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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Itga5
integrin alpha 5 (fibronectin receptor alpha)
MGI:96604
13 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm1Sho/0
Itga5tm2Hyn/Itga5tm1Hyn
Itgavtm1Hyn/Itgavtm2Hyn
Tg(Tek-cre)1Ywa/0
involves: 129 * C57BL/6 * SJL 		abnormal ascending aorta morphology J:161850
lethality throughout fetal growth and development, complete penetrance J:161850
patent ductus arteriosus J:161850
retroesophageal right subclavian artery J:161850
vascular ring J:161850
ventricular septal defect J:161850
Gt(ROSA)26Sortm1Sho/0
Itga5tm2Hyn/Itga5tm1Hyn
Itgavtm2Hyn/Itgav+
Tg(Tek-cre)1Ywa/0
involves: 129 * C57BL/6 * SJL 		patent ductus arteriosus J:161850
postnatal lethality, incomplete penetrance J:161850
ventricular septal defect J:161850
Itga3tm1Jak/Itga3+
Itga5tm1Hyn/Itga5+
Itga8tm1Lfr/Itga8+
involves: 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * C57BL/6J 		abnormal spatial learning J:84858
reduced long-term potentiation J:84858
Itga5tm1Hyn/Itga5+
Nischedsn/Nisch+
C3H.Cg-Nischedsn Itga5tm1Hyn 		impaired hearing J:244907
increased susceptibility to otitis media J:244907
Itga5tm1Hyn/Itga5+
Nischedsn/Nischedsn
C3H.Cg-Nischedsn Itga5tm1Hyn 		impaired hearing J:244907
increased or absent threshold for auditory brainstem response J:244907
increased susceptibility to otitis media J:244907
Itga5tm1Hyn/Itga5tm2Hyn
Tg(H2-K1-tsA58)6Kio/0
Tg(Tek-cre)1Ywa/0
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca * SJL 		abnormal cell adhesion J:161850
Itga5tm2Hyn/Itga5tm2Hyn
Itgavtm2Hyn/Itgavtm2Hyn
Tg(H2-K1-tsA58)6Kio/0
involves: 129 * C57BL/6 * SJL 		abnormal cell adhesion J:161850
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory