnormal phenotype detected J:89593
Mapttm1(Mecp2)Jae/Mapt+
Mecp2tm1.1Jae/Mecp2+
involves: 129S4/SvJae * C57BL/6
normal behavior/neurological phenotype J:89593
normal growth/size/body region phenotype J:89593
normal nervous system phenotype J:89593
Mapttm1(Mecp2)Jae/Mapttm1(Mecp2)Jae
B6.Cg-Mapttm1(Mecp2)Jae
abnormal associative learning J:182685
abnormal contextual conditioning behavior J:182685
abnormal cued conditioning behavior J:182685
abnormal miniature excitatory postsynaptic currents J:182685
abnormal object recognition memory J:182685
decreased body weight J:182685
enhanced paired-pulse facilitation J:182685
impaired coordination J:182685
increased anxiety-related response J:182685
reduced long term potentiation J:182685
Mapttm1(Mecp2)Jae/Mapttm1(Mecp2)Jae
involves: 129/Sv * C57BL/6
abnormal sexual interaction J:89593
ataxia J:89593
cachexia J:89593
cataract J:89593
disheveled coat J:89593
excessive scratching J:89593
impaired balance J:89593
normal mortality/aging J:89593
postnatal growth retardation J:89593
tremors J:89593
Mapttm1(Setdb1)Akba/Mapt+
Mecp2tm1Jae/Y
Tg(Nes-cre)1Atp/0
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N
impaired coordination J:178512
premature death J:178512
Mapttm1(Setdb1)Akba/Mapttm1(Setdb1)Akba
Mecp2tm1Jae/Y
Tg(Nes-cre)1Atp/0
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N
impaired coordination J:178512
premature death J:178512
Mapttm1.1(FUS)Neas/Mapt+
B6J.129P2(129S)-Mapttm1.1(FUS)Neas
normal nervous system phenotype J:232167
Mapttm1.1(FUS)Neas/Mapttm1.1(FUS)Neas
B6J.129P2(129S)-Mapttm1.1(FUS)Neas
normal nervous system phenotype J:232167
Mapttm1Hnd/Mapt+
Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
involves: 129X1/SvJ * C57BL/6 * DBA/2
abnormal neuron differentiation J:121330
abnormal neuron morphology J:121330
abnormal spatial learning J:121330
amyloid beta deposits J:121330
normal behavior/neurological phenotype J:121330
decreased susceptibility to pharmacologically induced seizures J:121330
Mapttm1Hnd/Mapttm1Hnd
Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
involves: 129X1/SvJ * C57BL/6 * DBA/2
abnormal neuron differentiation J:121330
abnormal neuron morphology J:121330
amyloid beta deposits J:121330
normal behavior/neurological phenotype J:121330
decreased susceptibility to pharmacologically induced seizures J:121330
Mapttm2(Hdac1)Jae/Mapttm2(Hdac1)Jae
involves: 129S4/SvJae * C57BL/6
abnormal hippocampus pyramidal cell morphology J:148391
Mapttm2.1(FUS)Neas/Mapt+
B6J.129P2(129S)-Mapttm2.1(FUS)Neas
abnormal motor neuron innervation pattern J:232167
abnormal neuromuscular synapse morphology J:232167
astrocytosis J:232167
microgliosis J:232167
motor neuron degeneration J:232167
Mapttm2.1(RHOA*)Klt/Mapt+
involves: 129S4/SvJae * C57BL/6 * FVB/N
abnormal somatosensory cortex morphology J:159220
decreased neuron apoptosis J:159220
increased neuron number J:159220
normal nervous system phenotype J:159220
Mapttm2Arbr/Mapt+
Neurod6tm1(cre)Kan/Neurod6+
Trim67tm1.1Slgu/Trim67tm1.1Slgu
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
decreased corpus callosum size J:266702
Mapttm2Arbr/Mapt+
Shox2tm1.1(cre)Oki/Shox2+
Slc17a6tm1.1Thna/Slc17a6tm1.2Edw
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
abnormal nervous system physiology J:209344
Mapttm2Arbr/?
Runx1tm3Spe/Runx1tm1(cre/Esr1*)Ims
involves: 129S4/SvJae * C57BL/6NCrlj * CBA/JNCrlj
abnormal mechanoreceptor morphology J:226826
Mapttm2Arbr/?
Runx1tm3Spe/Runx1tm3Spe
H2az2Tg(Wnt1-cre)11Rth/?
