Gabra5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gabra5
gamma-aminobutyric acid type A receptor subunit alpha 5
MGI:95617

29 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gabra5^{em1(IMPC)Ccpcz}/Gabra5^{em1(IMPC)Ccpcz} C57BL/6N-Gabra5^{em1(IMPC)Ccpcz}/Ccpcz	abnormal heart morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal testis morphology	J:211773
	abnormal thymus morphology	J:211773
	enlarged heart	J:211773
	enlarged thymus	J:211773
	small spleen	J:211773
	small testis	J:211773
Gabra5^tm1.1Uru/Gabra5^tm1.1Uru 129X1/SvJ-Gabra5^tm1.1Uru	abnormal behavioral response to xenobiotic	J:77343
	abnormal hippocampus CA1 region morphology	J:77343
	decreased fluid intake	J:128874
	decreased prepulse inhibition	J:127869
	enhanced cued conditioning behavior	J:77343
	increased locomotor activity	J:127869
Gabra5^tm1Twr/Gabra5^tm1Twr involves: 129S7/SvEvBrd	abnormal contextual conditioning behavior	J:107253
	abnormal GABA-mediated receptor currents	J:107253
	abnormal long-term potentiation	J:107253
	abnormal spatial learning	J:107253
Gabra5^tm1Twr/Gabra5^tm1Twr involves: 129S7/SvEvBrd * C57BL/6	abnormal auditory brainstem response waveform shape	J:112951
	abnormal cochlea morphology	J:112951
	abnormal cochlear OHC efferent innervation pattern	J:112951
	abnormal distortion product otoacoustic emission	J:112951
	abnormal inhibitory postsynaptic currents	J:108206
	abnormal spatial learning	J:108206
	cochlear ganglion degeneration	J:112951
	cochlear inner hair cell degeneration	J:112951
	cochlear outer hair cell degeneration	J:112951
	increased or absent threshold for auditory brainstem response	J:112951
	sensorineural hearing loss	J:112951
	type IV spiral ligament fibrocyte degeneration	J:112951

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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