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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Il2
interleukin 2
MGI:96548
34 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
B2mtm1Unc/B2mtm1Unc
Il2tm1Hor/Il2tm1Hor
involves: 129 * C57BL/6 		abnormal CD4-positive T cell differentiation J:39981
abnormal CD4-positive, alpha-beta T cell physiology J:51450
abnormal CD8 positive, alpha-beta intraepithelial T cell morphology J:39981
abnormal CD8-positive, alpha beta T cell morphology J:51450
abnormal CD8-positive, alpha-beta cytotoxic T cell morphology J:39981
cachexia J:39981, J:51450
colitis J:39981, J:51450
diarrhea J:39981, J:51450
increased intestinal adenocarcinoma incidence J:51450
rectal prolapse J:51450
B2mtm1Unc/B2mtm1Unc
Il2tm1Hor/Il2tm1Hor
involves: 129P2/OlaHsd 		normal reproductive system phenotype J:134589
Igh-Jtm1Dhu/Igh-J+
Il2tm1Hor/Il2tm1Hor
involves: 129/Sv * C57BL/6 		abnormal intestinal epithelium morphology J:29999
abnormal intestinal goblet cell morphology J:29999
anemia J:29999
cachexia J:29999
colitis J:29999
diarrhea J:29999
enlarged mesenteric lymph nodes J:29999
hunched posture J:29999
rectal hemorrhage J:29999
rectal prolapse J:29999
Igh-Jtm1Dhu/Igh-Jtm1Dhu
Il2tm1Hor/Il2tm1Hor
involves: 129/Sv * C57BL/6 		abnormal blood cell morphology/development J:29999
abnormal intestinal epithelium morphology J:29999
abnormal intestinal goblet cell morphology J:29999
cachexia J:29999
colitis J:29999
diarrhea J:29999
enlarged mesenteric lymph nodes J:29999
hunched posture J:29999
rectal hemorrhage J:29999
rectal prolapse J:29999
Il2tm1Hor/Il2tm1Hor
Il4tm1Cgn/Il4tm1Cgn
involves: 129P2/OlaHsd * C57BL/6 		abnormal susceptibility to Riboviria infection J:26861
decreased cytotoxic T cell cytolysis J:26861
decreased IgG level J:16662, J:26861
increased B cell proliferation J:16662
increased pre-B cell number J:16662
increased pro-B cell number J:16662
increased T cell proliferation J:16662
Il2tm1Hor/Il2tm1Hor
Rag2tm1Fwa/Rag2+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 		abnormal intestinal epithelium morphology J:29999
abnormal intestinal goblet cell morphology J:29999
anemia J:29999
cachexia J:29999
colitis J:29999
diarrhea J:29999
enlarged mesenteric lymph nodes J:29999
hunched posture J:29999
rectal hemorrhage J:29999
rectal prolapse J:29999
Il2tm1Hor/Il2tm1Hor
Rag2tm1Fwa/Rag2tm1Fwa
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 		abnormal blood cell morphology/development J:29999
normal immune system phenotype J:29999
Il2tm1Hor/Il2tm1Hor
Rag2tm1Fwa/Rag2tm1Fwa
Tg(Tcra5CC7,Tcrb5CC7)IWep/0
involves: 129P2/OlaHsd * C57BL/10 		abnormal T cell number J:120176
increased T-helper 17 cell number J:120176
Il2tm1Hor/Il2tm1Hor
Tcrbtm1Mom/Tcrbtm1Mom
involves: 129P2/OlaHsd * C57BL/6 		normal digestive/alimentary phenotype J:135589
normal immune system phenotype J:135589
Il2tm1Hor/Il2tm1Hor
Tg(DO11.10)10Dlo/?
C.Cg-Il2tm1Hor Tg(DO11.10)10Dlo 		abnormal regulatory T cell physiology J:88349
increased activated T cell number J:88349
increased T cell proliferation J:88349
premature death J:88349
Il2tm1Hor/Il2tm1Hor
Tg(Pgk1-HA)1.1Vbo/?
Tg(Tcra/Tcrb)1Vbo/?
C.Cg-Il2tm1Hor Tg(Pgk1-HA)1.1Vbo Tg(Tcra/Tcrb)1Vbo 		abnormal regulatory T cell physiology J:112603
decreased regulatory T cell number J:112603
increased regulatory T cell number J:112603
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory