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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lrp1
low density lipoprotein receptor-related protein 1
MGI:96828
34 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Apoetm1Lmh/Apoetm1Lmh
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		atherosclerotic lesions J:129557
increased susceptibility to atherosclerosis J:129557
Apoetm1Lmh/Apoetm1Lmh
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Tg(Mx1-cre)29-4Her/0
involves: 129S7/SvEvBrd * C57BL/6J * SJL 		abnormal circulating enzyme level J:90547
abnormal circulating protein level J:90547
decreased circulating cholesterol level J:90547
decreased circulating LDL cholesterol level J:90547
decreased circulating triglyceride level J:90547
decreased circulating VLDL cholesterol level J:90547
increased circulating cholesterol level J:117317
increased circulating factor VIII level J:90547, J:117317
increased circulating HDL cholesterol level J:117317
increased circulating LDL cholesterol level J:117317
increased circulating triglyceride level J:117317
increased circulating von Willebrand factor level J:90547
increased susceptibility to atherosclerosis J:90547
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
involves: 129S7/SvEvBrd 		abnormal cholesterol level J:67929
abnormal circulating apolipoprotein E level J:67929
abnormal circulating apolipoprotein level J:67929
increased circulating cholesterol level J:67929
increased circulating LDL cholesterol level J:67929
increased circulating triglyceride level J:67929
increased circulating VLDL cholesterol level J:67929
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		impaired macrophage phagocytosis J:137404
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J 		abnormal microglial cell physiology J:144185
abnormal response to CNS ischemic injury J:144185
decreased cerebral infarct size J:144185
decreased susceptibility to ischemic brain injury J:144185
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Tg(Mx1-cre)29-4Her/0
involves: 129S7/SvEvBrd * C57BL/6 * SJL 		increased circulating cholesterol level J:117317
increased circulating factor VIII level J:117317
increased circulating triglyceride level J:117317
increased circulating von Willebrand factor level J:117317
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Tg(Mx1-cre)29-4Her/0
involves: 129S7/SvEvBrd * C57BL/6J * SJL 		abnormal circulating apolipoprotein level J:67929
increased circulating cholesterol level J:67929
increased circulating LDL cholesterol level J:67929
increased circulating triglyceride level J:67929
increased circulating VLDL cholesterol level J:67929
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Tg(Tagln-cre)1Her/0
involves: 129S7/SvEvBrd * C57BL/6J * SJL 		abdominal aorta aneurysm J:82871
abnormal aorta elastic tissue morphology J:82871
aortic aneurysm J:82871
artery occlusion J:82871
atherosclerotic lesions J:82871
dilated aorta J:82871
normal homeostasis/metabolism phenotype J:82871
increased aorta wall thickness J:82871
increased susceptibility to atherosclerosis J:82871
increased vascular smooth muscle cell proliferation J:82871
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Vldlrtm1Her/Vldlrtm1Her
Tg(Mx1-cre)29-4Her/0
involves: 129S7/SvEvBrd * C57BL/6 * SJL 		increased circulating factor VIII level J:117317
Lrp1tm2Her/Lrp1tm2Her
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
Tg(Tagln-cre)1Her/0
involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * C57BL/6J * SJL 		amyloid beta deposits J:192453
astrocytosis J:192453
cerebral amyloid angiopathy J:192453
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory