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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Grb2
growth factor receptor bound protein 2
MGI:95805
12 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Grb2tm1.1Hua/Grb2tm1.1Hua
Tg(DO11.10)10Dlo/0
Tg(Lck-cre)1Jtak/0
involves: 129 * BALB/c * C3H * C57BL/6 		abnormal T cell differentiation J:161294
decreased CD4-positive, alpha-beta T cell number J:161294
Grb2tm1.1Hua/Grb2tm1.1Hua
Tg(Lck-cre)1Jtak/0
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129 * C57BL/6 * C57BL/6J * DBA/2J 		abnormal T cell differentiation J:161294
decreased CD4-positive, alpha-beta T cell number J:161294
decreased CD8-positive, alpha-beta T cell number J:161294
increased CD8-positive, alpha-beta T cell number J:161294
increased double-positive T cell number J:161294
Grb2tm1Paw/Grb2+
Ptentm1Mak/Pten+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		increased adrenal gland tumor incidence J:93530
increased endometrial carcinoma incidence J:93530
increased lymphoma incidence J:93530
increased tumor incidence J:93530
normal mortality/aging J:93530
Grb2tm1Paw/Grb2+
Ptentm2Mak/Ptentm2Mak
Tg(Lck-cre)548Jxm/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		increased T cell derived lymphoma incidence J:93530
Grb2tm1Paw/Grb2+
Tg(MMTV-PyVT)634Mul/?
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		increased mammary adenocarcinoma incidence J:51424
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory