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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
H2
histocompatibility-2, MHC
MGI:95894
83 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Airetm1.1Doi/Airetm1.1Doi
H2b/H2b
NOD.Cg-Airetm1.1Doi H2b/Doi
abnormal pancreas physiology J:107432
stomach inflammation J:107432
Apobec3Gt(XN450)Byg/Apobec3Rfv3-s
H2b/H2b
involves: A.BY * C57BL/6
abnormal immunoglobulin level J:138778
Apobec3Gt(XN450)Byg/Apobec3Rfv3-s
H2b/H2d
involves: BALB/c * C57BL/6
abnormal immunoglobulin level J:138778
increased sensitivity to induced morbidity/mortality J:138778
increased susceptibility to viral infection J:138778
Dh/Dh+
H2d/H2d
NZB.Cg-Dh
absent spleen J:12036
cryptorchism J:12036
decreased B cell proliferation J:12036
decreased IgG1 level J:12036
decreased IgG level J:12036
decreased IgM level J:12036
decreased lymphoma incidence J:12036
decreased susceptibility to graft versus host disease J:12036
glomerulonephritis J:12036
increased anti-erythrocyte antigen antibody level J:12036
increased anti-nuclear antigen antibody level J:12036
increased anti-single stranded DNA antibody level J:12036
increased autoantibody level J:12036
increased T cell proliferation J:12036
polyphalangy J:12036
reduced female fertility J:12036
reduced fertility J:12036
H2b/H2b
Itktm1Ljb/Itktm1Ljb
Tg(TcrAND)53Hed/?
involves: C3H/HeJ * C57BL/6 * C57BL/10
abnormal positive T cell selection J:123795
decreased CD4-positive, alpha beta T cell number J:123795
H2b/H2b
Nfkbidtm1Clay/Nfkbidtm1Clay
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraN15,TcrbN15)L2Elre/?
involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6
abnormal thymocyte activation J:132071
decreased interleukin-2 secretion J:132071
decreased T cell proliferation J:132071
H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
involves: 129P2/OlaHsd
decreased double-positive T cell number J:131357
decreased thymocyte number J:131357
spleen hypoplasia J:131357
H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
abnormal T cell differentiation J:131357
decreased thymocyte number J:131357
H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
abnormal T cell differentiation J:131357
H2b/H2b
Rag1tm1Mom/Rag1tm1Mom
Tg(Tcra19,Tcrb19)#Stl/0
involves: 129S7/SvEvBrd * C57BL/6
normal immune system phenotype J:19795
H2b/H2b
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraN15,TcrbN15)L2Elre/?
involves: 129S/SvEv * C57BL/6
abnormal cytotoxic T cell physiology J:133112
arrested T cell differentiation J:133112
decreased CD4-positive, alpha beta T cell number J:133112
increased CD8-positive, alpha-beta T cell number J:133112
increased T cell proliferation J:133112
H2b/H2b
Tcra/Tcrdtm1.1(Tcra)Rsky/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
abnormal negative T cell selection J:81564
abnormal T cell differentiation J:81564
H2b/H2b
Tcra/Tcrdtm1.1(Tcra)Rsky/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
abnormal negative T cell selection J:81564
abnormal T cell differentiation J:81564
H2b/H2b
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
abnormal double-negative T cell morphology J:131357
abnormal double-positive T cell morphology J:81564
abnormal negative T cell selection J:81564
abnormal T cell differentiation J:81564
decreased double-positive T cell number J:131357
decreased thymocyte number J:131357
H2b/H2d
Tg(Ins2-E3)1Dvs/0
involves: BALB/c * C57BL/6 * DBA/2J
increased length of allograft survival J:109763
H2b/H2d
Tg(TcraTcrb)1100Mjb/?
involves: BALB/c * C57BL/6
abnormal negative T cell selection J:133645
decreased CD8-positive, alpha-beta T cell number J:133645
small thymus J:133645
H2b/H2d
Themistm1Gasc/Themistm1Gasc
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * DBA/2
abnormal negative T cell selection J:151074
H2b/H2g7
Tg(TcraR28,TcrbR28)KRNDim/0
involves: C57BL/6 * NOD * SJL
rheumatoid arthritis J:36815
H2b/H2k
Itktm1Ljb/Itktm1Ljb
Tg(TcrAND)53Hed/?
involves: C3H/HeJ * C57BL/6 * C57BL/10
abnormal positive T cell selection J:123795
decreased CD4-positive, alpha beta T cell number J:123795
H2b/H2k
Tg(TcraTcrb)1100Mjb/?
involves: C57BL/6 * C57BL/10Sg * C57BR/c
abnormal negative T cell selection J:133645
decreased CD8-positive, alpha-beta T cell number J:133645
small thymus J:133645
H2b/H2s
Tg(TcraTcrb)1100Mjb/?
involves: A/WySn * C57BL/6 * C57BL/10Sg * Swiss
abnormal negative T cell selection J:133645
decreased CD8-positive, alpha-beta T cell number J:133645
small thymus J:133645
H2d/H2d
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraN15,TcrbN15)L2Elre/?
involves: 129S/SvEv * C57BL/6
arrested T cell differentiation J:133112
decreased CD4-positive, alpha beta T cell number J:133112
decreased CD8-positive, alpha-beta T cell number J:133112
H2d/H2d
Tcra/Tcrdtm1.1(Tcra)Rsky/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/0
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
abnormal T cell differentiation J:131357
decreased thymocyte number J:131357
H2d/H2d
Tg(TcraP1.5,TcrbP1.5)29Amsv/0
Trap1atm1.1Jvde/Y
involves: 129 * BALB/cJ * C57BL/10 * DBA/2
abnormal T cell clonal deletion J:180807
H2d/H2d
Trap1atm1.1Jvde/Y
involves: 129 * BALB/cJ * C57BL/10 * DBA/2
abnormal CD8-positive, alpha-beta T cell physiology J:180807
abnormal immune tolerance J:180807
decreased sensitivity to induced morbidity/mortality J:180807
normal reproductive system phenotype J:180807
tumor regression J:180807
H2d/H2d
Trap1atm1.1Jvde/Trap1atm1.1Jvde
involves: 129 * BALB/cJ * C57BL/10 * DBA/2
normal reproductive system phenotype J:180807
H2dlAb1-Ea/H2dlAb1-Ea
March1tm1.1Sish/March1tm1.1Sish
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
normal immune system phenotype J:157516
H2dlAb1-Ea/H2dlAb1-Ea
Psmb11tm1(Psmb8)Khog/Psmb11tm1(Psmb8)Khog
involves: 129S2/SvPas * C57BL/6
abnormal T cell differentiation J:196156
decreased CD8-positive, alpha-beta T cell number J:196156
H2dlAb1-Ea/H2dlAb1-Ea
Rag1tm1Mom/Rag1tm1Mom
Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
brain inflammation J:189816
H2dlAb1-Ea/H2dlAb1-Ea
Rag1tm1Mom/Rag1tm1Mom
Tg(HLA-DRA,HLA-DRB5*0101)loKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
brain inflammation J:189816
H2dlAb1-Ea/H2dlAb1-Ea
Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0
involves: 129S2/SvPas * C57BL/6
normal nervous system phenotype J:189816
H2dlAb1-Ea/H2dlAb1-Ea
Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * C57BL/6
abnormal axon morphology J:189816
abnormal cytokine secretion J:189816
abnormal motor capabilities/coordination/movement J:189816
axon degeneration J:189816
brain inflammation J:189816
CNS inflammation J:189816
increased CD4-positive, alpha beta T cell number J:189816
increased inflammatory response J:189816
increased interferon-gamma secretion J:189816
increased interleukin-17 secretion J:189816
increased susceptibility to experimental autoimmune encephalomyelitis J:189816
increased T-helper 1 cell number J:189816
increased T-helper 17 cell number J:189816
neuron degeneration J:189816
H2dlAb1-Ea/H2dlAb1-Ea
Tg(HLA-DRA,HLA-DRB5*0101)loKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * C57BL/6
brain inflammation J:189816
increased susceptibility to experimental autoimmune encephalomyelitis J:189816
H2dlAb1-Ea/H2dlAb1-Ea
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * C57BL/6
normal nervous system phenotype J:189816
H2g7/H2g7
Ins2tm1Jja/Ins2tm1Jja
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB * NOD
increased circulating glucose level J:111874
increased susceptibility to autoimmune diabetes J:111874
H2g7/H2g7
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
increased susceptibility to autoimmune diabetes J:111874
insulitis J:111874
H2g7/H2g7
Tg(Ins2-Vtcn1)#Xxz/0
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
involves: C57BL/6 * NOD * SJL
decreased interferon-gamma secretion J:177612
decreased interleukin-17 secretion J:177612
decreased regulatory T cell number J:177612
decreased susceptibility to autoimmune diabetes J:177612
H2g7/H2g7
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
B6.NOD-(D17Mit21-D17Mit10) Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
increased susceptibility to autoimmune diabetes J:167508
H2g7/H2g7
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
B6.Cg-H2g7 Tg(TcraBDC2.5,TcrbBDC2.5)1Doi
decreased susceptibility to autoimmune diabetes J:86926
H2g7/H2g7
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
decreased susceptibility to autoimmune diabetes J:111874
insulitis J:111874
H2g7/H2q
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
increased susceptibility to autoimmune diabetes J:111874
H2k/H2k
Tg(TcraTcrbAD10)1Hed/?
involves: C57BL/6 * SJL
increased CD4-positive, alpha beta T cell number J:124701
H2q/H2q
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
decreased susceptibility to autoimmune diabetes J:111874
normal digestive/alimentary phenotype J:111874
H2q/?
Ncf1m1J/Ncf1m1J
B6.Cg-Ncf1m1J H2q
decreased susceptibility to experimental autoimmune encephalomyelitis J:92437
increased susceptibility to experimental autoimmune encephalomyelitis J:92437
increased susceptibility to induced arthritis J:92437
increased susceptibility to type IV hypersensitivity reaction J:92437
rheumatoid arthritis J:92437
H2u/H2u
Rag1tm1Mom/Rag1tm1Mom
Tg(Tcra19,Tcrb19)#Stl/0
either: (involves: 129S7/SvEvBrd * C57BL/6 * PL/J) or (involves: 129S7/SvEvBrd * C57BL/6 * C57BL/10 * PL/J)
increased susceptibility to autoimmune disorder J:19795
limb paralysis J:19795
H2u/H2u
Tg(Tcra19,Tcrb19)#Stl/0
either: (involves: C57BL/6 * PL/J) or (involves: C57BL/6 * C57BL/10 * PL/J)
increased susceptibility to autoimmune disorder J:19795
increased susceptibility to experimental autoimmune encephalomyelitis J:19795
H2u/H2u
Tg(TCRA)B1Jg/0
B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRA)B1Jg/J
abnormal thymus cell ratio J:92992
decreased CD4-positive, alpha beta T cell number J:92992
decreased double-positive T cell number J:92992
decreased thymocyte number J:92992
increased double-negative T cell number J:92992
increased T cell derived lymphoma incidence J:92992
H2u/H2u
Tg(TCRA)B1Jg/0
Tg(TCRB)C14Jg/0
B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRA)B1Jg Tg(TCRB)C14Jg
abnormal double-negative T cell morphology J:92992
abnormal double-positive T cell morphology J:92992
abnormal thymus cell ratio J:92992
absent gamma-delta T cells J:92992
decreased double-positive T cell number J:92992
increased CD4-positive, alpha beta T cell number J:92992
increased double-negative T cell number J:92992
increased T cell derived lymphoma incidence J:92992
H2u/H2u
Tg(TCRA)B1Jg/?
Tg(TCRB)C14Jg/?
involves: C57BL/6 * C57BL/10SnSg * DBA/2 * PL/J
abnormal CD4-positive, alpha-beta T cell physiology J:92991
abnormal effector T cell morphology J:92991
decreased CD8-positive, alpha-beta T cell number J:92991
decreased double-positive T cell number J:92991
increased autoantibody level J:92991
increased CD4-positive, alpha beta T cell number J:92991
increased susceptibility to experimental autoimmune encephalomyelitis J:92991
paralysis J:92991
H2u/H2u
Tg(TCRB)C14Jg/0
B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRB)C14Jg/J
abnormal double-negative T cell morphology J:92992
abnormal double-positive T cell morphology J:92992
absent gamma-delta T cells J:92992
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
H2b/H2b
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
abnormal double-negative T cell morphology J:131357
abnormal double-positive T cell morphology J:81564
abnormal negative T cell selection J:81564
abnormal T cell differentiation J:81564
decreased double-positive T cell number J:131357
decreased thymocyte number J:131357
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
H2d/H2d
Ptcratm1Vbo/Ptcratm1Vbo
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
abnormal T cell differentiation J:131357
decreased thymocyte number J:131357

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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory