About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Il10
interleukin 10
MGI:96537
152 phenotypes from 11 alleles in 16 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Il10tm1Roer/Il10tm1Roer
involves: 129P2/OlaHsd
abnormal CD8-positive, alpha-beta T cell physiology J:151551
abnormal myeloid leukocyte morphology J:151551
decreased circulating interleukin-10 level J:151551
increased B cell number J:151551
increased CD4-positive, alpha beta T cell number J:151551
increased plasma cell number J:151551
Il10tm1.1Karp/Il10tm1.1Karp
involves: C57BL/6
no abnormal phenotype detected J:151551
Il10tm1.1Roer/Il10tm1.1Roer
involves: 129P2/OlaHsd
abnormal myeloid leukocyte morphology J:151551
decreased circulating interleukin-10 level J:151551
increased B cell number J:151551
increased myeloid dendritic cell number J:151551
increased plasma cell number J:151551
increased susceptibility to endotoxin shock J:151551
increased T cell number J:151551
spleen hyperplasia J:151551
Il10tm1.1Roer/Il10tm1.1Roer
involves: 129P2/OlaHsd * C57BL/6
abnormal cytokine secretion J:94537
abnormal hypersensitivity reaction J:94537
abnormal innate immunity J:94537
increased sensitivity to induced morbidity/mortality J:94537
increased susceptibility to bacterial infection J:94537
intestinal inflammation J:94537
Il10tm1Cgn/Il10tm1Cgn
129S.Cg-Il10tm1Cgn
decreased vasoconstriction J:59742
Il10tm1Cgn/Il10tm1Cgn
B6.129P2-Il10tm1Cgn
abnormal circulating interleukin-6 level J:191723
abnormal circulating interleukin-12b level J:191723
Il10tm1Cgn/Il10tm1Cgn
B6.129P2-Il10tm1Cgn/J
abnormal chemokine level J:157787
abnormal cytokine level J:139972, J:157787
abnormal neuron physiology J:108086
abnormal regulatory T cell physiology J:125748
abnormal sleep pattern J:114404
cecum inflammation J:157787
decreased mean systemic arterial blood pressure J:146372
decreased susceptibility to induced choroidal neovascularization J:134144
decreased vasoconstriction J:59742
impaired adaptive thermogenesis J:114404
impaired coordination J:139972
impaired exercise endurance J:139972
increased cerebral infarction size J:108086
increased circulating interferon-gamma level J:157787
increased circulating interleukin-1 alpha level J:157787
increased circulating interleukin-1 beta level J:139972, J:157787
increased circulating interleukin-2 level J:157787
increased circulating interleukin-6 level J:139972, J:157787
increased circulating interleukin-12 level J:157787
increased circulating interleukin-17 level J:157787
increased circulating tumor necrosis factor level J:157787
increased colon adenocarcinoma incidence J:149347
increased susceptibility to induced colitis J:157787
increased susceptibility to neuronal excitotoxicity J:108086
increased susceptibility to parasitic infection J:157787
increased vasoconstriction J:146372
large intestinal inflammation J:149347
rectal prolapse J:149347
slow postnatal weight gain J:124308
Il10tm1Cgn/Il10tm1Cgn
B10.129P2(B6)-Il10tm1Cgn/J
decreased length of allograft survival J:44346
Il10tm1Cgn/Il10tm1Cgn
involves: 129P2/OlaHsd
abnormal cytokine secretion J:117122
abnormal inflammatory response J:117122
abnormal reproductive system physiology J:130208
increased circulating interleukin-12 level J:118833
increased circulating tumor necrosis factor level J:118833
increased susceptibility to endotoxin shock J:117122, J:118833
intestinal inflammation J:113376
rectal prolapse J:209365
Il10tm1Cgn/Il10tm1Cgn
involves: 129P2/OlaHsd * 129S/SvEv
abnormal intestine physiology J:59872
colitis J:59872
decreased body weight J:59872
Il10tm1Cgn/Il10tm1Cgn
involves: 129P2/OlaHsd * C57BL/6
abnormal bone mineralization J:93577
abnormal bone structure J:93577
abnormal circulating enzyme level J:110238
abnormal circulating protein level J:110238
abnormal circulating serum albumin level J:93577
abnormal colon morphology J:107077
abnormal crypts of Lieberkuhn morphology J:15222
abnormal cytokine level J:35020
abnormal enterocyte morphology J:15222
abnormal glucose homeostasis J:129479
abnormal homeostasis J:129479
abnormal immune system physiology J:35020
abnormal interferon level J:35020, J:107077, J:125760
abnormal interleukin level J:35020, J:51636, J:107077
abnormal intestinal epithelium morphology J:15222
abnormal intestinal mucosa morphology J:15222, J:68476
abnormal iron level J:15222
abnormal Langerhans cell physiology J:51636
abnormal large intestine morphology J:35020
abnormal leukocyte morphology J:35020
abnormal level of surface class II molecules J:15222
abnormal lipid level J:129479
abnormal liver physiology J:129479
abnormal lymphocyte cell number J:35020
abnormal myelopoiesis J:15222
abnormal nitric oxide homeostasis J:115459
abnormal osteoblast differentiation J:93577
abnormal placental labyrinth vasculature morphology J:113180
abnormal protein level J:129479
abnormal response to infection J:15222
abnormal skeleton morphology J:93577
abnormal skeleton physiology J:93577
abnormal trabecular bone morphology J:93577
abnormal tumor necrosis factor level J:35020, J:51636, J:107077
abnormal type IV hypersensitivity reaction J:35510
absent erythroid progenitor cell J:15222
alveolar process atrophy J:147935
anemia J:15222
cachexia J:15222
cecum inflammation J:35020
chronic inflammation J:15222
colitis J:68476
decreased airway responsiveness J:62283, J:115459
decreased bone mineral content J:93577
decreased bone strength J:93577
decreased bone trabecula number J:93577
decreased circulating cholesterol level J:129479
decreased circulating creatinine level J:93577
decreased circulating insulin level J:129479
decreased circulating iron level J:15222
decreased compact bone mass J:93577
decreased erythrocyte cell number J:15222
decreased hemoglobin content J:15222
decreased incidence of tumors by UV induction J:125760
decreased length of allograft survival J:44346
decreased physiological sensitivity to xenobiotic J:115459
decreased spleen iron level J:15222
decreased spleen red pulp amount J:15222
decreased T cell proliferation J:125760
decreased trabecular bone mass J:93577
decreased trabecular bone thickness J:93577
decreased tumor incidence J:125760
enhanced wound healing J:117053
hypochromic anemia J:15222
normal immune system phenotype J:15222, J:107077
increased CD4-positive, alpha beta T cell number J:35020
increased circulating cholesterol level J:129479
increased fatty acid level J:129479
increased granulocyte number J:15222, J:35020
increased hepatocyte apoptosis J:110238
increased IgE level J:62283
increased IgG1 level J:62283
increased IgG2a level J:62283
increased insulin sensitivity J:129479
increased interferon-gamma secretion J:15222
increased intestinal adenocarcinoma incidence J:68476
increased large intestine adenocarcinoma incidence J:35020
increased leukotriene level J:62283
increased liver triglyceride level J:129479
increased myocardial infarction size J:70292
increased placental labyrinth size J:113180
increased susceptibility to parasitic infection J:123927
increased susceptibility to type IV hypersensitivity reaction J:51636
increased thermal nociceptive threshold J:119039
increased thymus weight J:107077
intestinal inflammation J:15222, J:35020, J:107077
large intestinal inflammation J:35020
microcytic anemia J:15222
postnatal growth retardation J:15222
premature death J:15222
short femur J:93577
small intestinal inflammation J:35020
thymus hyperplasia J:107077
Il10tm1Cgn/Il10tm1Cgn
involves: 129P2/OlaHsd * C57BL/6 * DBA/1
colitis J:84100
decreased body weight J:84100
Il10tm1Flv/Il10tm1Flv
involves: 129S6/SvEvTac * C57BL/6
no abnormal phenotype detected J:116616
Il10tm1Hbo/Il10tm1Hbo
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6
no abnormal phenotype detected J:179239
Il10tm1Mhry/Il10tm1Mhry
involves: 129P2/OlaHsd * C57BL/6
intestinal inflammation J:117628
Il10tm1Roer/Il10tm1Roer
involves: 129P2/OlaHsd * C57BL/6
no abnormal phenotype detected J:94537
Il10tm1Roer/Il10tm1Roer
Foxp3tm4(YFP/icre)Ayr/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal regulatory T cell physiology J:134513
abnormal type IV hypersensitivity reaction J:134513
colitis J:134513
decreased interleukin-10 secretion J:134513
lung inflammation J:134513
Il10tm1Roer/Il10tm1Roer
Tg(Cd4-cre)1Cwi/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2
abnormal cytokine secretion J:94537
abnormal hypersensitivity reaction J:94537
abnormal intestinal mucosa morphology J:94537
abnormal lymph node morphology J:94537
crypts of Lieberkuhn abscesses J:94537
increased sensitivity to induced morbidity/mortality J:94537
increased susceptibility to parasitic infection J:94537
intestinal inflammation J:94537
intestinal ulcer J:94537
liver inflammation J:94537
peritoneal inflammation J:94537
rectal prolapse J:94537
Il10tm2Hbo/Il10tm2Hbo
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6
no abnormal phenotype detected J:179239
Il10tm2Roer/Il10tm2Roer
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6
abnormal cytokine secretion J:117122
abnormal inflammatory response J:117122
increased susceptibility to endotoxin shock J:117122
Il10tm2Roer/Il10tm2Roer
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2
abnormal inflammatory response J:117122
increased susceptibility to endotoxin shock J:117122
Tg(IL2-Il10)1Kro/0
involves: C3H * C57BL/6
abnormal cytokine secretion J:41588
decreased susceptibility to parasitic infection J:41588
increased susceptibility to bacterial infection J:80569
Tg(INS-Il10)#Sar/0
involves: BALB/c
abnormal exocrine pancreas morphology J:107927
abnormal pancreas physiology J:107927
abnormal vascular endothelial cell morphology J:107927
pancreas inflammation J:107927
periinsulitis J:107927

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/09/2019
MGI 6.14
The Jackson Laboratory