Gabrd Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gabrd
gamma-aminobutyric acid (GABA) A receptor, subunit delta
MGI:95622

22 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gabrd^tm1.1Jmag/Gabrd⁺ Gad2^tm2(cre)Zjh/Gad2⁺ involves: 129S4/SvJae * C57BL/6 * SJL	abnormal CNS synaptic transmission	J:203336
	abnormal GABAergic neuron physiology	J:203336
	abnormal inhibitory postsynaptic currents	J:203336
	decreased susceptibility to pharmacologically induced seizures	J:203336
	impaired ability to fire action potentials	J:203336
	increased excitatory postsynaptic current amplitude	J:203336
Gabrd^tm1Geh/Gabrd^tm1Geh involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal depression-related behavior	J:145475
	abnormal maternal nurturing	J:145475
	abnormal nervous system electrophysiology	J:145475
	abnormal nest building behavior	J:145475
	abnormal pup retrieval	J:145475
	behavioral despair	J:145475
	normal hearing/vestibular/ear phenotype	J:112951
	increased anxiety-related response	J:145475
	pup cannibalization	J:145475
Gabrd^tm1Geh/Gabrd^tm1Geh involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal contextual conditioning behavior	J:110073
	abnormal cued conditioning behavior	J:110073
	abnormal inhibitory postsynaptic currents	J:64288
	absence seizures	J:64288
	decreased anxiety-related response	J:64288
	decreased litter size	J:64288
	impaired behavioral response to anesthetic	J:64288
	postnatal lethality	J:64288

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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