Itk Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Itk
IL2 inducible T cell kinase
MGI:96621

41 phenotypes from 6 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Itk^em1(IMPC)Mbp/Itk^em1(IMPC)Mbp C57BL/6N-Itk^em1(IMPC)Mbp/MbpMmucd	abnormal spleen morphology	J:211773
	enlarged spleen	J:211773
	increased startle reflex	J:211773
Itk^m1Btlr/Itk^m1Btlr C57BL/6J-Itk^m1Btlr	abnormal CD4-positive, alpha-beta T cell physiology	J:236673
	abnormal CD8-positive, alpha-beta T cell physiology	J:236673
	abnormal cell proliferation	J:236673
	increased CD8-positive, alpha-beta memory T cell proliferation	J:236673
	increased IgE level	J:236673
Itk^m2Btlr/Itk^m2Btlr C57BL/6J-Itk^m2Btlr	decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:254826
	decreased CD8-positive, alpha-beta memory T cell number	J:254826
	decreased CD8-positive, naive alpha-beta T cell number	J:254826
	increased B cell number	J:254826
	increased central memory CD4-positive, alpha-beta T cell number	J:254826
	increased central memory CD8 positive, alpha-beta T cell number	J:254826
	increased effector memory CD4-positive, alpha-beta T cell number	J:254826
Itk^tm1Lex/Itk^tm1Lex involves: 129S5/SvEvBrd * C57BL/6J	decreased CD4-positive, alpha-beta T cell number	J:103485
	decreased CD8-positive, alpha-beta T cell number	J:103485
	increased B cell number	J:103485
Itk^tm1Litt/Itk^tm1Litt B6.129S4-Itk^tm1Litt	abnormal positive T cell selection	J:141390
	abnormal T cell morphology	J:141390
	decreased interleukin-2 secretion	J:141390
	decreased T cell number	J:141390
	decreased T cell proliferation	J:141390
	increased double-negative T cell number	J:141390
Itk^tm1Litt/Itk^tm1Litt involves: 129S4/SvJae	decreased T cell proliferation	J:54449
Itk^tm1Litt/Itk^tm1Litt involves: 129S4/SvJae	increased susceptibility to parasitic infection	J:54449
Itk^tm1Litt/Itk^tm1Litt involves: 129S4/SvJae * C57BL/6	abnormal CD8-positive, alpha-beta T cell differentiation	J:111786
	abnormal thymus cell ratio	J:111786
	decreased CD8-positive, alpha-beta T cell number	J:111786
Itk^tm1Litt/Itk^tm1Litt involves: 129S4/SvJae * C57BL/6J	decreased B cell number	J:31230
	decreased CD4-positive, alpha-beta T cell number	J:31230
	decreased T cell number	J:31230
	decreased T cell proliferation	J:31230
	normal immune system phenotype	J:31230
Itk^tm1Ljb/Itk^tm1Ljb B6.129-Itk^tm1Ljb	abnormal NK T cell morphology	J:120689
Itk^tm1Ljb/Itk^tm1Ljb B6.129-Itk^tm1Ljb	decreased NK T cell number	J:120689
Itk^tm1Ljb/Itk^tm1Ljb B10.129-Itk^tm1Ljb	abnormal CD8-positive, alpha-beta T cell differentiation	J:113408
	abnormal CD8-positive, alpha-beta T cell physiology	J:113408
	abnormal gamma-delta T cell morphology	J:148531
	decreased CD4-positive, alpha-beta T cell number	J:123795
	decreased interferon-gamma secretion	J:148531
	increased CD8-positive, alpha-beta T cell number	J:113408, J:123795
	increased germinal center B cell number	J:148531
	increased IgE level	J:148531
	increased interferon-gamma secretion	J:113408
	increased interleukin-4 secretion	J:148531
	increased interleukin-10 secretion	J:148531
	increased interleukin-13 secretion	J:148531
	increased mature gamma-delta T cell number	J:148531
	increased memory T cell number	J:113408
Itk^tm1Ljb/Itk^tm1Ljb involves: 129 * C57BL/6	abnormal T cell activation	J:48231
	decreased CD4-positive, alpha-beta T cell number	J:48231
	decreased interleukin-2 secretion	J:48231

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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