Ascl2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ascl2
achaete-scute family bHLH transcription factor 2
MGI:96920

16 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ascl2^tm1.1Cle/Ascl2^tm1.1Cle Tg(Cyp1a1-cre)1Dwi/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal small intestine crypts of Lieberkuhn morphology	J:148715
	increased small intestinal crypt cell apoptosis	J:148715
Ascl2^tm1.1Nagy/Ascl2⁺ involves: 129S1/Sv * 129X1/SvJ * CD-1	decreased spongiotrophoblast cell number	J:57828
Ascl2^tm1Alj/Ascl2⁺ involves: 129 * CD-1	abnormal chorion morphology	J:23260
	abnormal spongiotrophoblast layer morphology	J:23260
	paternal imprinting	J:23260
	postnatal lethality, complete penetrance	J:23260
Ascl2^tm1Alj/Ascl2^tm1Alj either: (involves: 129) or (involves: 129 * CD-1)	abnormal chorion morphology	J:20553
	abnormal placenta development	J:20553
	abnormal placental labyrinth vasculature morphology	J:20553
	absent spongiotrophoblast	J:20553
	embryonic lethality during organogenesis, complete penetrance	J:20553
Ascl2^tm1Alj/Ascl2^tm1Alj involves: 129 * CD-1	abnormal chorion morphology	J:23260
	absent spongiotrophoblast	J:23260
	embryonic lethality during organogenesis, complete penetrance	J:23260
Ascl2^tm2Nagy/Ascl2^tm2Nagy involves: 129S1/Sv * 129X1/SvJ * Hsd:ICR	no abnormal phenotype detected	J:153719
Tg(Vil1-Ascl2)1Cle/? involves: C57BL/6 * CBA	abnormal ileum crypts of Lieberkuhn morphology	J:148715
	abnormal small intestinal villus morphology	J:148715
	branched small intestinal villi	J:148715
	decreased small intestinal villus height	J:148715

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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