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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Fbn1
fibrillin 1
MGI:95489
32 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Fbn1tm1.2Lysa/Fbn1+
Fbn2tm1Rmz/Fbn2tm1Rmz
involves: 129/Sv * C57BL/6
neonatal lethality, incomplete penetrance J:165897
prenatal lethality, incomplete penetrance J:165897
Fbn1tm1Hcd/Fbn1+
Tgfb2tm1Doe/Tgfb2+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
abnormal aorta wall morphology J:188799
aortic aneurysm J:188799
dilated aorta bulb J:188799
normal growth/size/body region phenotype J:188799
Fbn1tm2.1Hcd/Fbn1+
Itgb3tm1Hyn/Itgb3+
involves: 129S * 129X1/SvJ * C57BL/6J * FVB/N
abnormal cutaneous collagen fibril morphology J:206074
epidermal hyperplasia J:206074
normal integument phenotype J:206074
thick dermal layer J:206074
Fbn1tm3.1Hcd/Fbn1+
Itgb3tm1Hyn/Itgb3+
involves: 129S * 129X1/SvJ * C57BL/6J * FVB/N
abnormal cutaneous collagen fibril morphology J:206074
epidermal hyperplasia J:206074
normal integument phenotype J:206074
thick dermal layer J:206074
Fbn1tm3Rmz/Fbn1+
Fbn2tm1Rmz/Fbn2tm1Rmz
involves: 129
abnormal aorta tunica media morphology J:110586
lethality throughout fetal growth and development, incomplete penetrance J:110586
Fbn1tm3Rmz/Fbn1tm3Rmz
Fbn2tm1Rmz/Fbn2tm1Rmz
involves: 129
abnormal aorta tunica media morphology J:110586
lethality throughout fetal growth and development, complete penetrance J:110586
Fbn1Tsk/Fbn1+
KitW/Kit+
involves: C57BL/6 * C57BL/10 * DBA/2 * WB/ReJ
diluted coat color J:24076
skin fibrosis J:24076
tight skin J:24076
variable body spotting J:24076
Fbn1Tsk/Fbn1+
KitW/KitW-v
involves: C57BL/6 * C57BL/10 * DBA/2 * WB/ReJ
abnormal hypodermis morphology J:24076
absent coat pigmentation J:24076
absent mast cells J:24076
anemia J:24076
overexpanded pulmonary alveoli J:24076
skin fibrosis J:24076
tight skin J:24076
Fbn1Tsk/Fbn1+
Il4tm1Nnt/Il4tm1Nnt
involves: C57BL/6 * C57BL/10 * DBA/2
decreased interleukin-4 secretion J:57957
emphysema J:57957
normal integument phenotype J:57957
Fbn1Tsk/Fbn1+
Tgfb1tm1N/Tgfb1+
involves: 129S/SvEv * C57BL/6J * C57BL/10 * DBA/2
abnormal cutaneous collagen fibril morphology J:68448
normal immune system phenotype J:68448
overexpanded pulmonary alveoli J:68448
Fbn1Tsk/Fbn1+
Tgfb1tm1N/Tgfb1tm1N
involves: 129S/SvEv * C57BL/6J * C57BL/10 * DBA/2
prenatal lethality J:68448
Fbn1Tsk/Fbn1+
Il4ratm1Sz/Il4ra+
involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2
increased autoantibody level J:68448
overexpanded pulmonary alveoli J:68448
thick skin J:68448
Fbn1Tsk/Fbn1+
Il4ratm1Sz/Il4ratm1Sz
involves: BALB/cJ * C57BL/6J * C57BL/10 * DBA/2
abnormal cutaneous collagen fibril morphology J:68448
normal immune system phenotype J:68448
normal integument phenotype J:68448
overexpanded pulmonary alveoli J:68448
Fbn1Tsk/Fbn1+
Stat6tm1Gru/Stat6tm1Gru
involves: 129S2/SvPas * C57BL/10 * DBA/2
decreased interleukin-4 secretion J:57957
emphysema J:57957
normal integument phenotype J:57957
Fbn1Tsk/Fbn1+
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: C57BL/10 * DBA/2
emphysema J:57957
normal integument phenotype J:57957
Fbn1Tsk/Fbn1+
Tg(Tcra2C,Tcrb2C)1Dlo/?
involves: C57BL/10 * DBA/2
emphysema J:57957
normal integument phenotype J:57957
Fbn1Tsk Bloc1s6+/Fbn1+ Bloc1s6pa
B6.Cg-Fbn1Tsk +/+ Bloc1s6pa/J
abnormal vascular endothelial cell physiology J:81020
abnormal vasodilation J:81020
normal cellular phenotype J:55591
normal hematopoietic system phenotype J:29151

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory