149 phenotypes from 21 alleles in 20 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Httem1(IMPC)H/Htt+ C57BL/6NTac-Httem1(IMPC)H/H	increased grip strength	J:211773
Httem1(IMPC)H/Httem1(IMPC)H C57BL/6NTac-Httem1(IMPC)H/H	embryonic lethality prior to organogenesis	J:211773
	preweaning lethality, complete penetrance	J:211773
Htttm1.1Pfs/Htt+ involves: 129S4/SvJae * C57BL/6	decreased brain size	J:54906
	increased aggression towards mice	J:54906
Htttm1.1Tna/Htt+ involves: 129P2/OlaHsd * C57BL/6J	astrocytosis	J:76017
Htttm1.1Tna/Htttm1.1Tna involves: 129P2/OlaHsd * C57BL/6J	astrocytosis	J:76017
Htttm1Detl/Htt+ involves: 129P2/OlaHsd * C57BL/6J	normal behavior/neurological phenotype	J:67074
	decreased body size	J:67074
	decreased locomotor activity	J:67074
	normal homeostasis/metabolism phenotype	J:67074
	impaired limb coordination	J:67074
	normal nervous system phenotype	J:67074
Htttm1Detl/Htttm1Detl involves: 129P2/OlaHsd * C57BL/6J	normal behavior/neurological phenotype	J:67074
	decreased body size	J:67074
	normal homeostasis/metabolism phenotype	J:67074
	impaired limb coordination	J:67074
	normal nervous system phenotype	J:67074
	neuron degeneration	J:67074
	tonic-clonic seizures	J:67074
Htttm1Hay/Htt+ involves: C57BL/6J	abnormal globus pallidus morphology	J:25941
	abnormal learning/memory/conditioning	J:25941
	abnormal subthalamic nucleus morphology	J:25941
	hyperactivity	J:25941
	hyperresponsive	J:25941
Htttm1Hay/Htttm1Hay involves: C57BL/6J	abnormal extraembryonic tissue morphology	J:25941
	abnormal gastrulation	J:25941
	decreased embryo size	J:25941
	embryonic growth arrest	J:25941
	embryonic lethality between implantation and placentation, incomplete penetrance	J:25941
	embryonic lethality during organogenesis, complete penetrance	J:25941
Htttm1Mem/Htt+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1	no abnormal phenotype detected	J:27183
Htttm1Mem/Htttm1Mem involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1	abnormal developmental patterning	J:27183
	abnormal ectoderm development	J:27183
	abnormal embryonic tissue morphology	J:27183
	abnormal extraembryonic endoderm formation	J:27183
	abnormal extraembryonic mesoderm development	J:27183
	abnormal extraembryonic tissue morphology	J:27183
	absent primitive node	J:27183
	decreased embryo size	J:27183
	embryonic lethality between somite formation and embryo turning, complete penetrance	J:27183
	embryonic-extraembryonic boundary constriction	J:27183
	increased ectoderm apoptosis	J:27183
Htttm1Mem/Htttm3Mem involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1	no abnormal phenotype detected	J:44391
Htttm1Mem/Htttm6Mem involves: 129S1/Sv * 129X1/SvJ * Swiss Webster	abnormal motor capabilities/coordination/movement	J:72915
	decreased body size	J:72915
	enlarged lateral ventricles	J:72915
Htttm1Mem/Htttm6Mem Tg(CAG-cre/Esr1*)5Amc/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * Swiss Webster	abnormal cerebellum lobule morphology	J:260244
	abnormal cerebral cortex morphology	J:260244
	abnormal gait	J:260244
	abnormal lateral ganglionic eminence morphology	J:260244
	abnormal nervous system development	J:260244
	abnormal oligodendrocyte morphology	J:260244
	abnormal primary motor cortex morphology	J:260244
	astrocytosis	J:260244
	axon degeneration	J:260244
	normal behavior/neurological phenotype	J:260244
	decreased body weight	J:260244
	dysmyelination	J:260244
	ectopic neuron	J:260244
	environmentally induced seizures	J:260244
	gliosis	J:260244
	hyperactivity	J:260244
	impaired coordination	J:260244
	limb grasping	J:260244
	lordokyphosis	J:260244
	muscular atrophy	J:260244
	neurodegeneration	J:260244
	neuronal cytoplasmic inclusions	J:260244
	short stride length	J:260244
	straub tail	J:260244
Htttm1Mem/Htttm7Mem involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1	abnormal blood vessel morphology	J:44391
	abnormal brain ventricle morphology	J:44391
	abnormal cerebellum development	J:44391
	abnormal cerebral aqueduct morphology	J:44391
	abnormal ear position	J:44391
	abnormal ear shape	J:44391
	abnormal embryonic/fetal subventricular zone morphology	J:44391
	abnormal forebrain morphology	J:44391
	abnormal head morphology	J:44391
	abnormal hippocampus morphology	J:44391
	abnormal midbrain morphology	J:44391
	abnormal nervous system tract morphology	J:44391
	abnormal olfactory bulb morphology	J:44391
	abnormal striatum morphology	J:44391
	abnormal telencephalon morphology	J:44391
	abnormal thalamus morphology	J:44391
	absent hippocampal fimbria	J:44391
	dilated lateral ventricle	J:44391
	domed cranium	J:44391
	exencephaly	J:44391
	lethality throughout fetal growth and development, incomplete penetrance	J:44391
	perinatal lethality, complete penetrance	J:44391
	thick skin	J:44391
Htttm1Mfc/Htttm1Mfc involves: 129S1/Sv * C57BL/6	abnormal brain morphology	J:85298
	abnormal gait	J:85298
	abnormal locomotor activation	J:141673
	abnormal motor capabilities/coordination/movement	J:85298
	abnormal olfactory system morphology	J:85298
	decreased body weight	J:141673
	decreased locomotor activity	J:85298, J:141673
	decreased vertical activity	J:141673
	hyperactivity	J:141673
	increased grooming behavior	J:141673
	increased locomotor activity	J:85298
	increased vertical activity	J:85298
	short stride length	J:85298
Htttm1Szi/Htttm1Szi either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * MF1)	abnormal amniotic cavity morphology	J:29267
	abnormal egg cylinder morphology	J:29267
	abnormal embryonic tissue morphology	J:29267
	abnormal extraembryonic tissue morphology	J:29267
	abnormal Reichert's membrane morphology	J:29267
	abnormal visceral endoderm morphology	J:29267
	disorganized embryonic tissue	J:29267
	disorganized extraembryonic tissue	J:29267
	embryonic growth arrest	J:29267
	embryonic lethality, complete penetrance	J:29267
	increased embryonic epiblast cell apoptosis	J:29267
	increased embryonic tissue cell apoptosis	J:29267
	increased Reichert's membrane thickness	J:29267
	small amniotic cavity	J:29267
Htttm1Szi/Htttm2Szi Tg(Camk2a-cre)1Szi/0 involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA	abnormal seminiferous tubule morphology	J:65520
	astrocytosis	J:65520
	decreased body size	J:65520
	decreased locomotor activity	J:65520
	gliosis	J:65520
	impaired coordination	J:65520
	limb grasping	J:65520
	neurodegeneration	J:65520
	oligozoospermia	J:65520
	premature death	J:65520
	reduced male fertility	J:65520
	small testis	J:65520
	tremors	J:65520
Htttm1Szi/Htttm2Szi Tg(Camk2a-cre)2Szi/0 involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA	abnormal brain internal capsule morphology	J:65520
	abnormal cerebral cortex morphology	J:65520
	abnormal seminiferous tubule morphology	J:65520
	abnormal striatum morphology	J:65520
	astrocytosis	J:65520
	decreased body size	J:65520
	decreased locomotor activity	J:65520
	gliosis	J:65520
	hydrocephaly	J:65520
	impaired coordination	J:65520
	limb grasping	J:65520
	neurodegeneration	J:65520
	oligozoospermia	J:65520
	premature death	J:65520
	reduced male fertility	J:65520
	small testis	J:65520
	tremors	J:65520
Htttm2.1Pfs/Htt+ involves: 129X1/SvJ * C57BL/6	decreased brain size	J:54906
	increased aggression towards mice	J:54906
Htttm2Detl/Htt+ B6J.129P2-Htttm2Detl	abnormal myelination	J:220868
	abnormal oligodendrocyte physiology	J:220868
	abnormal striatum morphology	J:220868
	brain atrophy	J:220868
	decreased myelin sheath thickness	J:220868
	decreased neocortex volume	J:220868
	decreased oligodendrocyte number	J:220868
	dysmyelination	J:220868
	impaired coordination	J:220868
	increased taurine level	J:220868
	microgliosis	J:220868
	neuronal intranuclear inclusions	J:220868
	weight loss	J:220868
Htttm2Detl/Htt+ involves: 129P2/OlaHsd * C57BL/6J	abnormal behavior	J:123681
	abnormal dorsal striatum morphology	J:123681
	abnormal gait	J:67074, J:123681
	abnormal motor capabilities/coordination/movement	J:67074
	abnormal motor coordination/balance	J:67074
	abnormal ventral striatum morphology	J:123681
	decreased body size	J:67074
	decreased locomotor activity	J:67074
	enhanced coordination	J:123681
	gliosis	J:67074
	normal homeostasis/metabolism phenotype	J:67074
	impaired balance	J:123681
	impaired limb coordination	J:67074
	limb grasping	J:67074
	normal nervous system phenotype	J:67074
	neuron degeneration	J:67074
	premature death	J:67074
	short stride length	J:123681
Htttm2Detl/Htttm2Detl involves: 129P2/OlaHsd * C57BL/6J	abnormal behavior	J:123681
	abnormal dorsal striatum morphology	J:123681
	abnormal gait	J:67074, J:123681
	abnormal motor capabilities/coordination/movement	J:67074, J:123681
	abnormal motor coordination/balance	J:67074
	abnormal neuron morphology	J:123681
	abnormal striatum morphology	J:123681
	abnormal ventral striatum morphology	J:123681
	decreased body size	J:67074
	decreased locomotor activity	J:67074, J:123681
	gliosis	J:67074
	normal homeostasis/metabolism phenotype	J:67074
	impaired balance	J:123681
	impaired coordination	J:123681
	impaired limb coordination	J:67074
	limb grasping	J:67074, J:123681
	normal nervous system phenotype	J:67074
	neuron degeneration	J:67074
	neuronal intranuclear inclusions	J:67074
	short stride length	J:123681
	tonic-clonic seizures	J:67074, J:123681
	tremors	J:123681
	weight loss	J:123681
Htttm2Mem/Htttm2Mem involves: 129S1/Sv * 129X1/SvJ * CD-1	normal nervous system phenotype	J:99425
Htttm3Mem/Htttm3Mem involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal nervous system phenotype	J:99425
Htttm3Mem/Htttm3Mem involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1	no abnormal phenotype detected	J:44391
Htttm4Mem/Htt+ involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal medium spiny neuron morphology	J:60937
	abnormal striatum morphology	J:60937
	neuronal intranuclear inclusions	J:60937
Htttm4Mem/Htttm4Mem involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal cerebral cortex morphology	J:111237
	abnormal medium spiny neuron morphology	J:60937
	abnormal nervous system physiology	J:99425
	abnormal striatum morphology	J:111237
	limb grasping	J:99425
	neuronal intranuclear inclusions	J:60937
Htttm4Szi/Htttm4Szi involves: 129S1/Sv	no abnormal phenotype detected	J:111323
Htttm4Szi/Htttm4Szi Tg(Hsp70-1-cre)1Arge/0 involves: 129S1/Sv * C57BL/6J * CBA	abnormal embryonic tissue morphology	J:111323
	absent somites	J:111323
	embryonic growth retardation	J:111323
	embryonic lethality between somite formation and embryo turning, complete penetrance	J:111323
Htttm4Szi/Htttm5Szi involves: 129S1/Sv	no abnormal phenotype detected	J:111323
Htttm4Szi/Htttm5Szi Tg(Hsp70-1-cre)1Arge/0 involves: 129S1/Sv * C57BL/6J * CBA	abnormal embryonic tissue morphology	J:111323
	absent somites	J:111323
	embryonic growth retardation	J:111323
	embryonic lethality between somite formation and embryo turning, complete penetrance	J:111323
Htttm5Detl/Htt+ involves: C57BL/6	abnormal gait	J:250587
	abnormal motor learning	J:250587
	abnormal striatum morphology	J:250587
	normal behavior/neurological phenotype	J:250587
	decreased grip strength	J:250587
	decreased locomotor activity	J:250587
	hunched posture	J:250587
	impaired coordination	J:250587
	increased thigmotaxis	J:250587
	long stride length	J:250587
	prenatal lethality, incomplete penetrance	J:250587
	weight loss	J:250587
Htttm5Detl/Htttm5Detl involves: C57BL/6	prenatal lethality, complete penetrance	J:250587
Htttm5Mem/Htt+ involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal medium spiny neuron morphology	J:60937
	abnormal striatum morphology	J:60937
	neuronal intranuclear inclusions	J:60937
Htttm5Mem/Htttm5Mem involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal behavior	J:99425
	abnormal cerebral cortex morphology	J:111237
	abnormal medium spiny neuron morphology	J:60937
	abnormal nervous system physiology	J:99425
	abnormal striatum morphology	J:60937, J:111237
	decreased locomotor activity	J:99425
	limb grasping	J:99425
	neuronal intranuclear inclusions	J:60937
	tremors	J:99425
Htttm5Mem/Htttm5Mem STOCK Htttm5Mem/J	abnormal motor coordination/balance	J:185262
	normal behavior/neurological phenotype	J:185262
	decreased body weight	J:185262
	normal nervous system phenotype	J:185262
Htttm6Mem/Htttm6Mem involves: 129S1/Sv * 129X1/SvJ * Swiss Webster	abnormal motor capabilities/coordination/movement	J:72915
	decreased body size	J:72915
Htttm6Mem/Htttm8Mem involves: 129S1/Sv * 129X1/SvJ * Swiss Webster	abnormal brain ventricle morphology	J:72915
	abnormal gait	J:72915
	abnormal locomotor coordination	J:72915
	abnormal motor capabilities/coordination/movement	J:72915
	bradykinesia	J:72915
	decreased body size	J:72915
	decreased body weight	J:72915
	enlarged lateral ventricles	J:72915
	enlarged third ventricle	J:72915
	increased susceptibility to malignant hyperthermia	J:72915
	limb grasping	J:72915
	normal nervous system phenotype	J:72915
	paralysis	J:72915
	premature death	J:72915
	seizures	J:72915
	tremors	J:72915
Htttm7Mem/Htttm7Mem involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1	abnormal anterior commissure morphology	J:44391
	abnormal cerebral aqueduct morphology	J:44391
	abnormal cerebral cortex morphology	J:44391
	abnormal cranium morphology	J:44391
	abnormal ear shape	J:44391
	abnormal forebrain morphology	J:44391
	abnormal lateral ventricle morphology	J:44391
	abnormal midbrain morphology	J:44391
	abnormal nervous system tract morphology	J:44391
	abnormal postnatal subventricular zone morphology	J:44391
	abnormal striatum morphology	J:44391
	abnormal telencephalon morphology	J:44391
	abnormal thalamus morphology	J:44391
	dilated lateral ventricle	J:44391
	enlarged cerebral aqueduct	J:44391
	lowered ear position	J:44391
	neonatal lethality, complete penetrance	J:44391
	perinatal lethality, incomplete penetrance	J:44391
	thick skin	J:44391
Htttm8Mem/Htttm8Mem involves: 129S1/Sv * 129X1/SvJ	preweaning lethality, complete penetrance	J:72915