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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Mapt
microtubule-associated protein tau
MGI:97180
40 phenotypes from 16 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Chattm2(cre)Lowl/Chat+
Mapttm3(Sema3e)Arbr/Mapttm3(Sema3e)Arbr
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
abnormal motor neuron innervation pattern J:149553
normal behavior/neurological phenotype J:149553
Isl1tm1(cre)Tmj/Isl1+
Mapttm1(Ewsr1/Etv4)Arbr/Mapt+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal dorsal root ganglion morphology J:100886
abnormal sensory neuron innervation pattern J:100886
abnormal sensory neuron morphology J:100886
decreased muscle spindle number J:100886
Kansl1/Mapttm1.1Cole/Kansl1/Mapttm1.1Cole
involves: C57BL/6 * C57BL/6J * C57BL/6JOlaHsd
abnormal axonal transport J:188213
normal behavior/neurological phenotype J:188213
hyperactivity J:188213
normal nervous system phenotype J:188213
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
B6.129S4-Mapttm1(EGFP)Klt
abnormal motor learning J:213115
enhanced spatial learning J:213115
impaired contextual conditioning behavior J:213115
impaired cued conditioning behavior J:213115
reduced long term potentiation J:213115
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
involves: 129S4/SvJae * C57BL/6
normal behavior/neurological phenotype J:169074
no abnormal phenotype detected J:66561
Mapttm1(Ewsr1/Etv4)Arbr/Mapt+
Mnx1tm4(cre)Tmj/Mnx1+
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
abnormal axon extension J:100886
Mapttm1(MAPT)Vln/Mapttm1(MAPT)Vln
FVB.Cg-Mapttm1(MAPT)Vln
abnormal motor coordination/balance J:96869
normal nervous system phenotype J:96869
Mapttm1(MAPT)Vln/Mapttm1(MAPT)Vln
involves: FVB/N
abnormal axon extension J:129032
abnormal dendrite morphology J:129032
abnormal hippocampus pyramidal cell morphology J:129032
abnormal long term object recognition memory J:129032
decreased anxiety-related response J:129032
enlarged hippocampus J:129032
increased cell proliferation J:129032
Mapttm1(Sema3e)Yuyo/Mapt+
Olig2tm1(cre)Tmj/Olig2+
Not Specified
abnormal excitatory postsynaptic potential J:205528
abnormal sensory neuron innervation pattern J:205528
abnormal synaptic bouton morphology J:205528
normal nervous system phenotype J:205528
Mapttm1(Setdb1)Akba/Mapttm1(Setdb1)Akba
involves: 129S7/SvEvBrd * C57BL/6J
normal behavior/neurological phenotype J:178512
normal mortality/aging J:178512
Mapttm1.1Cole/Mapttm1.1Cole
involves: C57BL/6J * C57BL/6JOlaHsd
normal behavior/neurological phenotype J:188213
Mapttm1Aha/Mapttm1Aha
Not Specified
abnormal axon morphology J:123734
Mapttm1b(EUCOMM)Hmgu/Mapttm1b(EUCOMM)Hmgu
C57BL/6N-Mapttm1b(EUCOMM)Hmgu/Ics
abnormal behavior J:211773
abnormal retinal blood vessel morphology J:211773
abnormal retinal vasculature morphology J:211773
decreased grip strength J:211773
decreased total retina thickness J:211773
increased lean body mass J:211773
persistence of hyaloid vascular system J:211773
polycystic kidney J:211773
Mapttm1Hnd/Mapt+
involves: 129X1/SvJ * C57BL/6
decreased susceptibility to pharmacologically induced seizures J:121330
Mapttm1Hnd/Mapttm1Hnd
involves: 129X1/SvJ * C57BL/6
abnormal axon extension J:78649
abnormal dendrite morphology J:78649
decreased susceptibility to pharmacologically induced seizures J:121330
Mapttm1Noh/Mapttm1Noh
involves: 129S4/SvJae
abnormal axon morphology J:19030
Mapttm2(cre)Aha/Mapttm2(cre)Aha
Not Specified
normal nervous system phenotype J:134499
Mapttm2Arbr/Mapt+
Pvalbtm1(cre)Arbr/Pvalb+
involves: 129P2/OlaHsd * C57BL/6
abnormal dorsal root ganglion morphology J:100886
Mapttm3(cre/PGR)Aha/Mapttm3(cre/PGR)Aha
Not Specified
no abnormal phenotype detected J:136624
Mapttm3(Hdac2)Jae/Mapttm3(Hdac2)Jae
involves: 129S4/SvJae * C57BL/6
abnormal dentate gyrus morphology J:148391
abnormal hippocampus CA1 region morphology J:148391
abnormal hippocampus pyramidal cell morphology J:148391
abnormal spatial learning J:148391
abnormal spatial working memory J:148391
impaired contextual conditioning behavior J:148391
reduced long term potentiation J:148391

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory