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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Gria4
glutamate receptor, ionotropic, AMPA4 (alpha 4)
MGI:95811
30 phenotypes from 6 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Gja10tm2.1(cre)Kwi/Gja10+
Gria4tm1Mony/Gria4tm1Mony
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal eye physiology J:207456
abnormal glutamate-mediated receptor currents J:207456
Gria4spkw1/Gria4+
involves: C3H/HeJ * C3HeB/FeJ
absence seizures J:135814
Gria4spkw1/Gria4spkw1
C3Fe.C3-Gria4spkw1
abnormal spike wave discharge J:228536
Gria4spkw1/Gria4spkw1
C3H/HeJ
absence seizures J:135814
Gria4spkw1/Gria4spkw1
involves: C3H/HeJ * C3HeB/FeJ
absence seizures J:135814
Gria4spkw1/Gria4spkw1
involves: C3H/HeJ * C57BL/6J
absence seizures J:98638
Gria4spkw1/Gria4tm1Dgen
involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J
absence seizures J:135814
Gria4tm1.1Mony/Gria4tm1.1Mony
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal action potential J:136763
abnormal AMPA-mediated synaptic currents J:136763
abnormal excitatory postsynaptic potential J:136763
abnormal inhibitory postsynaptic potential J:136763
abnormal nervous system electrophysiology J:136763
abnormal neuron physiology J:136763
abnormal object recognition memory J:136763
abnormal spatial working memory J:136763
decreased exploration in new environment J:136763
decreased vertical activity J:136763
impaired ability to fire action potentials J:136763
Gria4tm1Dgen/Gria4+
involves: 129P2/OlaHsd * C57BL/6J
absence seizures J:135814
Gria4tm1Dgen/Gria4tm1Dgen
involves: 129P2/OlaHsd * C57BL/6
abnormal seizure response to pharmacological agent J:101679
hyperactivity J:101679
increased thermal nociceptive threshold J:101679
Gria4tm1Dgen/Gria4tm1Dgen
involves: 129P2/OlaHsd * C57BL/6J
absence seizures J:135814
Gria4tm1Rlh/Gria4tm1Rlh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
normal nervous system phenotype J:99813
Gria4tm1Yfkk/Gria4tm1Yfkk
B6.129S-Gria4tm1Yfkk
abnormal social investigation J:178206
abnormal spatial reference memory J:178206
abnormal spatial working memory J:178206
normal behavior/neurological phenotype J:178206
decreased body weight J:178206
decreased grip strength J:178206
decreased prepulse inhibition J:178206
decreased startle reflex J:178206
decreased vertical activity J:178206
increased anxiety-related response J:178206
increased physiological sensitivity to xenobiotic J:178206
increased vertical activity J:178206
induced hyperactivity J:178206
normal nervous system phenotype J:178206

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory