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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Hmox1
heme oxygenase 1
MGI:96163
88 phenotypes from 6 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Hmox1tm1.1Gkl/Hmox1tm1.1Gkl
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129 * 129P2/OlaHsd * BALB/cJ * C57BL/6
decreased interferon-beta secretion J:148498
decreased susceptibility to bacterial infection induced morbidity/mortality J:148498
decreased susceptibility to viral infection J:148498
increased B cell number J:148498
increased CD4-positive, alpha beta T cell number J:148498
increased CD8-positive, alpha-beta T cell number J:148498
increased circulating tumor necrosis factor level J:148498
increased granulocyte number J:148498
increased interferon-gamma secretion J:148498
increased macrophage cell number J:148498
increased splenocyte proliferation J:148498
increased susceptibility to experimental autoimmune encephalomyelitis J:148498
Hmox1tm1.1Hes/Hmox1tm1.1Hes
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N
abnormal cellular respiration J:214639
abnormal metabolism J:214639
abnormal mitochondrial physiology J:214639
abnormal redox activity J:214639
decreased circulating free fatty acid level J:214639
decreased fat cell size J:214639
decreased inflammatory response J:214639
decreased interleukin-1 beta secretion J:214639
decreased interleukin-6 secretion J:214639
decreased susceptibility to hepatic steatosis J:214639
decreased susceptibility to weight gain J:214639
decreased tumor necrosis factor secretion J:214639
improved glucose tolerance J:214639
increased energy expenditure J:214639
increased insulin sensitivity J:214639
Hmox1tm1.1Hes/Hmox1tm1.1Hes
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA
abnormal cellular respiration J:214639
abnormal metabolism J:214639
abnormal mitochondrial physiology J:214639
abnormal redox activity J:214639
decreased circulating alanine transaminase level J:214639
decreased circulating aspartate transaminase level J:214639
decreased susceptibility to hepatic steatosis J:214639
increased insulin sensitivity J:214639
Hmox1tm1.1Hes/Hmox1tm1.1Hes
Tg(Ckmm-cre)5Khn/0
involves: C57BL/6J * C57BL/6N * FVB/N
normal homeostasis/metabolism phenotype J:214639
Hmox1tm1.1Hes/Hmox1tm1.1Hes
Tg(Fabp4-cre)1Rev/0
involves: C57BL/6J * C57BL/6N
normal homeostasis/metabolism phenotype J:214639
Hmox1tm1.1Hes/Hmox1tm1.1Hes
Tg(Ins2-cre)25Mgn/0
involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA
normal homeostasis/metabolism phenotype J:214639
Hmox1tm1.2Gkl/Hmox1tm1.2Gkl
involves: 129 * BALB/cJ * C57BL/6
enlarged spleen J:148498
increased inflammatory response J:148498
liver inflammation J:148498
postnatal lethality, incomplete penetrance J:148498
premature death J:148498
Hmox1tm1Mlee/Hmox1tm1Mlee
B6.129S2-Hmox1tm1Mlee
abnormal artery morphology J:106600
abnormal vascular smooth muscle physiology J:106600
Hmox1tm1Mlee/Hmox1tm1Mlee
involves: 129S2/SvPas * BALB/c
abnormal thrombosis J:54684
altered response to myocardial infarction J:54684
cardiac fibrosis J:54684
cerebral edema J:153083
dilated heart right ventricle J:54684
increased cardiomyocyte apoptosis J:54684
increased circulating alanine transaminase level J:153083
increased heart right ventricle weight J:54684
increased susceptibility to parasitic infection J:153083
increased susceptibility to parasitic infection induced morbidity/mortality J:153083
liver failure J:153083
myocardium necrosis J:54684
oxidative stress J:54684
perinatal lethality, incomplete penetrance J:54684
postnatal lethality, incomplete penetrance J:54684
Hmox1tm1Poss/Hmox1tm1Poss
involves: 129S2/SvPas * C57BL/6
abnormal iron homeostasis J:79254
abnormal leukocyte cell number J:79254
abnormal lymph node cell ratio J:79254
abnormal splenic cell ratio J:79254
anisocytosis J:79254
cachexia J:79254
chronic inflammation J:79254
decreased body size J:79254
decreased circulating iron level J:79254
decreased erythrocyte cell number J:79254
decreased hematocrit J:79254
decreased hemoglobin content J:79254
decreased mean corpuscular volume J:79254
enlarged lymph nodes J:79254
enlarged spleen J:79254
extramedullary hematopoiesis J:79254
glomerular crescent J:79254
glomerulonephritis J:79254
glomerulosclerosis J:79254
hypoactivity J:79254
increased blood urea nitrogen level J:62437
increased circulating ferritin level J:79254
increased renal tubule apoptosis J:62437
infertility J:79254
kidney failure J:62437
liver fibrosis J:79254
liver inflammation J:79254
lung inflammation J:79254
microcytic anemia J:79254
oxidative stress J:79254
poor grooming J:79254
postnatal lethality, incomplete penetrance J:79254
premature death J:79254
proximal convoluted tubule brush border loss J:62437
renal cast J:62437
renal tubular necrosis J:62437
small testis J:79254
spleen hyperplasia J:79254
Hmox1tm1Ysh/Hmox1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal cardiac muscle contractility J:95461
abnormal cardiovascular system physiology J:95461
increased myocardial infarction size J:95461
myocardium necrosis J:95461
Hmox1tm1Ysh/Hmox1tm1Ysh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
prenatal lethality, complete penetrance J:95461

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory