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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Il6
interleukin 6
MGI:96559
44 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
ApcMin/Apc+
Il6tm1Kopf/Il6tm1Kopf
involves: 129S2/SvPas * C57BL/6 		abnormal tumor incidence J:130429
normal adipose tissue phenotype J:130429
normal muscle phenotype J:130429
Ash1lTn(pb-Act-RFP)1.AF0-180T25Zhu/Ash1lTn(pb-Act-RFP)1.AF0-180T25Zhu
Il6tm1Kopf/Il6tm1Kopf
B6.Cg-Ash1lTn(pb-Act-RFP)1.AF0-180T25Zhu Il6tm1Kopf 		abnormal inflammatory response J:208213
increased susceptibility to induced arthritis J:208213
Cebpbtm1Vpo/Cebpbtm1Vpo
Il6tm1Poli/Il6tm1Poli
involves: 129S/SvEv * MF1 		normal hematopoietic system phenotype J:35883
Ctsctm1Ley/Ctsctm1Ley
Il6tm1Kopf/Il6tm1Kopf
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 		normal immune system phenotype J:88160
Foxp3tm1Kuch/?
Il6tm1Kopf/Il6tm1Kopf
involves: 129S2/SvPas * C57BL/6 		abnormal CD4-positive T cell differentiation J:123352
decreased circulating interleukin-6 level J:123352
decreased interleukin-17 secretion J:123352
decreased susceptibility to experimental autoimmune encephalomyelitis J:123352
increased regulatory T cell number J:123352
Galctwi/Galctwi
Il6tm1Kopf/Il6tm1Kopf
involves: 129S2/SvPas * C57BL/6J * CE/J 		abnormal blood-brain barrier function J:56656
abnormal cerebellum white matter morphology J:56656
abnormal tumor necrosis factor level J:56656
gliosis J:56656
tremors J:56656
Il6tm1Kopf/Il6+
Prdm1tm1Clme/Prdm1tm1Clme
Tg(Itgax-cre)1-1Reiz/0
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CBA 		normal immune system phenotype J:178876
Il6tm1Kopf/Il6+
Tg(ED-L2-IL1RN/IL1B)#Tcw/?
B6.Cg-Il6tm1Kopf Tg(ED-L2-IL1RN/IL1B)#Tcw 		normal digestive/alimentary phenotype J:180282
esophageal inflammation J:180282
Il6tm1Kopf/Il6+
Ncoa5tm1Hxia/Ncoa5+
involves: 129 * 129S2/SvPas * C57BL/6 		abnormal epididymis physiology J:284227
enhanced male fertility J:284227
increased sperm motility J:284227
increased sperm progressive motility J:284227
teratozoospermia J:284227
Il6tm1Kopf/Il6+
Ncoa5tm1Hxia/Ncoa5+
involves: 129S2/SvPas * BALB/c * C57BL/6 		normal homeostasis/metabolism phenotype J:207622
Il6tm1Kopf/Il6+
Ncoa5tm1Hxia/Ncoa5+
involves: 129S2/SvPas * C57BL/6 		normal homeostasis/metabolism phenotype J:207622
increased hepatocellular carcinoma incidence J:207622
normal reproductive system phenotype J:207622
Il6tm1Kopf/Il6+
Ncoa5tm1Hxia/Ncoa5tm1Hxia
involves: 129S2/SvPas * C57BL/6 		preweaning lethality, complete penetrance J:207622
Il6tm1Kopf/Il6tm1Kopf
Il6ratm1.2Drew/Il6ratm1.2Drew
involves: 129S2/SvPas * C57BL/6 * C57BL/6N * FVB/N * SJL 		abnormal wound healing J:160966
Il6tm1Kopf/Il6tm1Kopf
Il6sttm1Ern/Il6sttm1Ern
involves: 129S1/Sv * 129S2/SvPas 		decreased susceptibility to endotoxin shock J:168781
normal immune system phenotype J:139226
Il6tm1Kopf/Il6tm1Kopf
Inpp5dtm1Rkh/Inpp5dtm1Rkh
involves: 129 * C57BL/6 		abnormal hematopoietic stem cell morphology J:117320
abnormal lymphopoiesis J:117320
abnormal myelopoiesis J:117320
decreased pro-B cell number J:117320
Il6tm1Kopf/Il6tm1Kopf
Junbtm3Wag/Junbtm3Wag
Tg(KRT5-cre)1Tak/0
involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6 		normal homeostasis/metabolism phenotype J:155575
hyperkeratosis J:155575
normal immune system phenotype J:155575
normal integument phenotype J:155575
normal mortality/aging J:155575
normal renal/urinary system phenotype J:155575
skin inflammation J:155575
thick skin J:155575
Il6tm1Kopf/Il6tm1Kopf
Liftm1Stw/Liftm1Stw
involves: 129S1/Sv * 129S2/SvPas * C57BL/6 		abnormal glial cell morphology J:89814
decreased susceptibility to injury J:89814
Il6tm1Kopf/Il6tm1Kopf
Npc1m1N/Npc1m1N
involves: 129S2/SvPas * BALB/c * C57BL/6 		abnormal glial cell physiology J:118352
Il6tm1Kopf/Il6tm1Kopf
Tanktm1Aki/Tanktm1Aki
involves: 129/Sv * 129S2/SvPas * C57BL/6 		normal immune system phenotype J:151757
Il6tm1Kopf/Il6tm1Kopf
Tg(ED-L2-IL1RN/IL1B)#Tcw/?
B6.Cg-Il6tm1Kopf Tg(ED-L2-IL1RN/IL1B)#Tcw 		normal digestive/alimentary phenotype J:180282
esophageal inflammation J:180282
Il6tm1Kopf/Il6tm1Kopf
Tg(H2-K-IL6)2Srj/0
involves: 129S2/SvPas * C57BL/6 * DBA/2 		normal hematopoietic system phenotype J:185153
Il11ra1tm1Wehi/Il11ra1tm1Wehi
Il6tm1Kopf/Il6tm1Kopf
involves: 129/Sv * C57BL/6 		increased susceptibility to induced colitis J:79073
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory