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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Itga4
integrin alpha 4
MGI:96603
32 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Itga4tm1Hyn/Itga4tm1Hyn
either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6J)
abnormal allantois morphology J:23140
abnormal cardiovascular system morphology J:23140
abnormal coronary vessel morphology J:23140
abnormal craniofacial morphology J:23140
abnormal epicardium morphology J:23140
abnormal placenta morphology J:23140
dilated allantois J:23140
embryonic lethality during organogenesis, incomplete penetrance J:23140
failure of chorioallantoic fusion J:23140
heart hemorrhage J:23140
Itga4tm1Hyn/Itga4tm1Jty
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6N
abnormal epicardium morphology J:76747
Itga4tm1Jty/Itga4tm1Jty
involves: 129S6/SvEvTac * C57BL/6N
abnormal epicardium morphology J:76747
embryonic lethality during organogenesis, complete penetrance J:76747
failure of chorioallantoic fusion J:76747
heart hemorrhage J:76747
Itga4tm1Leg/Itga4tm1Leg
Not Specified
abnormal cell physiology J:151371
Itga4tm1Mgin/Itga4tm1Mgin
B6.129-Itga4tm1Mgin
abnormal B cell physiology J:106471
abnormal lymphocyte physiology J:106471
abnormal T cell physiology J:106471
decreased monocyte cell number J:106471
decreased Peyer's patch number J:106471
impaired macrophage chemotaxis J:106471
Itga4tm1Mgin/Itga4tm1Mgin
Not Specified
abnormal cell physiology J:151371
Itga4tm1Mshi/Itga4tm1Mshi
C57BL/6-Itga4tm1Mshi
abnormal cellular extravasation J:144092
abnormal leukocyte adhesion J:144092
abnormal leukocyte migration J:144092
abnormal mononuclear cell morphology J:144092
decreased B cell number J:144092
decreased lymphocyte cell number J:144092
decreased T cell number J:144092
small Peyer's patches J:144092
Itga4tm1Tpa/Itga4tm1Tpa
Tg(Mx1-cre)1Cgn/?
involves: 129S4/SvJaeSor * C57BL/6 * CBA
abnormal B cell differentiation J:86861
abnormal definitive hematopoiesis J:86861
abnormal myeloblast morphology/development J:86861
abnormal reticulocyte morphology J:86861
decreased CD4-positive, alpha beta T cell number J:86861
increased leukocyte cell number J:86861

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory