34 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cblbtm1Pngr/Cblbtm1Pngr Itktm1Litt/Itktm1Litt B6.129-Itktm1Litt Cblbtm1Pngr	abnormal T cell morphology	J:141390
	abnormal T-helper 2 cell differentiation	J:141390
	decreased interleukin-2 secretion	J:141390
	decreased T cell number	J:141390
	normal immune system phenotype	J:141390
H2b/H2b Itktm1Ljb/Itktm1Ljb Tg(TcrAND)53Hed/? involves: C3H/HeJ * C57BL/6 * C57BL/10	abnormal positive T cell selection	J:123795
	decreased CD4-positive, alpha-beta T cell number	J:123795
H2b/H2k Itktm1Ljb/Itktm1Ljb Tg(TcrAND)53Hed/? involves: C3H/HeJ * C57BL/6 * C57BL/10	abnormal positive T cell selection	J:123795
	decreased CD4-positive, alpha-beta T cell number	J:123795
Il4tm1Lky/Il4tm1Lky Itktm1Litt/Itktm1Litt involves: 129S4/SvJae * BALB/c * C57BL/6J	abnormal cell death	J:129883
	abnormal cytokine secretion	J:129883
	abnormal response to infection	J:129883
	abnormal T-helper 2 physiology	J:129883
	normal immune system phenotype	J:129883
Il15tm1Imx/Il15tm1Imx Itktm1Litt/Itktm1Litt involves: 129S4/SvJae * C57BL/6	abnormal thymus cell ratio	J:111786
Il15tm1Imx/Il15tm1Imx Itktm1Ljb/Itktm1Ljb involves: 129 * C57BL/6 * C57BL/10	decreased CD8-positive, alpha-beta T cell number	J:113408
Itktm1Litt/Itktm1Litt Tg(DO11.10)10Dlo/0 involves: 129S4/SvJae * BALB/c * C3H * C57BL/6J	abnormal T-helper 2 physiology	J:129883
Itktm1Litt/Itktm1Litt Tg(TcraH-Y,TcrbH-Y)71Vbo/0 involves: 129S4/SvJae * C57BL/6 * DBA/2J	abnormal positive T cell selection	J:31230
	decreased CD4-positive, alpha-beta T cell number	J:31230
	increased double-positive T cell number	J:31230
Itktm1Litt/Itktm1Litt Tg(TcrAND)53Hed/0 involves: 129S4/SvJae * C57BL/6 * SJL	abnormal lymphocyte morphology	J:31230
	decreased CD4-positive, alpha-beta T cell number	J:31230
	increased double-negative T cell number	J:31230
Itktm1Litt/Itktm1Litt Txktm1Pls/Txktm1Pls involves: 129S4/SvJae * 129S6/SvEvTac	decreased CD4-positive, alpha-beta T cell number	J:54449
	decreased single-positive T cell number	J:54449
	decreased T cell proliferation	J:54449
	increased susceptibility to parasitic infection	J:54449
Itktm1Litt/Itktm1Litt Vav1tm2Bbd/Vav1tm2Bbd B6.129-Itktm1Litt Vav1tm2Bbd	abnormal CD4-positive T cell differentiation	J:141390
	abnormal CD8-positive, alpha-beta T cell differentiation	J:141390
	abnormal positive T cell selection	J:141390
	abnormal T cell morphology	J:141390
	abnormal T cell physiology	J:141390
	decreased CD4-positive, alpha-beta T cell number	J:141390
	decreased CD8-positive, alpha-beta T cell number	J:141390
	decreased double-positive T cell number	J:141390
	decreased T cell number	J:141390
	decreased thymocyte number	J:141390
	increased B cell number	J:141390
	increased T cell apoptosis	J:141390
Itktm1Ljb/Itktm1Ljb Rag1tm1Mom/Rag1tm1Mom Tg(Tcra5CC7,Tcrb5CC7)IWep/? involves: 129 * C57BL/10	abnormal CD4-positive T cell differentiation	J:93606
	decreased interferon-gamma secretion	J:93606
	decreased interleukin-4 secretion	J:93606
	decreased interleukin-5 secretion	J:93606
	decreased interleukin-10 secretion	J:93606
Itktm1Ljb/Itktm1Ljb Tcrdtm1Mom/Tcrdtm1Mom involves: 129 * C57BL/6 * C57BL/10	normal immune system phenotype	J:148531
Itktm1Ljb/Itktm1Ljb Tg(Tcra2B4)1Mmd/? Tg(Tcrb2B4)1Mmd/? involves: C3H/HeJ * C57BL/6 * C57BL/10	decreased CD4-positive, alpha-beta T cell number	J:123795
Itktm1Ljb/Itktm1Ljb Tg(Tcra5CC7,Tcrb5CC7)IWep/? involves: 129 * C57BL/10	decreased CD4-positive, alpha-beta T cell number	J:123795
Itktm1Ljb/Itktm1Ljb Tg(TcraTcrb)1100Mjb/? involves: 129 * C57BL/6 * C57BL/10	normal immune system phenotype	J:113408
Itktm1Ljb/Itktm1Ljb Txktm1Pls/Txktm1Pls B6.129-Txktm1Pls Itktm1Ljb	abnormal CD8-positive, alpha-beta T cell physiology	J:113408
	increased CD8-positive, alpha-beta T cell number	J:113408
	increased interferon-gamma secretion	J:113408
	increased memory T cell number	J:113408