Gna13 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gna13
guanine nucleotide binding protein, alpha 13
MGI:95768

27 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cd19^tm1(cre)Cgn/Cd19⁺ Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2.1Soff/Gna13^tm2.1Soff involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6N	abnormal B cell physiology	J:117663
	decreased marginal zone B cell number	J:117663
Gna12^tm1.1Cgh/Gna12^tm1.1Cgh Gna13^tm2Cgh/Gna13^tm2Cgh Tg(Mx1-cre)1Cgn/0 involves: 129S4/SvJae * C57BL/6 * CBA	abnormal germinal center B cell morphology	J:174313
	decreased B cell apoptosis	J:174313
	increased germinal center B cell number	J:174313
Gna12^tm1Citb/Gna12⁺ Gna13^tm1Soff/Gna13⁺ involves: 129S1/Sv * C57BL/6	no abnormal phenotype detected	J:77728
Gna12^tm1Citb/Gna12⁺ Gna13^tm1Soff/Gna13^tm1Soff involves: 129S1/Sv * C57BL/6	embryonic growth arrest	J:77728
	embryonic lethality, complete penetrance	J:77728
Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm1Soff/Gna13⁺ involves: 129S1/Sv * C57BL/6	embryonic lethality, complete penetrance	J:77728
Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm1Soff/Gna13^tm1Soff involves: 129S1/Sv * C57BL/6	embryonic growth arrest	J:77728
	embryonic lethality, complete penetrance	J:77728
Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2.1Soff/Gna13^tm2.1Soff Tg(Lck-cre)548Jxm/0 involves: 129S1/Sv * C57BL/6 * CBA	abnormal CD4-positive, alpha-beta T cell physiology	J:149560
	increased CD4-positive, alpha-beta T cell number	J:149560
	increased CD8-positive, alpha-beta T cell number	J:149560
	increased interleukin-2 secretion	J:149560
	increased susceptibility to autoimmune diabetes	J:149560
	increased susceptibility to type IV hypersensitivity reaction	J:149560
	increased T cell proliferation	J:149560
	lymph node hyperplasia	J:149560
	thymus hyperplasia	J:149560
Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2.1Soff/Gna13^tm2.1Soff Tg(Mx1-cre)1Cgn/0 involves: 129S1/Sv * C57BL/6 * CBA * FVB/N	abnormal blood coagulation	J:99597
	abnormal platelet physiology	J:99597
	decreased platelet aggregation	J:99597
	increased bleeding time	J:99597
Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2.1Soff/Gna13^tm2.1Soff X/Tg(Myh11-icre/ERT2)1Soff involves: 129S1/Sv * FVB/N	decreased systemic arterial blood pressure	J:141641
	decreased vasoconstriction	J:141641
Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2.1Soff/Gna13^tm2.1Soff Tg(Tek-icre/ERT2)1Soff/? involves: 129P2/OlaHsd * 129S1/Sv * FVB/N	normal cardiovascular system phenotype	J:146132
Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2Cgh/Gna13^tm2Cgh Grhl3^tm1(cre)Cgh/Grhl3⁺ involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL	abnormal embryo development	J:157446
	abnormal embryo turning	J:157446
	embryonic lethality during organogenesis, complete penetrance	J:157446

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