98 phenotypes from 9 alleles in 13 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Fyntm1a(EUCOMM)Wtsi/Fyntm1a(EUCOMM)Wtsi C57BL/6N-Fyntm1a(EUCOMM)Wtsi/Wtsi	preweaning lethality, complete penetrance	J:211773
Fyntm1Fam/Fyntm1Fam involves: C57BL/6	abnormal myelination	J:109485
Fyntm1Rmp/Fyntm1Rmp B6.129S2-Fyntm1Rmp	abnormal eosinophil physiology	J:114287
	abnormal interleukin-4 secretion	J:114287
	decreased IgE level	J:114287
	decreased interleukin-2 secretion	J:114287
	increased interleukin-5 secretion	J:114287
	increased susceptibility to type I hypersensitivity reaction	J:114287
Fyntm1Rmp/Fyntm1Rmp involves: 129S2/SvPas	decreased gamma-delta T cell number	J:37062
	decreased T cell number	J:37062
Fyntm1Rmp/Fyntm1Rmp involves: 129S2/SvPas * C57BL/6	abnormal T cell activation	J:70886
	abnormal thymocyte activation	J:70886
	decreased T cell proliferation	J:70886
Fyntm1Sor/Fyn+ Tg(Camk2a-Fyn-531)1Nko/0 involves: 129S7/SvEvBrd * C57BL/6 * CBA	abnormal motor capabilities/coordination/movement	J:59490
	premature death	J:59490
	tonic seizures	J:59490
Fyntm1Sor/Fyntm1Sor B6.129S7-Fyntm1Sor	abnormal CD4-positive, alpha-beta T cell physiology	J:93886
	abnormal NK cell physiology	J:187430
	abnormal T cell proliferation	J:93886
	decreased IgE level	J:93886
	decreased interferon-gamma secretion	J:187430
Fyntm1Sor/Fyntm1Sor either: 129S7/SvEvBrd-Fyntm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)	abnormal dentate gyrus morphology	J:3417
	abnormal hippocampus pyramidal cell layer	J:3417
	abnormal hippocampus pyramidal cell morphology	J:3417
	abnormal immune cell physiology	J:2242
	abnormal spatial learning	J:3417
	abnormal T cell clonal deletion	J:2242
	abnormal T cell physiology	J:2242
	abnormal thymocyte activation	J:2242
	decreased interleukin-2 secretion	J:2242
	decreased T cell proliferation	J:2242
	increased hippocampus pyramidal cell number	J:3417
	increased IgG2a level	J:2242
	increased IgM level	J:2242
	reduced long-term potentiation	J:3417
Fyntm1Sor/Fyntm1Sor involves: 129S7/SvEvBrd	abnormal chemokine level	J:80658
	abnormal macrophage physiology	J:80658
Fyntm1Sor/Fyntm1Sor involves: 129S7/SvEvBrd * C57BL/6J	abnormal dentate gyrus morphology	J:80637
	abnormal hippocampus morphology	J:80637
	abnormal hippocampus pyramidal cell layer	J:80637
	abnormal hippocampus pyramidal cell morphology	J:80637
	abnormal myelination	J:109485
	abnormal optic nerve morphology	J:109485
	abnormal sperm capacitation	J:185783
	abnormal sperm connecting piece morphology	J:185783
	abnormal sperm head morphology	J:185783
	abnormal sperm motility	J:185783
	abnormal spermatogenesis	J:185783
	abnormal spermiogenesis	J:185783
	decreased corpus callosum size	J:109485
	decreased epididymis weight	J:185783
	decreased fertilization frequency	J:185783
	ectopic hippocampus pyramidal cells	J:80637
	impaired acrosome reaction	J:185783
	impaired sperm penetration of zona pellucida	J:185783
	oligozoospermia	J:185783
	reduced long-term potentiation	J:80637
	normal reproductive system phenotype	J:185783
	teratozoospermia	J:185783
Fyntm1Sor/Fyntm1Sor Tg(Camk2a-Fyn)1Kndl/0 involves: 129S7/SvEvBrd * C57BL/6 * CBA	abnormal dentate gyrus morphology	J:80637
	abnormal hippocampus morphology	J:80637
	abnormal hippocampus pyramidal cell layer	J:80637
	abnormal hippocampus pyramidal cell morphology	J:80637
	ectopic hippocampus pyramidal cells	J:80637
Fyntm1Yik/Fyn+ involves: C57BL/6 * CBA	prolonged circadian behavior period	J:63170
Fyntm1Yik/Fyntm1Yik involves: C57BL/6 * CBA	abnormal cytokine secretion	J:99347
	abnormal ectoplasmic specialization morphology	J:74017
	abnormal excitatory postsynaptic potential	J:43707
	abnormal hippocampus layer morphology	J:16461
	abnormal hypothalamus morphology	J:63170
	abnormal interleukin secretion	J:99347
	abnormal locomotor circadian rhythm	J:63170
	abnormal maternal nurturing	J:101992
	abnormal myelination	J:16847
	abnormal olfaction	J:101992
	abnormal olfactory bulb morphology	J:16461
	abnormal pup retrieval	J:101992
	abnormal seminiferous tubule morphology	J:74017
	abnormal somatosensory cortex morphology	J:103576
	abnormal startle reflex	J:74705
	abnormal stratification in cerebral cortex	J:103576
	abnormal suckling behavior	J:16461
	audiogenic seizures	J:23384
	decreased testis weight	J:74017
	enhanced behavioral response to alcohol	J:43707
	enhanced passive avoidance behavior	J:21225
	increased dopamine level	J:74705
	increased fear-related response	J:21225, J:74705
	increased serotonin level	J:74705
	increased susceptibility to experimental autoimmune uveoretinitis	J:99347
	increased susceptibility to xenobiotic induced morbidity/mortality	J:101992
	increased tumor necrosis factor secretion	J:99347
	oligozoospermia	J:74017
	prolonged circadian behavior period	J:63170
	small seminiferous tubules	J:74017
Tg(Camk2a-Fyn-531)1Nko/0 B6.Cg-Tg(Camk2a-Fyn-531)1Nko	abnormal locomotor behavior	J:79980
	alcohol aversion	J:79980
	decreased anxiety-related response	J:79980
	decreased behavioral withdrawal response	J:79980
	impaired behavioral response to alcohol	J:79980
Tg(Camk2a-Fyn-531)1Nko/0 involves: 129S7/SvEvBrd * C57BL/6 * CBA	abnormal kindling response	J:59490
	abnormal motor capabilities/coordination/movement	J:59490
	abnormal seizure response to electrical stimulation	J:59490
	increased susceptibility to pharmacologically induced seizures	J:59490
	premature death	J:59490
	tonic seizures	J:59490
Tg(Krt14-Fyn)AJsey/0 involves: C57BL/6 * CBA	abnormal filiform papillae morphology	J:118155
	abnormal keratinocyte morphology	J:118155
	decreased body size	J:118155
	decreased eating frequency	J:118155
	epidermal hyperplasia	J:118155
	postnatal lethality	J:118155
	psoriasis	J:118155
	thick epidermis	J:118155
Tg(KRT14-Fyn*)aJsey/0 involves: C57BL/6 * CBA	abnormal keratinocyte morphology	J:155536
	epidermal hyperplasia	J:155536
	increased skin squamous cell carcinoma incidence	J:155536
	thick epidermis	J:155536
Tg(KRT14-Fyn*)aJsey/0 involves: C57BL/6 * CBA * FVB/N	abnormal keratinocyte differentiation	J:155536
	abnormal keratinocyte morphology	J:155536
	epidermal hyperplasia	J:155536
	hyperkeratosis	J:155536
	increased skin squamous cell carcinoma incidence	J:155536
	parakeratosis	J:155536
	thick epidermis	J:155536