67 phenotypes from 5 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gnai2tm1.1Rneu/Gnai2+ B6.129S1-Gnai2tm1.1Rneu	normal nervous system phenotype	J:197965
Gnai2tm1.1Rneu/Gnai2tm1.1Rneu involves: 129S1/Sv * C57BL/6	decreased body weight	J:121385
	decreased heart rate	J:121385
	increased heart rate	J:121385
	increased physiological sensitivity to xenobiotic	J:121385
	increased susceptibility to xenobiotic induced morbidity/mortality	J:121385
	premature death	J:121385
Gnai2tm1Lbi/Gnai2tm1Lbi 129-Gnai2tm1Lbi	abnormal cytokine secretion	J:91100
	normal immune system phenotype	J:91100
	increased interleukin-1 beta secretion	J:91100
	increased tumor necrosis factor secretion	J:91100
Gnai2tm1Lbi/Gnai2tm1Lbi B6.129S7-Gnai2tm1Lbi	abnormal cellular extravasation	J:120069
	abnormal eosinophil physiology	J:120069
	abnormal leukocyte adhesion	J:120069
	abnormal leukocyte cell number	J:121161
	abnormal T cell physiology	J:121161
	chronic diarrhea	J:125581
	decreased body weight	J:125581
	decreased eosinophil cell number	J:120069
	fatigue	J:125581
	increased eosinophil cell number	J:120069
	increased lymphocyte cell number	J:120069
	increased monocyte cell number	J:120069
	increased neutrophil cell number	J:120069
	premature death	J:125581
	rectal prolapse	J:125581
Gnai2tm1Lbi/Gnai2tm1Lbi either: 129 or (involves: 129S7/SvEvBrd * C57BL/6J)	abnormal cytokine secretion	J:24434
	increased granulocyte number	J:24434
	increased IgG level	J:24434
	increased IgM level	J:24434
	increased thymocyte number	J:24434
Gnai2tm1Lbi/Gnai2tm1Lbi involves: 129S7/SvEvBrd	abnormal colon morphology	J:24434, J:30507
	abnormal cytokine level	J:121471
	abnormal cytokine secretion	J:30507
	abnormal digestive system physiology	J:30507
	abnormal immune system morphology	J:30507
	abnormal immune system physiology	J:30507
	abnormal large intestine crypts of Lieberkuhn morphology	J:30507
	abnormal large intestine morphology	J:30507
	abnormal neutrophil physiology	J:121471
	abnormal response/metabolism to endogenous compounds	J:30507
	colitis	J:24434
	decreased body weight	J:30507
	decreased physiological sensitivity to xenobiotic	J:30507
	increased circulating interferon-gamma level	J:121471
	increased circulating interleukin-4 level	J:121471
	increased circulating interleukin-5 level	J:121471
	increased granulocyte number	J:30507
	increased IgA level	J:30507
	increased IgG level	J:30507
	increased immunoglobulin level	J:30507
	increased inflammatory response	J:30507
	increased interferon-gamma secretion	J:30507
	increased interleukin-2 secretion	J:30507
	increased intestinal adenocarcinoma incidence	J:24434
	increased physiological sensitivity to xenobiotic	J:30507
	increased single-positive T cell number	J:30507
	increased susceptibility to parasitic infection	J:121471
	increased T cell number	J:30507
	increased T cell proliferation	J:30507
	increased tumor necrosis factor secretion	J:30507
	intestinal ulcer	J:30507
	large intestinal inflammation	J:30507
	lethality during fetal growth through weaning, complete penetrance	J:24434
	megacolon	J:30507
	peritoneal inflammation	J:30507
	postnatal growth retardation	J:30507
	premature death	J:30507
	weight loss	J:30507
Gnai2tm1Lbi/Gnai2tm1Lbi involves: 129S7/SvEvBrd * C57BL/6	abnormal cytokine secretion	J:91100
	colitis	J:91100
	increased interleukin-1 beta secretion	J:91100
	increased tumor necrosis factor secretion	J:91100
Gnai2tm1Lbi/Gnai2tm1Lbi involves: 129S7/SvEvBrd * C57BL/6J	abnormal colon morphology	J:24434
	colitis	J:24434
	decreased body weight	J:24434
	increased intestinal adenocarcinoma incidence	J:24434
	postnatal growth retardation	J:24434
	postnatal lethality, incomplete penetrance	J:24434
	premature death	J:24434
Gnai2tm1Rmm/Gnai2tm1Rmm involves: 129S4/SvJae * C57BL/6	normal cardiovascular system phenotype	J:68045
Gnai2tm2.1Lbi/Gnai2tm2.1Lbi Tg(Cd4-cre)1Cwi/0 involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * DBA	decreased T-helper 17 cell number	J:194587
	increased incidence of tumors by chemical induction	J:194587
	increased susceptibility to induced colitis	J:194587
Gnai2tm2.1Rneu/Gnai2tm2.1Rneu B6.129(Cg)-Gnai2tm2.1Rneu	no abnormal phenotype detected	J:217517
Gnai2tm2.1Rneu/Gnai2tm2.1Rneu Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+ B6.Cg-Gt(ROSA)26Sortm1(cre/ert2)Tyj Gnai2tm2.1Rneu	abnormal response to cardiac infarction	J:217517
	decreased myocardial infarct size	J:217517