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * CBA/J
abnormal axon morphology J:226826
abnormal sensory neuron innervation pattern J:226826
Mapttm3.1(FUS)Neas/Mapt+
B6J.129P2(129S)-Mapttm3.1(FUS)Neas
abnormal motor neuron innervation pattern J:232167
abnormal neuromuscular synapse morphology J:232167
abnormal sarcomere morphology J:232167
abnormal synaptic bouton morphology J:232167
abnormal synaptic depression J:232167
abnormal synaptic transmission J:232167
abnormal tibialis anterior morphology J:232167
astrocytosis J:232167
microgliosis J:232167
motor neuron degeneration J:232167
paraparesis J:232167
Mapttm3.1(FUS)Neas/Mapttm3.1(FUS)Neas
B6J.129P2(129S)-Mapttm3.1(FUS)Neas
abnormal neuromuscular synapse morphology J:232167
Ppp2r5dtm1Vjan/Ppp2r5dtm1Vjan
Tg(Thy1-MAPT)5Vln/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
abnormal behavior J:171339
decreased thermal nociceptive threshold J:171339
impaired coordination J:171339
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/?
B6.Cg-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa
abnormal behavior J:170670
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
amyloid beta deposits J:107286
neurofibrillary tangles J:107286
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/Tg(APPSwe,tauP301L)1Lfa
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal contextual conditioning behavior J:99604
abnormal learning/memory/conditioning J:99604
amyloid beta deposits J:99604
Tg(APPSWE)2576Kha/0
Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
involves: C57BL/6 * DBA/2 * SJL * SW
abnormal eye physiology J:100965
abnormal neuron morphology J:100965
amyloid beta deposits J:100965
astrocytosis J:100965
decreased grooming behavior J:100965
decreased vocalization J:100965
gliosis J:100965
hunched posture J:100965
neurofibrillary tangles J:100965
neuron degeneration J:100965
paraparesis J:100965
tau protein deposits J:100965
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0
Tg(Prnp-MAPT*P301S)PS19Vle/0
B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas Tg(Prnp-MAPT*P301S)PS19Vle
abnormal dendrite morphology J:211723
abnormal hippocampal mossy fiber morphology J:211723
abnormal hippocampus morphology J:211723
abnormal synapse morphology J:211723
amyloid beta deposits J:211723
astrocytosis J:211723
hippocampal neuron degeneration J:211723
hippocampus atrophy J:211723
loss of hippocampal neurons J:211723
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/0
Tg(Thy1-MAPT*)30Schd/0
involves: C57BL/6 * C57BL/6J * CBA * SJL
abnormal neurite morphology J:201809
amyloid beta deposits J:201809
decreased body weight J:201809
decreased brain weight J:201809
decreased hippocampus pyramidal cell number J:201809
impaired coordination J:201809
neurofibrillary tangles J:201809
premature death J:201809
Tg(APPV717F)109Ili/0
Tg(Prnp-MAPT*P301S)PS19Vle/0
involves: C3H * C57BL/6
amyloid beta deposits J:165441
kyphosis J:165441
neurodegeneration J:165441
neurofibrillary tangles J:165441
paralysis J:165441
paresis J:165441
premature death J:165441
tau protein deposits J:165441
weight loss J:165441
Tg(Camk2a-MAPT)601Ymot/0
involves: C57BL/6 * C57BL/6J
abnormal axon morphology J:172762
abnormal dendritic spine morphology J:172762
abnormal learning/memory/conditioning J:172762
abnormal nucleus accumbens morphology J:172762
abnormal spatial working memory J:172762
abnormal synapse morphology J:172762
decreased anxiety-related response J:172762
decreased cellular glucose uptake J:172762
impaired spatial learning J:172762
Tg(Camk2a-MAPT*P301L)D35Jiri/0
Not Specified
neurofibrillary tangles J:222897
Tg(Camk2a-MAPT*R406W)748Atak/0
involves: C57BL/6 * SJL
abnormal contextual conditioning behavior J:100958
abnormal cued conditioning behavior J:100958
decreased prepulse inhibition J:100958
premature death J:100958
tau protein deposits J:100958
Tg(Camk2a-tTA)1Mmay/0
Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
involves: 129/Sv * C57BL/6 * CBA * FVB/N
abnormal dentate gyrus morphology J:185792
hippocampal neuron degeneration J:185792
Tg(Camk2a-tTA)1Mmay/?
Fgf14Tg(tetO-MAPT*P301L)4510Kha/?
involves: 129S6/SvEvTac * FVB/N
abnormal hippocampus CA1 region morphology J:99626
abnormal neuron morphology J:99626
abnormal spatial learning J:99626
decreased brain weight J:99626
decreased hippocampus pyramidal cell number J:99626
forebrain atrophy J:99626
neurofibrillary tangles J:99626
Tg(Camk2a-tTA)1Mmay/0
Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
involves: 129S6/SvEvTac * FVB/N
abnormal anxiety-related response J:207366
decreased anxiety-related response J:207366
hyperactivity J:207366
impaired contextual conditioning behavior J:207366
impaired cued conditioning behavior J:207366
increased anxiety-related response J:207366
increased exploration in new environment J:207366
neurofibrillary tangles J:207366
tau protein deposits J:207366
Tg(Camk2a-tTA)1Mmay/0
Fgf14Tg(tetO-MAPT*P301L)4510Kha/Fgf14+
involves: FVB/N
abnormal corticospinal tract morphology J:102973
abnormal gait J:102973
abnormal spatial reference memory J:102973
abnormal spinal cord morphology J:102973
astrocytosis J:102973
decreased brain weight J:102973
decreased exploration in new environment J:102973
dystonia J:102973
forebrain atrophy J:102973
hippocampal neuron degeneration J:102973
hunched posture J:102973
impaired coordination J:102973
impaired swimming J:102973
limb grasping J:102973
neurofibrillary tangles J:102973
neuron degeneration J:102973
tau protein deposits J:102973
weight loss J:102973
Tg(Camk2a-tTA)1Mmay/0
Tg(PDGFB-APPSwInd)J9Lms/0
Tg(tetO-MAPT*A152T)L1Lms/0
involves: C57BL/6 * C57BL/6J * DBA/2
abnormal brain wave pattern J:233816
lethality, incomplete penetrance J:233816
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-MAPT)32Lms/0
B6.Cg-Tg(Camk2a-tTA)1Mmay Tg(tetO-MAPT)32Lms
abnormal brain morphology J:233816
abnormal brain wave pattern J:233816
abnormal CNS synaptic transmission J:233816
decreased body weight J:233816
decreased paired-pulse facilitation J:233816
increased susceptibility to pharmacologically induced seizures J:233816
normal mortality/aging J:233816
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-MAPT*A152T)L1Lms/0
B6.Cg-Tg(Camk2a-tTA)1Mmay Tg(tetO-MAPT*A152T)L1Lms
abnormal brain morphology J:233816
abnormal brain wave pattern J:233816
abnormal CNS synaptic transmission J:233816
abnormal nest building behavior J:233816
astrocytosis J:233816
decreased body weight J:233816
decreased paired-pulse facilitation J:233816
hippocampal neuron degeneration J:233816
impaired spatial learning J:233816
increased susceptibility to pharmacologically induced seizures J:233816
normal mortality/aging J:233816
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-MAPT*K280,-luc)#Eman/0
involves: C57BL/6
abnormal neurite morphology J:131379
abnormal synapse morphology J:131379, J:169532
astrocytosis J:131379, J:169532
decreased post-tetanic potentiation J:169532
impaired coordination J:169532
impaired passive avoidance behavior J:169532
impaired spatial learning J:169532
impaired synaptic plasticity J:169532
neurofibrillary tangles J:131379, J:169532
neuron degeneration J:131379, J:169532
reduced long term potentiation J:169532
tau protein deposits J:131379, J:169532
Tg(Camk2a-tTA)1Mmay/0
Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Tg(tetO-MAPT)32Lms/0
involves: C57BL/6 * C57BL/6J * DBA/2
lethality, incomplete penetrance J:233816
premature death J:233816
Tg(Camk2a-tTA)1Mmay/0
Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
Tg(tetO-MAPT*A152T)L1Lms/0
involves: C57BL/6 * C57BL/6J * DBA/2
lethality at weaning J:233816
preweaning lethality, incomplete penetrance J:233816
Tg(GSK3B*S9A)1Vln/0
Tg(Thy1-MAPT)1Vln/Tg(Thy1-MAPT)1Vln
involves: FVB
abnormal axon morphology J:100971
normal behavior/neurological phenotype J:100971
impaired coordination J:100971
normal muscle phenotype J:100971
Tg(GSK3B*S9A)1Vln/0
Tg(Thy1-MAPT)2Vln/Tg(Thy1-MAPT)2Vln
involves: FVB
abnormal axon morphology J:100971
normal behavior/neurological phenotype J:100971
impaired coordination J:100971
normal muscle phenotype J:100971
Tg(Hmgcr-MAPT)23Brio/0
involves: C57BL/6J * CBA
normal nervous system phenotype J:101993
Tg(MAPT*V337M)1Gds/0
B6J.Cg-Tg(MAPT*V337M)1Gds
abnormal CNS synaptic transmission J:218742
abnormal excitatory postsynaptic currents J:218742
abnormal excitatory postsynaptic potential J:218742
abnormal miniature excitatory postsynaptic currents J:218742
abnormal nest building behavior J:218742
abnormal postsynaptic density morphology J:218742
decreased anxiety-related response J:218742
increased grooming behavior J:218742
Tg(Mapt-MAPT*)#Hanr/0
involves: BALB/c * C57BL/6
abnormal brain morphology J:137947
abnormal long term potentiation J:137947
abnormal long term spatial reference memory J:137947
abnormal spatial learning J:137947
astrocytosis J:137947
normal behavior/neurological phenotype J:137947
decreased paired-pulse facilitation J:137947
increased anxiety-related response J:137947
neurofibrillary tangles J:137947
tau protein deposits J:137947
Tg(PDGFB-MAPT*V337M)1Atak/0
involves: C57BL/6 * SJL
abnormal nervous system electrophysiology J:100964
abnormal neuron morphology J:100964
hippocampal neuron degeneration J:100964
loss of hippocampal neurons J:100964
tau protein deposits J:100964
Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi
Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
involves: C3HeB/FeJ * C57BL/6
abnormal gait J:197198
abnormal grooming behavior J:197198
abnormal synapse morphology J:197198
amyloid beta deposits J:197198
hunched posture J:197198
increased inflammatory response J:197198
limb grasping J:197198
neurofibrillary tangles J:197198
premature death J:197198
tau protein deposits J:197198
weight loss J:197198
Tg(Prnp-ITM2B*)7Jckr/0
Tg(Thy1-MAPT*P301S)2541Godt/0
B6.Cg-Tg(Prnp-ITM2B*)7Jckr Tg(Thy1-MAPT*P301S)2541Godt
neurofibrillary tangles J:159279
tau protein deposits J:159279
Tg(Prnp-MAPT)4Hlmc/0
involves: C57BL/6 * DBA/2
normal behavior/neurological phenotype J:63887
Tg(Prnp-MAPT)7Vle/0
involves: C57BL/6 * SJL
abnormal axon morphology J:61052
abnormal axonal transport J:61052
abnormal motor neuron morphology J:61052
astrocytosis J:61052
axon degeneration J:61052
decreased body weight J:61052
impaired balance J:61052
limb grasping J:61052
motor neuron degeneration J:61052
neurofibrillary tangles J:61052
tau protein deposits J:61052
weakness J:61052
Tg(Prnp-MAPT)25Hlmc/0
involves: C57BL/6 * DBA/2
abnormal brain morphology J:63887
normal behavior/neurological phenotype J:63887
Tg(Prnp-MAPT)43Vle/0
involves: C57BL/6 * DBA/2
abnormal axon morphology J:61052
abnormal axonal transport J:61052
abnormal motor neuron morphology J:61052
astrocytosis J:61052
axon degeneration J:61052
decreased body weight J:61052
impaired balance J:61052
limb grasping J:61052
motor neuron degeneration J:61052
tau protein deposits J:61052
Tg(Prnp-MAPT)43Vle/Tg(Prnp-MAPT)43Vle
involves: C57BL/6 * DBA/2
normal mortality/aging J:61052
premature death J:61052
Tg(Prnp-MAPT)#Lgn/0
involves: C57BL/6 * FVB/N
astrocytosis J:230252
Tg(Prnp-MAPT*)2652Gds/0
B6.Cg-Tg(Prnp-MAPT*)2652Gds
abnormal behavior J:244052
abnormal neurite morphology J:244052
abnormal spatial reference memory J:244052
axonal spheroids J:244052
decreased body weight J:244052
decreased grip strength J:244052
decreased vertical activity J:244052
hypoactivity J:244052
impaired coordination J:244052
skeletal muscle fiber atrophy J:244052
tau protein deposits J:244052
Tg(Prnp-MAPT*)2652Gds/Tg(Prnp-MAPT*)2652Gds
B6.Cg-Tg(Prnp-MAPT*)2652Gds
abnormal locomotor behavior J:244052
decreased body weight J:244052
premature death J:244052
reduced fertility J:244052
seizures J:244052
Tg(Prnp-MAPT*K274Q*K281Q)1Lgn/0
involves: C57BL/6 * FVB/N
astrocytosis J:230252
impaired synaptic plasticity J:230252
reduced long term potentiation J:230252
tau protein deposits J:230252
Tg(Prnp-MAPT*K274Q*K281Q)286Lgn/0
involves: C57BL/6 * FVB/N
abnormal dentate gyrus morphology J:230252
abnormal excitatory postsynaptic potential J:230252
abnormal long term spatial reference memory J:230252
astrocytosis J:230252
impaired contextual conditioning behavior J:230252
impaired discrimination learning J:230252
impaired synaptic plasticity J:230252
reduced long term potentiation J:230252
tau protein deposits J:230252
Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
involves: C3HeB/FeJ * C57BL/6
abnormal grooming behavior J:197198
abnormal synapse morphology J:197198
dystonia J:197198
hunched posture J:197198
limb grasping J:197198
neurodegeneration J:197198
premature death J:197198
tau protein deposits J:197198
weight loss J:197198
Tg(Prnp-MAPT*P301L)JNPL3Hlmc/?
involves: C57BL/6 * DBA/2
abnormal cranial nerve morphology J:63887
abnormal locomotor behavior J:63887
abnormal posture J:63887
abnormal sarcomere morphology J:63887
abnormal skeletal muscle fiber morphology J:63887
cachexia J:63887
decreased grip strength J:63887
decreased grooming behavior J:63887
decreased motor neuron number J:63887
decreased vocalization J:63887
eye inflammation J:63887
gliosis J:63887
limb grasping J:63887
neurofibrillary tangles J:63887
premature death J:63887
weakness J:63887
weight loss J:63887
Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
involves: C57BL/6 * DBA/2 * SJL * SW
abnormal eye physiology J:100965
abnormal neuron morphology J:100965
decreased grooming behavior J:100965
decreased vocalization J:100965
gliosis J:100965
hunched posture J:100965
neurofibrillary tangles J:100965
neuron degeneration J:100965
paraparesis J:100965
tau protein deposits J:100965
Tg(Prnp-MAPT*P301L)JNPL3Hlmc/0
involves: C57BL/6JJcl * DBA/2 * SW
abnormal spinal cord morphology J:100900
tau protein deposits J:100900
Tg(Prnp-MAPT*P301S)50Hiw/0
B6.Cg-Tg(Prnp-MAPT*P301S)50Hiw
abnormal axonal transport J:213361
abnormal cell physiology J:213361
abnormal motor capabilities/coordination/movement J:213361
abnormal response to novel object J:213361
abnormal spatial working memory J:213361
decreased body weight J:213361
limb grasping J:213361
premature death J:213361
tau protein deposits J:213361
Tg(Prnp-MAPT*P301S)PS19Vle/0
B6.Cg-Tg(Prnp-MAPT*P301S)PS19Vle
abnormal behavior J:174441
abnormal contextual conditioning behavior J:174441
abnormal emotion/affect behavior J:174441
abnormal social investigation J:174441
decreased anxiety-related response J:174441
decreased thermal nociceptive threshold J:174441
hyperactivity J:174441
increased prepulse inhibition J:174441
increased vertical activity J:174441
tau protein deposits J:174441
Tg(Prnp-MAPT*P301S)PS19Vle/0
involves: C3H * C57BL/6
abnormal amygdala morphology J:119741
abnormal cerebral cortex morphology J:119741
abnormal CNS synaptic transmission J:119741
abnormal dentate gyrus morphology J:119741
abnormal entorhinal cortex morphology J:119741
abnormal excitatory postsynaptic potential J:119741
abnormal hippocampal mossy fiber morphology J:119741
abnormal hippocampus pyramidal cell morphology J:119741
abnormal spatial learning J:174441
abnormal spinal cord white matter morphology J:119741
astrocytosis J:119741
brain atrophy J:119741
decreased hippocampus volume J:119741
decreased paired-pulse facilitation J:119741
dilated brain ventricles J:119741
dystrophic muscle J:119741
hippocampal neuron degeneration J:119741
hippocampus atrophy J:119741
hunched posture J:119741, J:165441
limb grasping J:119741
loss of hippocampal neurons J:119741
neurodegeneration J:119741
neurofibrillary tangles J:119741, J:165441
paralysis J:119741, J:165441
paresis J:165441
premature death J:119741, J:165441
progressive muscle weakness J:119741
reduced long term potentiation J:119741
tau protein deposits J:119741, J:165441, J:233816
weakness J:119741
weight loss J:165441
Tg(Prnp-MAPT*P301S)PS19Vle/Tg(Prnp-MAPT*P301S)PS19Vle
involves: C3H * C57BL/6
abnormal sexual interaction J:119741
Tg(Prnp-MAPT*R406W)21807Dwst/?
FVB/N-Tg(Prnp-MAPT*R406W)21807Dwst
abnormal avoidance learning behavior J:95971
astrocytosis J:95971
impaired coordination J:95971
microgliosis J:95971
normal muscle phenotype J:95971
neurofibrillary tangles J:95971
tau protein deposits J:95971
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Tg(Thy1-MAPT*P301S)2541Godt/0
B6.Cg-Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr Tg(Thy1-MAPT*P301S)2541Godt
tau protein deposits J:159279
Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz/0
Tg(Thy1-MAPT)183Gotz/0
B6.Cg-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz Tg(Thy1-MAPT)183Gotz
abnormal spatial learning J:154968
amyloid beta deposits J:154968
hyperactivity J:154968
tau protein deposits J:154968
Tg(Thy1-MAPT)1Vln/0
FVB/N-Tg(Thy1-MAPT)1Vln
abnormal axon morphology J:96869
abnormal motor coordination/balance J:96869
axon degeneration J:96869
limb grasping J:96869
muscular atrophy J:96869
Tg(Thy1-MAPT)1Vln/0
involves: FVB
abnormal axon morphology J:100972
abnormal locomotor activation J:100972
impaired coordination J:100972
Tg(Thy1-MAPT)1Vln/Tg(Thy1-MAPT)1Vln
involves: FVB
abnormal axon morphology J:100971, J:100972
abnormal cell cytoskeleton morphology J:100971
abnormal locomotor activation J:100972
abnormal neuron morphology J:100972
abnormal postural reflex J:100972
astrocytosis J:100972
axon degeneration J:100972
decreased body weight J:100972
decreased skeletal muscle mass J:100972
impaired coordination J:100971, J:100972
impaired righting response J:100971
limb grasping J:100972
muscle weakness J:100972
muscular atrophy J:100971, J:100972
normal nervous system phenotype J:100972
skeletal muscle fiber atrophy J:100972
tau protein deposits J:100972
Tg(Thy1-MAPT)2Vln/Tg(Thy1-MAPT)2Vln
involves: FVB
abnormal axon morphology J:100971
abnormal cell cytoskeleton morphology J:100971
impaired coordination J:100971, J:100972
impaired righting response J:100971
limb grasping J:100972
muscular atrophy J:100971
Tg(Thy1-MAPT)5Vln/Tg(Thy1-MAPT)5Vln
involves: FVB
abnormal axon morphology J:100972
impaired coordination J:100972
Tg(Thy1-MAPT)22Schd/0
B6.Cg-Tg(Thy1-MAPT)22Schd
abnormal axon morphology J:111982
abnormal brain morphology J:111982
abnormal CNS synaptic transmission J:111982
abnormal hippocampus morphology J:111982
abnormal neuron morphology J:111982
abnormal spatial learning J:111982
normal behavior/neurological phenotype J:111982
decreased anxiety-related response J:111982
decreased body weight J:111982
decreased excitatory postsynaptic current amplitude J:111982
gliosis J:111982
normal nervous system phenotype J:111982
neurofibrillary tangles J:111982
premature death J:111982
tau protein deposits J:111982
Tg(Thy1-MAPT)22Schd/0
involves: C57BL/6 * CBA
abnormal locomotor circadian rhythm J:197067
abnormal response to new environment J:197067
anhedonia J:197067
behavioral despair J:197067
decreased serotonin level J:197067
hyperactivity J:197067
increased aggression towards mice J:197067
Tg(Thy1-MAPT)183Gotz/0
B6.Cg-Tg(Thy1-MAPT)183Gotz
abnormal spatial learning J:154968
enhanced coordination J:154968
tau protein deposits J:154968
Tg(Thy1-MAPT*)1Avil/0
involves: C57BL/6 * CBA
abnormal dentate gyrus morphology J:182782
abnormal hippocampus granule cell layer J:182782
abnormal innervation J:182782
abnormal neuron morphology J:73872
behavioral despair J:182782
hippocampal neuron degeneration J:182782
Tg(Thy1-MAPT*)1Avil/Tg(Thy1-MAPT*)1Avil
involves: C57BL/6 * CBA
astrocytosis J:201700
gliosis J:201700
increased susceptibility to pharmacologically induced seizures J:201700
microgliosis J:201700
myoclonus J:201700
nonconvulsive seizures J:201700
seizures J:201700
tau protein deposits J:201700
tonic-clonic seizures J:201700
Tg(Thy1-MAPT*)30Schd/0
involves: C57BL/6 * C57BL/6J * CBA * SJL
impaired coordination J:201809
neurofibrillary tangles J:201809
Tg(Thy1-MAPT*)30Schd/0
involves: C57BL/6 * CBA
abnormal brain morphology J:169074
abnormal posture J:111982
abnormal sciatic nerve morphology J:169074
abnormal spinal cord morphology J:169074
normal behavior/neurological phenotype J:169074
hindlimb paralysis J:111982
impaired coordination J:169074
neurofibrillary tangles J:169074
premature death J:169074
Tg(Thy1-MAPT*K369I)K3Gotz/0
B6.Cg-Tg(Thy1-MAPT*K369I)K3Gotz
abnormal axon morphology J:143439
abnormal axonal transport J:143439
abnormal gait J:143439
abnormal motor capabilities/coordination/movement J:143439
abnormal neuron morphology J:143439
abnormal object recognition memory J:143439
bradykinesia J:143439
decreased body weight J:143439
decreased dopamine level J:143439
enhanced behavioral response to xenobiotic J:143439
impaired coordination J:143439
limb grasping J:143439
loss of dopaminergic neurons J:143439
muscular atrophy J:143439
normal nervous system phenotype J:143439
short stride length J:143439
tremors J:143439
Tg(Thy1-MAPT*L266V*G272V)13Ema/0
involves: C57BL/6 * DBA/2
abnormal dendrite morphology J:229181
abnormal dentate gyrus morphology J:229181
abnormal habituation to a new environment J:229181
abnormal spatial reference memory J:229181
axonal dystrophy J:229181
decreased neocortex volume J:229181
decreased neuron number J:229181
hyperactivity J:229181
impaired coordination J:229181
impaired spatial learning J:229181
increased thigmotaxis J:229181
increased vertical activity J:229181
neurodegeneration J:229181
neuronal intranuclear inclusions J:229181
tau protein deposits J:229181
Tg(Thy1-MAPT*P301L)2Vln/Tg(Thy1-MAPT*P301L)2Vln
FVB/N-Tg(Thy1-MAPT*P301L)2Vln
abnormal motor coordination/balance J:96869
hindlimb paralysis J:96869
limb grasping J:96869
normal nervous system phenotype J:96869
neurofibrillary tangles J:96869
paralysis J:96869
premature death J:96869
tau protein deposits J:96869
weight loss J:96869
Tg(Thy1-MAPT*P301S)2541Godt/Tg(Thy1-MAPT*P301S)2541Godt
involves: C57BL/6J * CBA/Ca
abnormal glial cell morphology J:108870
astrocytosis J:108870
decreased motor neuron number J:108870
eye inflammation J:108870
limb grasping J:108870
muscle weakness J:108870
neurodegeneration J:108870
paraparesis J:108870
skeletal muscle fiber atrophy J:108870
tau protein deposits J:108870
tremors J:108870
Tg(Thy1-MAPT*V337M)1Godt/0
involves: C57BL/6J * CBA/Ca
abnormal impulsive behavior control J:143018
normal behavior/neurological phenotype J:143018
Tg(Tuba1-MAPT)14Vle/0
involves: C57BL/6 * SJL
abnormal astrocyte morphology J:78400
abnormal myelin sheath morphology J:78400
abnormal Schwann cell morphology J:78400
axon degeneration J:78400
decreased neuron number J:78400
decreased oligodendrocyte number J:78400
dystonia J:78400
jerky movement J:78400
tau protein deposits J:78400
weakness J:78400

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory