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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ighm
immunoglobulin heavy constant mu
MGI:96448
98 phenotypes from 12 alleles in 18 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal B cell differentiation J:157575
abnormal plasma cell differentiation J:157575
decreased B cell number J:157575
decreased B cell proliferation J:157575
decreased B-1 B cell number J:157575
decreased follicular B cell number J:157575
decreased IgA level J:157575
decreased IgG1 level J:157575
decreased IgG2a level J:157575
decreased IgG3 level J:157575
decreased IgG level J:157575
decreased IgM level J:157575
decreased marginal zone B cell number J:157575
decreased mature B cell number J:157575
decreased Peyer's patch number J:157575
decreased pre-B cell number J:157575
decreased transitional stage B cell number J:157575
normal immune system phenotype J:157575
increased B cell number J:157575
increased B cell proliferation J:157575
increased plasma cell number J:157575
increased pro-B cell number J:157575
small lymph nodes J:157575
small Peyer's patches J:157575
Ighmtm1.1Aak/Ighmtm1.1Aak
involves: 129S2/SvPas * C57BL/6 		abnormal class switch recombination J:171251
decreased B cell number J:171251
decreased pre-B cell number J:171251
normal immune system phenotype J:171251
increased pro-B cell number J:171251
Ighmtm1Bhe/Ighmtm1Bhe
C.Cg-Ighmtm1Bhe 		abnormal complement pathway J:177421
abnormal immune serum protein physiology J:177421
impaired complement classical pathway J:177421
Ighmtm1Cgn/Ighm+
involves: 129S2/SvPas * C57BL/6 		arrested B cell differentiation J:70398
Ighmtm1Cgn/Ighm+
NOD.129S2-Ighmtm1Cgn 		increased susceptibility to autoimmune diabetes J:37287
Ighmtm1Cgn/Ighmtm1Cgn
B6.129S2-Ighmtm1Cgn 		abnormal CD8 positive, alpha-beta intraepithelial T cell morphology J:126867
abnormal intestinal epithelium morphology J:126867
Ighmtm1Cgn/Ighmtm1Cgn
B6.129S2-Ighmtm1Cgn/J 		abnormal cardiovascular system physiology J:182612
abnormal compact bone morphology J:145330
abnormal cytokine secretion J:118565
abnormal humoral immune response J:119584
abnormal respiratory system physiology J:125656
abnormal spleen morphology J:73100
abnormal trabecular bone morphology J:145330
arrested B cell differentiation J:119584
decreased bone mineral density J:145330
decreased CD4-positive, alpha-beta T cell number J:73100, J:118565
decreased CD8-positive, alpha-beta T cell number J:73100
decreased compact bone thickness J:145330
decreased compact bone volume J:145330
decreased dendritic cell number J:73100
decreased IgE level J:125656
decreased IgG1 level J:125656
decreased IgG level J:119584, J:125656
decreased immunoglobulin level J:119584
decreased spleen weight J:73100
decreased susceptibility to injury J:182612
decreased trabecular bone thickness J:145330
normal immune system phenotype J:73100, J:118565
increased susceptibility to parasitic infection J:74568
Ighmtm1Cgn/Ighmtm1Cgn
involves: 129S2/SvPas 		abnormal antigen presentation J:112160
abnormal CD4-positive, alpha-beta T cell physiology J:112160
abnormal metallophilic macrophage morphology J:88620
abnormal spleen marginal sinus morphology J:88620
abnormal spleen marginal zone macrophage morphology J:88620
absent follicular dendritic cells J:88620
absent mature B cells J:118453
arrested B cell differentiation J:118453
decreased IgA level J:157450
decreased IgG level J:157450
decreased susceptibility to type IV hypersensitivity reaction J:112160
decreased T cell proliferation J:112160
increased osteoclast cell number J:157619
increased susceptibility to induced arthritis J:157619
increased susceptibility to parasitic infection J:163761
Ighmtm1Cgn/Ighmtm1Cgn
involves: 129S2/SvPas * C57BL/6 		abnormal B cell differentiation J:64298, J:70398
abnormal lymphatic vessel morphology J:119344
abnormal respiratory system physiology J:119344
abnormal response to infection J:119344
absent immature B cells J:64298
absent mature B cells J:64298
arrested B cell differentiation J:64298
decreased IgM level J:64298
normal immune system phenotype J:113083
normal respiratory system phenotype J:119344
Ighmtm1Cgn/Ighmtm1Cgn
NOD.129S2-Ighmtm1Cgn 		decreased susceptibility to autoimmune diabetes J:37287
Ighmtm1Cgn/Ighmtm1Cgn
NOD.129S2-Ighmtm1Cgn/DvsJ 		abnormal T cell number J:80859
abnormal T cell proliferation J:80859
absent B cells J:80859
decreased spleen B cell follicle number J:80859
decreased susceptibility to autoimmune diabetes J:80859
Ighmtm1Cgn/Ighmtm1Cgn
NODCaj.129S2-Ighmtm1Cgn 		insulitis J:93190
Ighmtm1Che/Ighmtm1Che
involves: 129 * C57BL/6 		increased susceptibility to parasitic infection J:74568
Ighmtm1Che/Ighmtm1Che
involves: 129S4/SvJae * C57BL/6 		abnormal B cell physiology J:47425
abnormal follicular dendritic cell antigen presentation J:47425
abnormal humoral immune response J:47425
abnormal immune system physiology J:47425
abnormal metallophilic macrophage morphology J:125338
abnormal spleen B cell follicle morphology J:125338
abnormal spleen germinal center morphology J:47425
abnormal spleen marginal zone morphology J:125338
abnormal spleen morphology J:125338
abnormal spleen periarteriolar lymphoid sheath morphology J:125338
abnormal spleen white pulp morphology J:125338
decreased IgG1 level J:47425
decreased IgG2b level J:47425
decreased IgM level J:47425
increased B-1 B cell number J:47425
increased IgA level J:47425
increased IgG2a level J:47425
increased IgG3 level J:47425
Ighmtm1Fbb/Ighmtm1Fbb
involves: BALB/cJ 		normal immune system phenotype J:57600
increased susceptibility to Riboviria infection J:57600
Ighmtm1Msn/Ighm+
involves: 129S/SvEv 		decreased IgM level J:49405
Ighmtm1Msn/Ighmtm1Msn
B6.129S-Ighmtm1Msn 		abnormal B-1a B cell morphology J:80656
abnormal splenic cell ratio J:80656
decreased follicular B cell number J:80656
decreased IgM level J:80656
increased marginal zone B cell number J:80656
Ighmtm1Msn/Ighmtm1Msn
involves: 129S/SvEv 		abnormal B-1a B cell morphology J:49405
abnormal immature B cell morphology J:49405
abnormal mature B cell morphology J:49405
decreased IgG1 level J:49405
decreased IgM level J:49405
increased IgG3 level J:49405
Ighmtm1Msn/Ighmtm1Msn
involves: 129S/SvEv * C57BL/6 		increased anti-double stranded DNA antibody level J:111817
increased autoantibody level J:111817
kidney inflammation J:111817
Ighmtm1Sls/Ighmtm1Sls
Not Specified 		abnormal class switch recombination J:99465
decreased IgG1 level J:99465
decreased IgG2b level J:99465
decreased IgG3 level J:99465
decreased IgG level J:99465
increased IgM level J:99465
Ighmtm2.1Bgmn/Ighmtm2.1Bgmn
involves: 129/Sv * C57BL/6 * CBA 		abnormal immune system physiology J:118453
absent mature B cells J:118453
arrested B cell differentiation J:118453
decreased immunoglobulin level J:118453
Ighmtm2.1Che/Ighmtm2.1Che
involves: 129S4/SvJae * C57BL/6 		no abnormal phenotype detected J:59960
Ighmtm3Bgmn/Ighmtm3Bgmn
involves: 129 		abnormal B cell activation J:131633
decreased B cell proliferation J:131633
decreased IgM level J:131633
decreased immature B cell number J:131633
decreased mature B cell number J:131633
increased B-1 B cell number J:131633
Ighmtm4Bgmn/Ighmtm4Bgmn
involves: 129 		abnormal B cell activation J:131633
decreased B cell proliferation J:131633
decreased IgM level J:131633
decreased immature B cell number J:131633
decreased mature B cell number J:131633
increased B-1 B cell number J:131633
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory