About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Il10
interleukin 10
MGI:96537
63 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Apoetm1Unc/Apoetm1Unc
Il10tm1Cgn/Il10tm1Cgn
involves: 129P2/OlaHsd * C57BL/6 		abnormal arterial thrombosis J:105858
abnormal blood coagulation J:105858
abnormal circulating cholesterol level J:105858
abnormal circulating cytokine level J:105858
decreased circulating VLDL cholesterol level J:105858
increased circulating interferon-gamma level J:105858
increased circulating interleukin-12 level J:105858
increased circulating LDL cholesterol level J:105858
increased susceptibility to atherosclerosis J:105858
Cd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm2(Cd74/MOG)Awai/Gt(ROSA)26Sor+
Il10tm1Roer/Il10tm1Roer
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell physiology J:140751
decreased susceptibility to experimental autoimmune encephalomyelitis J:140751
Cd44tm1.1Ugu/Cd44tm1.1Ugu
Il10tm1Cgn/Il10tm1Cgn
involves: 129/Sv * C57BL/6 		abnormal immune system physiology J:62867
weight loss J:62867
Faslpr/Faslpr
Tg(INS-Il10)#Sar/0
NOD.Cg-Faslpr Tg(INS-Il10)#Sar 		increased susceptibility to autoimmune diabetes J:64051
insulitis J:64051
Icam1tm1Jcgr/Icam1tm1Jcgr
Tg(INS-Il10)#Sar/0
NOD.Cg-Icam1tm1Jcgr Tg(INS-Il10)#Sar 		decreased susceptibility to autoimmune diabetes J:66103
periinsulitis J:66103
Il10tm1Cgn/Il10tm1Cgn
Il4tm1Cgn/Il4tm1Cgn
involves: 129P2/OlaHsd * C57BL/6 		abnormal T-helper 1 cell differentiation J:111712
increased interferon-gamma secretion J:111712
Il10tm1Cgn/Il10tm1Cgn
Il12btm1Jm/Il12btm1Jm
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 		abnormal T-helper 2 cell differentiation J:111712
increased interleukin-13 secretion J:111712
Il10tm1Cgn/Il10tm1Cgn
Il27ratm1Mak/Il27ratm1Mak
involves: 129P2/OlaHsd * C57BL/6 		abnormal T-helper 1 physiology J:136179
abnormal T-helper 2 physiology J:136179
colitis J:136179
decreased interferon-gamma secretion J:136179
decreased susceptibility to induced colitis J:136179
extended life span J:136179
increased interleukin-13 secretion J:136179
Il10tm1Cgn/Il10tm1Cgn
Nfil3tm1Look/Nfil3tm1Look
involves: 129P2/OlaHsd * 129X1/SvJ 		colitis J:209365
increased interleukin-12 secretion J:209365
Il10tm1Cgn/Il10tm1Cgn
Nfil3tm1Pbro/Nfil3tm1Pbro
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 		colitis J:209365
decreased colon length J:209365
diarrhea J:209365
increased interleukin-12 secretion J:209365
rectal prolapse J:209365
Il10tm1Cgn/Il10tm1Cgn
Nos2tm1Lau/Nos2tm1Lau
involves: 129P2/OlaHsd * C57BL/6 		increased myocardial infarct size J:70292
Il10tm1Cgn/Il10tm1Cgn
Rps6ka4tm1Jsca/Rps6ka4tm1Jsca
Rps6ka5tm1Jsca/Rps6ka5tm1Jsca
B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca 		decreased interleukin-10 secretion J:139576
increased interleukin-6 secretion J:139576
increased interleukin-12a secretion J:139576
increased interleukin-12b secretion J:139576
increased tumor necrosis factor secretion J:139576
Il10tm1Cgn/Il10tm1Cgn
Rreb1Sao/Rreb1Sao
NOD.Cg-Il10tm1Cgn Rreb1Sao 		ataxia J:237902
decreased Purkinje cell number J:237902
rectal prolapse J:237902
tremors J:237902
Il10tm1Cgn/Il10tm1Cgn
Tg(MUC1)79.24Gend/0
B6.Cg-Il10tm1Cgn Tg(MUC1)79.24Gend 		increased colon adenocarcinoma incidence J:149347
large intestinal inflammation J:149347
rectal prolapse J:149347
Il10tm1Cgn/Il10tm1Cgn
Tg(Vil1-cre)997Gum/?
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac * SJL 		abnormal gut flora balance J:229155
colitis J:229155
premature death J:229155
rectal prolapse J:229155
Il10tm1Cgn/Il10tm1Cgn
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac 		colitis J:229155
premature death J:229155
rectal prolapse J:229155
Il10tm1Cgn/Il10tm1Cgn
Vdrtm1Mbd/Vdrtm1Mbd
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		abnormal CD4-positive, alpha-beta T cell physiology J:107077
abnormal cytokine level J:107077
abnormal lymph node cell ratio J:107077
abnormal splenic cell ratio J:107077
abnormal thymus corticomedullary boundary morphology J:107077
abnormal thymus involution J:107077
absent spleen white pulp J:107077
anemia J:107077
colitis J:107077
decreased lymphocyte cell number J:107077
decreased T cell proliferation J:107077
enlarged mesenteric lymph nodes J:107077
enlarged spleen J:107077
increased macrophage cell number J:107077
increased neutrophil cell number J:107077
increased spleen red pulp amount J:107077
increased T cell apoptosis J:107077
intestinal inflammation J:107077
rectal prolapse J:107077
thymus hypoplasia J:107077
Il10tm1Keny/Il10+
Nfil3tm1.1Kubo/Nfil3tm1.1Kubo
involves: 129 * C57BL/6 		decreased interleukin-10 secretion J:172134
Prf1tm1Clrk/Prf1tm1Clrk
Tg(INS-Il10)#Sar/0
involves: 129S7/SvEvBrd * BALB/c * NOD 		decreased susceptibility to autoimmune diabetes J:64051
Prkdcscid/Prkdcscid
Tg(INS-Il10)#Sar/0
NOD.Cg-Prkdcscid Tg(INS-Il10)#Sar 		increased susceptibility to autoimmune diabetes J:66103
Tg(INS-Il10)#Sar/0
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6J * NOD 		increased circulating glucose level J:64051
increased susceptibility to autoimmune diabetes J:64051
Tg(INS-Il10)#Sar/0
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129S2/SvPas * C57BL/6J * NOD 		increased circulating glucose level J:64051
increased susceptibility to autoimmune diabetes J:64051
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory