Ldlr Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ldlr
low density lipoprotein receptor
MGI:96765

79 phenotypes from 4 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ldlr^Hlb301/Ldlr⁺ C57BL/6J-Ldlr^Hlb301/J	normal homeostasis/metabolism phenotype	J:82961
	increased circulating cholesterol level	J:82961
	increased circulating HDL cholesterol level	J:82961
	increased macrophage derived foam cell number	J:82961
	increased susceptibility to atherosclerosis	J:82961
Ldlr^Hlb301/Ldlr^Hlb301 C57BL/6J-Ldlr^Hlb301/J	gallstones	J:82961
	normal homeostasis/metabolism phenotype	J:82961
	increased circulating cholesterol level	J:82961
	increased circulating HDL cholesterol level	J:82961
	increased macrophage derived foam cell number	J:82961
	increased susceptibility to atherosclerosis	J:82961
	retina detachment	J:82961
Ldlr^Rgsc366/Ldlr⁺ involves: C57BL/6JJcl * DBA/2JJcl	increased circulating cholesterol level	J:133634
Ldlr^{tm1b(EUCOMM)Wtsi}/Ldlr^{tm1b(EUCOMM)Wtsi} C57BL/6N-Ldlr^{tm1b(EUCOMM)Wtsi}/Ieg	abnormal auditory brainstem response	J:211773
	decreased circulating unsaturated transferrin level	J:211773
	decreased locomotor activity	J:211773
	increased circulating cholesterol level	J:211773
	increased circulating HDL cholesterol level	J:211773
	increased circulating iron level	J:211773
	increased grip strength	J:211773
	increased mean corpuscular volume	J:211773
Ldlr^tm1Her/Ldlr⁺ B6.129S7-Ldlr^tm1Her	increased circulating cholesterol level	J:72027
Ldlr^tm1Her/Ldlr⁺ B6.129S7-Ldlr^tm1Her	increased circulating triglyceride level	J:72027
Ldlr^tm1Her/Ldlr⁺ involves: 129S7/SvEvBrd * C57BL/6 * DBA/2	hyperglycemia	J:100916
Ldlr^tm1Her/Ldlr^tm1Her B6.129S7-Ldlr^tm1Her	abnormal astrocyte morphology	J:137264
	abnormal circulating cholesterol level	J:100916, J:130278
	abnormal CNS glial cell morphology	J:137264
	abnormal fat pad morphology	J:130278
	abnormal microglial cell morphology	J:137264
	abnormal spatial learning	J:135078
	abnormal triglyceride level	J:130278
	amyloid beta deposits	J:137264
	atherosclerotic lesions	J:61287, J:110061
	decreased circulating HDL cholesterol level	J:130794
	decreased circulating interleukin-10 level	J:130794
	decreased susceptibility to weight gain	J:135078
	hepatic steatosis	J:130278
	hyperglycemia	J:100916, J:130278
	impaired glucose tolerance	J:130278
	impaired spatial working memory	J:137264
	increased circulating cholesterol level	J:61287, J:72027, J:135078, J:137264
	increased circulating HDL cholesterol level	J:72027
	increased circulating insulin level	J:130278
	increased circulating interleukin-1 beta level	J:137264
	increased circulating interleukin-6 level	J:137264
	increased circulating LDL cholesterol level	J:72027, J:130794
	increased circulating triglyceride level	J:72027, J:130278, J:137264
	increased circulating tumor necrosis factor level	J:137264
	increased circulating VLDL cholesterol level	J:130278, J:130794
	increased circulating VLDL triglyceride level	J:130278
	increased grip strength	J:135078
	increased liver cholesterol level	J:72027
	increased liver triglyceride level	J:130278
	increased locomotor activity	J:135078
	increased percent body fat/body weight	J:130278
	increased susceptibility to atherosclerosis	J:100916, J:110061, J:130794, J:135078
	increased susceptibility to weight gain	J:130278
Ldlr^tm1Her/Ldlr^tm1Her B6.129S7-Ldlr^tm1Her/J	abnormal adrenal gland morphology	J:85174
	abnormal liver physiology	J:106146
	alopecia	J:85174
	atherosclerotic lesions	J:103072
	decreased circulating triglyceride level	J:85174
	hepatic steatosis	J:85174
	normal homeostasis/metabolism phenotype	J:149005
	increased cholesterol level	J:85174
	increased circulating cholesterol level	J:85174, J:104609
	increased circulating HDL cholesterol level	J:85174
	increased circulating LDL cholesterol level	J:85174, J:149005
	increased circulating triglyceride level	J:149005
	increased circulating VLDL cholesterol level	J:85174, J:149005
	increased liver cholesterol level	J:85174
	scaly skin	J:85174
	thick skin	J:85174
Ldlr^tm1Her/Ldlr^tm1Her involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA	abnormal cholesterol homeostasis	J:75567
	abnormal circulating protein level	J:75567
	abnormal lipid homeostasis	J:75567
Ldlr^tm1Her/Ldlr^tm1Her involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6	atherosclerotic lesions	J:96110
	increased circulating cholesterol level	J:96110
Ldlr^tm1Her/Ldlr^tm1Her involves: 129S7/SvEvBrd	abnormal circulating cholesterol level	J:48202
	abnormal circulating LDL cholesterol level	J:84694
	atherosclerotic lesions	J:228420
	increased circulating cholesterol level	J:48202, J:84694, J:228420
	increased circulating LDL cholesterol level	J:84694, J:114949, J:169834
	increased circulating triglyceride level	J:48202
	increased susceptibility to atherosclerosis	J:228420
Ldlr^tm1Her/Ldlr^tm1Her involves: 129S7/SvEvBrd * C57BL/6	abnormal arteriole morphology	J:116493
	abnormal Bruch membrane morphology	J:132498
	abnormal choriocapillaris morphology	J:132498
	abnormal circulating amino acid level	J:146932
	abnormal glucose homeostasis	J:84844
	abnormal hippocampus morphology	J:127270
	abnormal microglial cell morphology	J:116493
	abnormal retina pigment epithelium morphology	J:132498
	abnormal short-term spatial reference memory	J:116493, J:120389
	abnormal spatial learning	J:116493, J:120389
	abnormal synapse morphology	J:43043
	abnormal synaptic bouton morphology	J:120389, J:127270
	decreased circulating corticosterone level	J:108412
	decreased lean body mass	J:84844
	impaired glucose tolerance	J:84844
	increased circulating alanine transaminase level	J:175559
	increased circulating cholesterol level	J:175559
	increased circulating free fatty acids level	J:175559
	increased circulating glucose level	J:84844
	increased circulating insulin level	J:84844
	increased circulating LDL cholesterol level	J:102291
	increased circulating triglyceride level	J:175559
	increased hepatocyte apoptosis	J:175559
	increased liver cholesterol level	J:175559
	increased liver triglyceride level	J:175559
	increased liver weight	J:175559
	insulin resistance	J:84844
	liver fibrosis	J:175559
	liver inflammation	J:175559
	macrovesicular hepatic steatosis	J:175559
	maternal effect	J:146932
	microvesicular hepatic steatosis	J:175559
	obese	J:175559
	oxidative stress	J:175559
	photoreceptor outer segment degeneration	J:132498
Ldlr^tm1Her/Ldlr^tm1Her involves: 129S7/SvEvBrd * C57BL/6 * SJL	increased circulating cholesterol level	J:114480
	increased circulating LDL cholesterol level	J:114480
Ldlr^tm1Her/Ldlr^tm1Her involves: 129S7/SvEvBrd * C57BL/6J	atherosclerotic lesions	J:29950
	increased circulating cholesterol level	J:29950
	increased susceptibility to atherosclerosis	J:29950

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23