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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nrg1
neuregulin 1
MGI:96083
99 phenotypes from 16 alleles in 22 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nrg1m1Yzcm/Nrg1+
C57BL/6J-Nrg1m1Yzcm 		mydriasis J:175524
Nrg1m1Yzcm/Nrg1m1Yzcm
C57BL/6J-Nrg1m1Yzcm 		abnormal iris morphology J:175524
mydriasis J:175524
preweaning lethality, incomplete penetrance J:175524
Nrg1tm1Cbm/Nrg1+
involves: 129P2/OlaHsd 		abnormal cardiovascular system physiology J:100313
abnormal myelination J:90038
abnormal nerve conduction J:90038
decreased heart weight J:100313
decreased left ventricle systolic pressure J:100313
decreased ventricle muscle contractility J:100313
increased susceptibility to xenobiotic induced morbidity/mortality J:100313
weight loss J:100313
Nrg1tm1Cbm/Nrg1tm1Cbm
involves: 129P2/OlaHsd 		abnormal heart ventricle morphology J:119151
abnormal myocardium layer morphology J:119151
abnormal neural crest cell migration J:48515
abnormal sympathetic ganglion morphology J:48515
Nrg1tm1Cbm/Nrg1tm1Cbm
involves: 129P2/OlaHsd * C57BL/6 		abnormal cranial ganglia morphology J:29971
abnormal cranial nerve morphology J:29971
abnormal mandibular nerve innervation pattern J:29971
abnormal superior vagus ganglion morphology J:29971
absent oligodendrocytes J:52282
absent trigeminal nerve J:29971
decreased radial glial cell number J:82745
decreased Schwann cell precursor number J:29971
embryonic lethality during organogenesis, complete penetrance J:29971
enlarged heart J:29971
enlarged pericardium J:29971
failure of atrioventricular cushion closure J:29971
irregular heartbeat J:29971
small nodose ganglion J:29971
small petrosal ganglion J:29971
trabecula carnea hypoplasia J:29971
Nrg1tm1Cbm/Nrg1tm3Cbm
Isl1tm1(cre)Tmj/Isl1+
involves: 129P2/OlaHsd * 129X1/SvJ 		abnormal muscle spindle morphology J:80793
abnormal proprioceptive neuron morphology J:80793
decreased Schwann cell number J:80793
Nrg1tm1Fej/Nrg1tm1Fej
involves: 129P2/OlaHsd * C57BL/6 * FVB 		abnormal mammary gland growth during pregnancy J:81107
Nrg1tm1Fej/Nrg1tm1Fej
Emx1tm1(cre)Krj/?
involves: 129P2/OlaHsd * 129S2/SvPas 		normal nervous system phenotype J:145464
Nrg1tm1Fej/Nrg1tm1Fej
Neurod6tm1(cre)Kan/?
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		normal nervous system phenotype J:145464
Nrg1tm1Fej/Nrg1tm1Fej
Tg(Camk2a-cre)#Kln/?
involves: 129P2/OlaHsd * CBA/J 		normal nervous system phenotype J:145464
Nrg1tm1Fej/Nrg1tm1Fej
Tg(Nes-cre)1Kln/?
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal Schwann cell morphology J:145464
normal nervous system phenotype J:145464
Nrg1tm1Gne/Nrg1+
B6.129S2-Nrg1tm1Gne 		abnormal excitatory postsynaptic currents J:182690
enhanced long-term potentiation J:182690
Nrg1tm1Gne/Nrg1tm1Gne
either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6J) 		abnormal cranial ganglia morphology J:45302
abnormal dorsal root ganglion morphology J:45302
abnormal hypoglossal nerve morphology J:45302
abnormal petrosal ganglion morphology J:45302
abnormal trigeminal nerve morphology J:45302
abnormal ventral spinal root morphology J:45302
absent mandibular nerve J:45302
absent trabeculae carneae J:45302
embryonic lethality during organogenesis, complete penetrance J:45302
enlarged heart J:45302
irregular heartbeat J:45302
poor circulation J:45302
small nodose ganglion J:45302
thin ventricular wall J:45302
Nrg1tm1Gne/Nrg1tm1Gne
involves: 129S2/SvPas * C57BL/6J 		abnormal locomotor coordination J:62377
hyperactivity J:62377
Nrg1tm1Leth/Nrg1+
involves: 129S1/Sv * C57BL/6 		abnormal endplate potential J:39800
abnormal miniature endplate potential J:39800
abnormal neuromuscular synapse morphology J:39800
abnormal PNS synaptic transmission J:39800
Nrg1tm1Leth/Nrg1tm1Leth
involves: 129S1/Sv * C57BL/6 		abnormal atrioventricular cushion morphology J:33038
abnormal cranial ganglia morphology J:33038
abnormal glossopharyngeal nerve morphology J:33038
abnormal mandibular nerve branching J:33038
abnormal trigeminal ganglion morphology J:33038
abnormal vagus nerve morphology J:33038
decreased cardiac muscle contractility J:33038
decreased cardiac output J:33038
decreased heart rate J:33038
dilated heart ventricle J:33038
embryonic growth arrest J:33038
embryonic lethality during organogenesis, complete penetrance J:33038
trabecula carnea hypoplasia J:33038
Nrg1tm1Leth/Nrg1tm1Leth
Not Specified 		normal nervous system phenotype J:43309
Nrg1tm1Lex/Nrg1tm1Lex
involves: 129S5/SvEvBrd * C57BL/6J 		preweaning lethality, complete penetrance J:103485
Nrg1tm1Lwr/Nrg1+
involves: 129 		abnormal myelination J:90038
Nrg1tm1Lwr/Nrg1tm1Lwr
129/Sv-Nrg1tm1Lwr 		abnormal cranial ganglia morphology J:60159
abnormal cranial nerve morphology J:60159
abnormal intercostal muscle morphology J:60159
abnormal motor neuron innervation pattern J:60159
abnormal phrenic nerve morphology J:60159
abnormal sensory neuron innervation pattern J:60159
abnormal spinal nerve morphology J:60159
centrally nucleated skeletal muscle fibers J:60159
cyanosis J:60159
decreased motor neuron number J:60159
decreased Schwann cell number J:60159
decreased sensory neuron number J:60159
defasiculated phrenic nerve J:60159
limp posture J:60159
neonatal lethality, complete penetrance J:60159
no spontaneous movement J:60159
respiratory failure J:60159
small dorsal root ganglion J:60159
thin diaphragm muscle J:60159
unresponsive to tactile stimuli J:60159
Nrg1tm1Lwr/Nrg1tm1Lwr
involves: 129 		absent Schwann cells J:80793
normal muscle phenotype J:80793
Nrg1tm1Sabe/Nrg1tm1Sabe
Tg(Amh-cre/ERT)#Sabe/0
B6JJcl.Cg-Nrg1tm1Sabe Tg(Amh-cre/ERT)#Sabe 		abnormal male germ cell apoptosis J:175448
abnormal male reproductive system physiology J:175448
abnormal seminiferous tubule morphology J:175448
abnormal spermatogenesis J:175448
azoospermia J:175448
decreased testis weight J:175448
small testis J:175448
Nrg1tm1Zhou/Nrg1tm1Zhou
involves: 129S1/Sv * C57BL/6 		abnormal cranial ganglia morphology J:50592
abnormal mandibular nerve branching J:50592
abnormal trigeminal ganglion morphology J:50592
abnormal trigeminal nerve morphology J:50592
normal cardiovascular system phenotype J:50592
decreased heart rate J:50592
embryonic lethality during organogenesis, complete penetrance J:50592
irregular heartbeat J:50592
small nodose ganglion J:50592
small petrosal ganglion J:50592
trabecula carnea hypoplasia J:50592
Nrg1tm2Cbm/Nrg1+
involves: 129P2/OlaHsd 		normal nervous system phenotype J:145464
Nrg1tm2Cbm/Nrg1tm2Cbm
involves: 129P2/OlaHsd 		abnormal neural crest cell migration J:48515
abnormal sympathetic ganglion morphology J:48515
decreased Schwann cell number J:43309
Nrg1tm2Cbm/Nrg1tm2Cbm
involves: 129P2/OlaHsd * C57BL/6 		abnormal cranial ganglia morphology J:29971
abnormal cranial nerve morphology J:29971
abnormal mandibular nerve innervation pattern J:29971
abnormal superior vagus ganglion morphology J:29971
absent trigeminal nerve J:29971
decreased Schwann cell precursor number J:29971
embryonic lethality during organogenesis, complete penetrance J:29971
enlarged heart J:29971
enlarged pericardium J:29971
failure of atrioventricular cushion closure J:29971
irregular heartbeat J:29971
small nodose ganglion J:29971
small petrosal ganglion J:29971
trabecula carnea hypoplasia J:29971
Nrg1tm2Zhou/Nrg1+
involves: 129S4/SvJae * C57BL/6 		abnormal prepulse inhibition J:81106
hyperactivity J:81106
Nrg1tm2Zhou/Nrg1tm2Zhou
involves: 129S4/SvJae * C57BL/6 		abnormal heart morphology J:81106
embryonic lethality during organogenesis, complete penetrance J:81106
Nrg1tm3Cbm/Nrg1tm3Cbm
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal muscle spindle morphology J:199150
decreased muscle spindle number J:199150
impaired coordination J:199150
Nrg1tm4.1Cbm/Nrg1+
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 		decreased muscle spindle number J:199150
Nrg1tm4Cbm/Nrg1tm4.1Cbm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * CBA/J 		abnormal gait J:199150
abnormal muscle spindle morphology J:199150
decreased muscle spindle number J:199150
impaired coordination J:199150
normal nervous system phenotype J:199150
Tg(Thy1-Nrg1*I)1Kan/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal muscle spindle morphology J:199150
abnormal proprioceptive neuron morphology J:199150
increased muscle spindle number J:199150
Tg(Thy1-Nrg1*I)1Kan/0
Not Specified 		hypermyelination J:90038, J:145464
Tg(Thy1-Nrg1*III)1Kan/0
Not Specified 		abnormal myelination J:145464
normal nervous system phenotype J:90038
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory