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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Lif
leukemia inhibitory factor
MGI:96787
68 phenotypes from 3 alleles in 9 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Liftm1Cgre/Liftm1Cgre
involves: MF1
abnormal macrophage morphology J:96965
abnormal uterus morphology J:96965
increased eosinophil cell number J:96965
increased uterine NK cell number J:96965
Liftm1Phb/Lif+
involves: 129S2/SvPas * C57BL/6 * DBA/2
decreased body size J:77410
decreased erythroid progenitor cell number J:77410
decreased hematopoietic stem cell number J:77410
decreased T cell proliferation J:77410
Liftm1Phb/Liftm1Phb
involves: 129S2/SvPas * C57BL/6 * DBA/2
abnormal embryo apposition J:63668
abnormal embryo attachment J:63668
abnormal uterine receptivity J:63668
decreased body size J:77410
decreased common myeloid progenitor cell number J:77410
decreased erythroid progenitor cell number J:77410
decreased hematopoietic stem cell number J:77410
decreased T cell proliferation J:77410
failure of embryo implantation J:63668
female infertility J:63668, J:77410
normal hematopoietic system phenotype J:77410
Liftm1Stw/Liftm1Stw
involves: 129S1/Sv
abnormal involution of the mammary gland J:83804
abnormal mammary gland alveolus morphology J:83804
abnormal mammary gland duct morphology J:83804
abnormal mammary gland growth during pregnancy J:83804
abnormal mammary gland physiology J:83804
decreased circulating adrenocorticotropin level J:34269
decreased motor neuron number J:103711
Liftm1Stw/Liftm1Stw
involves: 129S1/Sv * BALB/c
abnormal hepatocyte morphology J:136940
abnormal pilomotor reflex J:136940
decreased interleukin-10 secretion J:136940
decreased leukocyte cell number J:136940
diarrhea J:136940
hepatic necrosis J:136940
increased circulating alanine transaminase level J:136940
increased circulating aspartate transaminase level J:136940
increased circulating interleukin-6 level J:136940
increased circulating serum amyloid protein level J:136940
increased circulating tumor necrosis factor level J:136940
increased susceptibility to bacterial infection induced morbidity/mortality J:136940
increased susceptibility to endotoxin shock J:136940
increased susceptibility to weight loss J:136940
liver hemorrhage J:136940
liver vascular congestion J:136940
thrombocytopenia J:136940
tremors J:136940
Liftm1Stw/Liftm1Stw
involves: 129S1/Sv * BALB/c * C57BL/6J
abnormal skeleton morphology J:82113
postnatal lethality, incomplete penetrance J:82113
Liftm1Stw/Liftm1Stw
involves: 129S1/Sv * C57BL/6
abnormal astrocyte morphology J:137720
abnormal blood vessel morphology J:137720
abnormal brain vasculature morphology J:137720
abnormal capillary morphology J:137720
abnormal CNS glial cell morphology J:115507
abnormal glial cell morphology J:89814
abnormal induced retina neovascularization J:137720
abnormal retina vasculature morphology J:137720
abnormal skin vasculature morphology J:137720
decreased body size J:119777
decreased susceptibility to injury J:89814, J:137720
increased acute inflammation J:119777
increased circulating interleukin-1 beta level J:119777
increased vascular endothelial cell proliferation J:137720
normal nervous system phenotype J:115507
Liftm1Stw/Liftm1Stw
involves: 129S1/Sv * C57BL/6 * MF1
decreased circulating triglyceride level J:87585
increased circulating insulin-like growth factor I level J:87585
increased circulating leptin level J:87585
Liftm1Stw/Liftm1Stw
involves: 129S1/Sv * C57BL/6J
abnormal uterus morphology J:35071
decreased body weight J:35071
failure of embryo implantation J:35071
female infertility J:35071
postnatal growth retardation J:35071
Liftm1Stw/Liftm1Stw
involves: 129S1/Sv * MF1
abnormal osteoclast differentiation J:137646
abnormal osteoclast morphology J:137646
abnormal osteoclast physiology J:137646
decreased bone volume J:137646
hypoxia J:137646
increased bone resorption J:137646
increased osteoclast cell number J:137646

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory