54 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Artm2Ska/Y Gli1tm3(cre/ERT2)Alj/Gli1+ involves: 129S6/SvEvTac * C57BL/6 * CBA	abnormal external male genitalia morphology	J:148515
	abnormal foreskin morphology	J:148515
	abnormal reproductive system development	J:148515
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt Gli1tm3(cre/ERT2)Alj/Gli1+ involves: 129S6/SvEvTac * 129X1/SvJ	abnormal external female genitalia morphology	J:148515
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm Gli1tm3(cre/ERT2)Alj/Gli1+ involves: 129P2/OlaHsd * 129S6/SvEvTac	abnormal external male genitalia morphology	J:148515
	abnormal foreskin morphology	J:148515
En1tm2(cre)Gld/En1+ Gli1tm2Alj/Gli1tm2Alj Gli2tm1Alj/Gli2tm6Alj involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster	abnormal cerebellar foliation	J:108507
	abnormal cerebellum development	J:108507
	abnormal cerebellum morphology	J:108507
Gata6tm2.1Sad/Gata6tm2.1Sad Gli1tm1Alj/Gli1tm1Alj Tg(Prrx1-cre)1Cjt/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J	polydactyly	J:205405
Gli1tm1Alj/Gli1+ Gli2tm1Alj/Gli2tm1Alj involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal lung morphology	J:60986
	small lung	J:60986
Gli1tm1Alj/Gli1tm1Alj Gli2tm1Alj/Gli2+ involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal digestive system morphology	J:60986
	abnormal external male genitalia morphology	J:60986
	abnormal floor plate morphology	J:60986
	abnormal gait	J:60986
	abnormal left lung morphology	J:60986
	abnormal lung morphology	J:60986
	abnormal motor neuron morphology	J:60986
	abnormal notochord morphology	J:60986
	abnormal right lung accessory lobe morphology	J:60986
	abnormal right lung cranial lobe morphology	J:60986
	cryptorchism	J:60986
	decreased body size	J:60986
	impaired righting response	J:60986
	neonatal lethality, incomplete penetrance	J:60986
	small lung	J:60986
Gli1tm1Alj/Gli1tm1Alj Gli2tm1Alj/Gli2tm1Alj involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal digit morphology	J:60986
	abnormal lung morphology	J:60986
	abnormal motor neuron morphology	J:60986
	abnormal telencephalon morphology	J:60986
	absent pituitary gland	J:60986
	lethality throughout fetal growth and development, incomplete penetrance	J:60986
	perinatal lethality, complete penetrance	J:60986
	small lung	J:60986
Gli1tm1Alj/Gli1tm1Alj Gli3Xt-J/Gli3+ involves: 129S1/Sv * 129X1/SvJ * CD-1	polydactyly	J:60986
Gli1tm1Alj/Gli1tm1Alj Glis1tm1Mnks/Glis1tm1Mnks mixed	no abnormal phenotype detected	J:80052
Gli1tm1Alj/Gli1tm1Alj Ptch1tm1Mps/Ptch1tm1Mps involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster	embryonic lethality during organogenesis, complete penetrance	J:79392
Gli1tm1Alj/Gli1tm1Alj Tg(Shh)#Dje/0 involves: 129S1/Sv * 129X1/SvJ * Swiss Webster	abnormal cell proliferation	J:94461
	abnormal cerebellar granule layer morphology	J:94461
	abnormal cerebellar lobule formation	J:94461
	abnormal cerebellum external granule cell layer morphology	J:94461
	abnormal cerebellum morphology	J:94461
Gli1tm2Alj/Gli1+ Gli2tm1Alj/Gli2tm1Alj involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster	small lung	J:79392
Gli1tm2Alj/Gli1+ Gli2tm1Alj/Gli2tm1Alj Gli3Xt/Gli3Xt involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster	abnormal motor neuron morphology	J:87948
	abnormal neuron differentiation	J:87948
	abnormal neuronal precursor cell number	J:87948
	abnormal neuronal precursor proliferation	J:87948
	abnormal spinal cord morphology	J:87948
	abnormal ventral interneuron 3 morphology	J:87948
	abnormal ventral interneuron morphology	J:87948
	absent floor plate	J:87948
	decreased motor neuron number	J:87948
Gli1tm2Alj/Gli1tm2Alj Gli2tm1Alj/Gli2+ involves: 129 * Black Swiss * Swiss Webster	abnormal floor plate morphology	J:79392
	persistence of notochord tissue	J:79392
	small lung	J:79392
Gli1tm2Alj/Gli1tm2Alj Gli2tm1Alj/Gli2tm1Alj involves: 129/Sv * Black Swiss * Swiss Webster	impaired lung lobe morphogenesis	J:79392
	polydactyly	J:79392
	small lung	J:79392
Gli1tm2Alj/Gli1tm2Alj Gli2tm3.1(Gli1)Alj/Gli2tm3.1(Gli1)Alj involves: 129/Sv * Black Swiss * Swiss Webster	normal nervous system phenotype	J:79392
Gli1tm2Alj/Gli1tm2Alj Gli2tm5.1(GLI3)Alj/Gli2tm5.1(GLI3)Alj involves: 129S6/SvEvTac * Swiss Webster	abnormal ventral interneuron 3 morphology	J:87948
	absent floor plate	J:87948
Gli1tm3(cre/ERT2)Alj/Gli1+ Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+ involves: 129S6/SvEvTac * 129X1/SvJ	normal respiratory system phenotype	J:264185
Gli1tm3(cre/ERT2)Alj/Gli1+ Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc involves: 129S6/SvEvTac * 129X1/SvJ	increased medulloblastoma incidence	J:139574
	premature death	J:139574
Gli1tm3(cre/ERT2)Alj/Gli1+ Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ Tnntm1b(KOMP)Wtsi/Tnntm1b(KOMP)Wtsi involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N	abnormal tooth development	J:302206
Gt(ROSA)26Sortm2(HOXC9)Odk/Gt(ROSA)26Sortm2(HOXC9)Odk Gli1tm3(cre/ERT2)Alj/Gli1+ involves: 129S6/SvEvTac	normal craniofacial phenotype	J:201472
Slfn4tm1c(EUCOMM)Wtsi/Slfn4tm1c(EUCOMM)Wtsi Gli1tm3(cre/ERT2)Alj/Gli1+ involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * Swiss Webster	abnormal CD8-positive, alpha-beta cytotoxic T cell morphology	J:337060
	abnormal interleukin level	J:337060
	abnormal stomach mucosa morphology	J:337060
	abnormal tumor necrosis factor level	J:337060
	decreased susceptibility to bacterial infection	J:337060