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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fcgr2b
Fc receptor, IgG, low affinity IIb
MGI:95499
50 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Fcer1atm1Knt/Fcer1atm1Knt
Fcer2atm1Max/Fcer2atm1Max
Fcgr1tm1Jsv/Fcgr1tm1Jsv
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Fcgr3tm1Jsv/Fcgr3tm1Jsv
B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max 		abnormal macrophage physiology J:144620
abnormal mast cell physiology J:144620
increased susceptibility to type I hypersensitivity reaction J:144620
Fcgr1tm1Jsv/Fcgr1tm1Jsv
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Fcgr3tm1Jsv/Fcgr3tm1Jsv
involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 		impaired macrophage phagocytosis J:83995
Fcgr2btm1.2Jsv/Fcgr2b+
X/Yaa
involves: C57BL/6 * FVB/N * SB/Le 		abnormal kidney morphology J:179175
enlarged spleen J:179175
increased anti-chromatin antibody level J:179175
increased anti-double stranded DNA antibody level J:179175
increased monocyte cell number J:179175
increased susceptibility to systemic lupus erythematosus J:179175
premature death J:179175
Fcgr2btm1.2Jsv/Fcgr2btm1.2Jsv
Sle16C57BL/6/Sle16C57BL/6
involves: C57BL/6 * FVB/N 		abnormal adaptive immunity J:179175
abnormal glomerular capillary thrombosis J:179175
abnormal renal glomerulus morphology J:179175
albuminuria J:179175
normal immune system phenotype J:179175
increased immunoglobulin level J:179175
increased susceptibility to induced arthritis J:179175
kidney inflammation J:179175
Fcgr2btm1Ttk/Fcgr2b+
X/Yaa
involves: 129S4/SvJae * C57BL/6 * SB/Le 		increased monocyte cell number J:129409
Fcgr2btm1Ttk/Fcgr2btm1.2Jsv
Sle21129P2/Ola/Sle21C57BL/6
involves: 129P2/Ola * 129S4/SvJae * C57BL/6 * FVB/N 		abnormal kidney morphology J:179175
albuminuria J:179175
enlarged spleen J:179175
increased anti-chromatin antibody level J:179175
increased anti-double stranded DNA antibody level J:179175
increased anti-histone antibody level J:179175
increased anti-single stranded DNA antibody level J:179175
increased spleen weight J:179175
increased susceptibility to systemic lupus erythematosus J:179175
premature death J:179175
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Il17atm1Yiw/Il17a+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		decreased survivor rate J:191090
glomerulonephritis J:191090
increased plasma cell number J:191090
increased spleen germinal center number J:191090
kidney inflammation J:191090
premature death J:191090
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Il17atm1Yiw/Il17atm1Yiw
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		decreased survivor rate J:191090
decreased susceptibility to systemic lupus erythematosus J:191090
increased anti-double stranded DNA antibody level J:191090
increased anti-nuclear antigen antibody level J:191090
increased double-negative T cell number J:191090
increased plasma cell number J:191090
increased spleen germinal center number J:191090
premature death J:191090
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Pdcd1tm1Hon/Pdcd1tm1Hon
involves: 129S2/SvPas * 129S4/SvJae * BALB/c 		abnormal cytokine level J:207275
abnormal urinary bladder urothelium morphology J:207275
abnormal urine cytokine level J:207275
decreased body weight J:207275
increased autoantibody level J:207275
oliguria J:207275
urinary bladder inflammation J:207275
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Sle21129P2/Ola/Sle21129P2/Ola
B6.129S4-Fcgr2btm1Ttk 		abnormal adaptive immunity J:179175
abnormal glomerular capillary thrombosis J:179175
abnormal renal glomerulus morphology J:179175
albuminuria J:179175
enlarged spleen J:179175
increased anti-chromatin antibody level J:179175
increased anti-double stranded DNA antibody level J:179175
increased anti-histone antibody level J:179175
increased anti-single stranded DNA antibody level J:179175
increased autoantibody level J:179175
increased IgG2a level J:179175
increased immunoglobulin level J:179175
increased spleen weight J:179175
increased susceptibility to induced arthritis J:179175
increased susceptibility to systemic lupus erythematosus J:179175
kidney inflammation J:179175
premature death J:179175
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Tg(Ins2-TFRC/OVA)296Wehi/0
involves: 129S4/SvJae * C57BL/6 		increased susceptibility to autoimmune diabetes J:122114
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Tlr7tm1Flv/Y
X/Yaa
B6.Cg-Fcgr2btm1Ttk Tlr7tm1Flv Yaa 		abnormal kidney morphology J:127600
abnormal splenocyte physiology J:127600
autoimmune response J:127600
enlarged spleen J:127600
increased anti-nuclear antigen antibody level J:127600
increased susceptibility to systemic lupus erythematosus J:127600
premature death J:127600
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Traf3ip2tm1Sbn/Traf3ip2+
involves: 129 * 129S4/SvJae * C57BL/6 		abnormal neutrophil morphology J:191090
abnormal T cell morphology J:191090
decreased survivor rate J:191090
increased anti-double stranded DNA antibody level J:191090
increased anti-nuclear antigen antibody level J:191090
increased autoantibody level J:191090
increased double-negative T cell number J:191090
increased IgG level J:191090
increased memory T cell number J:191090
increased monocyte cell number J:191090
increased myeloid dendritic cell number J:191090
increased neutrophil cell number J:191090
increased plasma cell number J:191090
increased plasmacytoid dendritic cell number J:191090
increased single-positive T cell number J:191090
increased spleen germinal center number J:191090
increased susceptibility to systemic lupus erythematosus J:191090
kidney inflammation J:191090
premature death J:191090
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Traf3ip2tm1Sbn/Traf3ip2tm1Sbn
involves: 129 * 129S4/SvJae * C57BL/6 		abnormal T cell morphology J:191090
decreased survivor rate J:191090
decreased susceptibility to systemic lupus erythematosus J:191090
increased anti-double stranded DNA antibody level J:191090
increased anti-nuclear antigen antibody level J:191090
increased autoantibody level J:191090
increased double-negative T cell number J:191090
increased IgG level J:191090
premature death J:191090
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Traf3ip2tm2Sbn/Traf3ip2+
involves: 129S4/SvJae * BALB/c * C57BL/6 		enlarged spleen J:191090
increased germinal center B cell number J:191090
increased plasma cell number J:191090
increased spleen weight J:191090
spleen hyperplasia J:191090
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Traf3ip2tm2Sbn/Traf3ip2tm2Sbn
Cd79atm1(cre)Reth/Cd79a+
involves: 129S4/SvJae * BALB/c * C57BL/6 		glomerulonephritis J:191090
increased germinal center B cell number J:191090
increased plasma cell number J:191090
Fcgr2btm1Ttk/Fcgr2btm1Ttk
X/Yaa
B6.Cg-Fcgr2btm1Ttk Yaa 		abnormal kidney morphology J:127600
autoimmune response J:127600
enlarged spleen J:127600
increased anti-nuclear antigen antibody level J:127600
increased susceptibility to systemic lupus erythematosus J:127600
premature death J:127600
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory