Mpl Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mpl
myeloproliferative leukemia virus oncogene
MGI:97076

26 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Babam1^{Gt(IST11207B9)Tigm}/Babam1^{Gt(IST11207B9)Tigm} Mpl^tm1Mwm/Mpl^tm1Mwm involves: 129S2/SvPas * C57BL/6N	decreased hematopoietic stem cell number	J:223526
	thrombocytopenia	J:223526
Ep300^Plt6/Ep300⁺ Mpl^tm1Wsa/Mpl^tm1Wsa involves: 129S1/Sv * C57BL/6	abnormal megakaryocyte progenitor cell morphology	J:140200
	abnormal platelet morphology	J:140200
	increased eosinophil cell number	J:140200
	increased megakaryocyte cell number	J:140200
Ep300^Plt6/Ep300^Plt6 Mpl^tm1Wsa/Mpl^tm1Wsa involves: 129S1/Sv * C57BL/6	abnormal megakaryocyte progenitor cell morphology	J:140200
	increased megakaryocyte cell number	J:140200
	postnatal lethality	J:140200
	thrombocytosis	J:140200
Erg^mld2/Erg⁺ Mpl^tm1Wsa/Mpl^tm1Wsa B6.Cg-Mpl^tm1Wsa Erg^mld2	anemia	J:137835
	decreased leukocyte cell number	J:137835
	thrombocytopenia	J:137835
Fli1^tm1Dkw/Fli1⁺ Mpl^tm1Wsa/Mpl^tm1Wsa involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6	normal hematopoietic system phenotype	J:137835
	thrombocytopenia	J:137835
Lyn^mld4/Lyn^mld4 Mpl^tm1Wsa/Mpl^tm1Wsa B6.129S1-Mpl^tm1Wsa	decreased erythrocyte cell number	J:144799
	decreased leukocyte cell number	J:144799
	thrombocytopenia	J:144799
Mpl^tm1Wsa/Mpl^tm1Wsa Myb^Plt3/Myb⁺ involves: 129S1/Sv * C57BL/6	abnormal definitive hematopoiesis	J:89601
	abnormal megakaryocyte differentiation	J:89601
	abnormal thrombopoiesis	J:89601
	thrombocytosis	J:89601
Mpl^tm1Wsa/Mpl^tm1Wsa Myb^Plt3/Myb^Plt3 involves: 129S1/Sv * C57BL/6	abnormal B cell differentiation	J:89601
	abnormal definitive hematopoiesis	J:89601
	abnormal erythropoiesis	J:89601
	abnormal megakaryocyte differentiation	J:89601
	abnormal spleen morphology	J:89601
	abnormal thrombopoiesis	J:89601
	anemia	J:89601
	decreased spleen B cell follicle size	J:89601
	increased spleen red pulp amount	J:89601
	perinatal lethality, incomplete penetrance	J:89601
	thrombocytosis	J:89601
Mpl^tm1Wsa/Mpl^tm1Wsa Myb^Plt4/Myb⁺ involves: 129S1/Sv * C57BL/6	abnormal definitive hematopoiesis	J:89601
	abnormal megakaryocyte differentiation	J:89601
	abnormal thrombopoiesis	J:89601
	thrombocytosis	J:89601
Mpl^tm1Wsa/Mpl^tm1Wsa Myb^Plt4/Myb^Plt4 involves: 129S1/Sv * C57BL/6	abnormal definitive hematopoiesis	J:89601
	abnormal erythropoiesis	J:89601
	abnormal megakaryocyte differentiation	J:89601
	abnormal spleen morphology	J:89601
	abnormal thrombopoiesis	J:89601
	anemia	J:89601
	decreased leukocyte cell number	J:89601
	decreased spleen B cell follicle size	J:89601
	increased spleen red pulp amount	J:89601
	thrombocytosis	J:89601
Mpl^tm1Wsa/Mpl^tm1Wsa Suz12^{Gt(Betageo)1Khe}/Suz12⁺ involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	abnormal thrombopoiesis	J:136262
	increased leukocyte cell number	J:136262
	increased lymphocyte cell number	J:136262
	thrombocytopenia	J:136262
Mpl^tm1Wsa/Mpl^tm1Wsa Suz12^Plt8/Suz12⁺ B6.Cg-Mpl^tm1Wsa Suz12^Plt8	abnormal bone marrow cell morphology/development	J:136262
	abnormal megakaryocyte differentiation	J:136262
	abnormal thrombopoiesis	J:136262
	increased leukocyte cell number	J:136262
	increased lymphocyte cell number	J:136262
	thrombocytopenia	J:136262
Mpl^tm1Wsa/Mpl^tm1Wsa Suz12^Plt8/Suz12^Plt8 B6.Cg-Mpl^tm1Wsa Suz12^Plt8	decreased embryo size	J:136262
	prenatal lethality, complete penetrance	J:136262

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