Itgax Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Itgax
integrin alpha X
MGI:96609

12 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Itgax^M1Btlr/Itgax⁺ C57BL/6J-Itgax^M1Btlr	decreased dendritic cell number	J:236684
	impaired hematopoiesis	J:236684
	increased plasmacytoid dendritic cell number	J:236684
Itgax^M1Btlr/Itgax^M1Btlr C57BL/6J-Itgax^M1Btlr	decreased dendritic cell number	J:236684
	impaired hematopoiesis	J:236684
	increased plasmacytoid dendritic cell number	J:236684
Itgax^tm1Bll/Itgax^tm1Bll B6.129S7-Itgax^tm1Bll	decreased interferon-gamma secretion	J:122187
	decreased interleukin-17 secretion	J:122187
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:122187
	decreased tumor necrosis factor secretion	J:122187
	increased interleukin-2 secretion	J:122187
	increased interleukin-12 secretion	J:122187
	increased susceptibility to bacterial infection	J:94855
	increased T cell proliferation	J:122187
Itgax^tm1Bll/Itgax^tm1Bll involves: 129S7/SvEvBrd	no abnormal phenotype detected	J:90954

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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