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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fas
Fas cell surface death receptor
MGI:95484
218 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Agtpbp1atms/Agtpbp1atms
Faslpr/?
MRL/Mp-Agtpbp1atms Faslpr 		abnormal cerebellar foliation J:103945
abnormal cerebellum morphology J:103945
abnormal stellate ganglion morphology J:103945
arrest of spermatogenesis J:103945
ataxia J:103945
decreased brain weight J:103945
decreased Purkinje cell number J:103945
female infertility J:103945
impaired coordination J:103945
male infertility J:103945
oligozoospermia J:103945
small cerebellum J:103945
thin cerebellar granule layer J:103945
thin cerebellar molecular layer J:103945
Agtpbp1atms/Agtpbp1atms
Faslpr/Faslpr
MRL/Mp-Agtpbp1atms Faslpr 		ataxia J:103944
enlarged lymph nodes J:103944
enlarged spleen J:103944
normal integument phenotype J:103944
Apoetm1Unc/Apoetm1Unc
Faslpr/Faslpr
B6.Cg-Apoetm1Unc Faslpr 		abnormal aorta morphology J:121671
abnormal heart morphology J:121671
abnormal trabecular bone morphology J:121671
abnormal vascular endothelial cell morphology J:121671
atherosclerotic lesions J:121671
decreased autoantibody level J:121671
decreased bone mineral density J:121671
decreased bone mineral density of femur J:121671
decreased bone mineral density of vertebrae J:121671
decreased bone trabecula number J:121671
decreased CD4-positive, alpha-beta T cell number J:121671
decreased CD8-positive, alpha-beta T cell number J:121671
decreased circulating cholesterol level J:121671
decreased trabecular bone connectivity density J:121671
decreased trabecular bone thickness J:121671
decreased trabecular bone volume J:121671
enlarged lymph nodes J:121671
enlarged spleen J:121671
enlarged thymus J:121671
glomerulonephritis J:121671
normal hematopoietic system phenotype J:121671
increased anti-double stranded DNA antibody level J:121671
increased autoantibody level J:121671
increased IgG level J:121671
increased kidney apoptosis J:121671
increased renal glomerulus lobularity J:121671
increased renal tubule apoptosis J:121671
increased urine protein level J:121671
renal glomerular immunoglobulin deposits J:121671
renal glomerulus hypertrophy J:121671
Apoetm1Unc/Apoetm1Unc
Faslpr/Faslpr
MRL.Cg-Apoetm1Unc Faslpr 		increased anti-double stranded DNA antibody level J:133606
increased anti-nuclear antigen antibody level J:133606
increased autoantibody level J:133606
increased circulating cholesterol level J:133606
increased immunoglobulin level J:133606
increased susceptibility to atherosclerosis J:133606
increased susceptibility to systemic lupus erythematosus J:133606
Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Faslpr/Faslpr
B6.Cg-Bcl2l11tm1.1Ast Faslpr 		abnormal effector T cell morphology J:132217
abnormal glomerular capillary morphology J:132217
abnormal kidney morphology J:132217
abnormal lymph node cell ratio J:132217
abnormal renal glomerulus basement membrane morphology J:132217
abnormal renal glomerulus morphology J:132217
abnormal splenic cell ratio J:132217
abnormal T cell number J:132217
abnormal T cell subpopulation ratio J:132217
decreased B cell number J:132217
decreased spleen red pulp amount J:132217
enlarged lymph nodes J:132217
enlarged spleen J:132217
expanded mesangial matrix J:132217
increased anti-double stranded DNA antibody level J:132217
increased anti-histone antibody level J:132217
increased anti-nuclear antigen antibody level J:132217
increased anti-single stranded DNA antibody level J:132217
increased autoantibody level J:132217
increased dendritic cell number J:132217
increased follicular B cell number J:132217
increased immature B cell number J:132217
increased kidney cell proliferation J:132217
increased leukocyte cell number J:132217
increased macrophage cell number J:132217
increased marginal zone B cell number J:132217
increased memory T cell number J:132217
increased renal glomerulus apoptosis J:132217
increased renal glomerulus basement membrane thickness J:132217
increased spleen white pulp amount J:132217
increased susceptibility to autoimmune disorder J:132217
increased transitional stage B cell number J:132217
lymph node hyperplasia J:132217
renal glomerulus hypertrophy J:132217
spleen hyperplasia J:132217
C3tm1Crr/C3tm1Crr
C4btm1Crr/C4btm1Crr
Faslpr/Faslpr
involves: 129S4/SvJae * C57BL/6 * MRL 		abnormal immune system physiology J:127292
abnormal kidney morphology J:127292
abnormal renal glomerulus morphology J:127292
enlarged cervical lymph nodes J:127292
enlarged spleen J:127292
increased anti-double stranded DNA antibody level J:127292
increased anti-nuclear antigen antibody level J:127292
C3tm1Crr/C3tm1Crr
Faslpr/Faslpr
involves: 129S4/SvJae * C57BL/6 * MRL 		abnormal renal glomerulus morphology J:127292
decreased susceptibility to autoimmune disorder J:127292
normal immune system phenotype J:127292
C4btm1Crr/C4btm1Crr
Faslpr/Faslpr
involves: 129S4/SvJae * C57BL/6 * MRL 		abnormal immune system physiology J:127292
abnormal kidney morphology J:127292
abnormal renal glomerulus morphology J:127292
enlarged cervical lymph nodes J:127292
enlarged spleen J:127292
increased anti-double stranded DNA antibody level J:127292
increased anti-nuclear antigen antibody level J:127292
Ccr2tm1Blck/Ccr2tm1Blck
Faslpr/Faslpr
MRL.Cg-Ccr2tm1Blck Faslpr 		abnormal immune system organ morphology J:113343
abnormal interferon level J:113343
abnormal lymphocyte cell number J:113343
abnormal renal glomerulus morphology J:113343
abnormal tumor necrosis factor level J:113343
albuminuria J:113343
enlarged lymph nodes J:113343
enlarged spleen J:113343
expanded mesangial matrix J:113343
glomerulonephritis J:113343
glomerulosclerosis J:113343
kidney inflammation J:113343
premature death J:113343
renal tubule atrophy J:113343
Cd40lgtm1Flv/Cd40lgtm1Flv
Faslpr/Faslpr
involves: 129P2/OlaHsd * 129S2/SvPas * MRL 		abnormal kidney morphology J:38492
alopecia J:38492
decreased autoantibody level J:38492
decreased IgG level J:38492
decreased immunoglobulin level J:38492
extended life span J:38492
skin lesions J:38492
Cd40lgtm1Flv/Cd40lgtm1Flv
Faslpr/Faslpr
Tcratm1Mjo/Tcratm1Mjo
involves: 129P2/OlaHsd * 129S2/SvPas * MRL 		abnormal kidney morphology J:38492
decreased autoantibody level J:38492
increased anti-double stranded DNA antibody level J:38492
normal integument phenotype J:38492
Cd40lgtm1Flv/Y
Faslpr/Faslpr
involves: 129P2/OlaHsd * 129S2/SvPas * MRL 		abnormal kidney morphology J:38492
alopecia J:38492
decreased autoantibody level J:38492
decreased IgG level J:38492
decreased immunoglobulin level J:38492
extended life span J:38492
skin lesions J:38492
Cd40lgtm1Flv/Y
Faslpr/Faslpr
Tcratm1Mjo/Tcratm1Mjo
involves: 129P2/OlaHsd * 129S2/SvPas * MRL 		abnormal kidney morphology J:38492
decreased autoantibody level J:38492
increased anti-double stranded DNA antibody level J:38492
normal integument phenotype J:38492
Cd72b/Cd72b
Faslpr/Faslpr
involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp 		abnormal B cell number J:204782
abnormal renal glomerulus morphology J:204782
abnormal T cell number J:204782
abnormal urine protein level J:204782
autoimmune response J:204782
decreased anti-double stranded DNA antibody level J:204782
decreased anti-nuclear antigen antibody level J:204782
decreased IgG level J:204782
decreased spleen weight J:204782
decreased susceptibility to autoimmune disorder J:204782
renal glomerular protein deposits J:204782
Cd72c/Cd72c
Faslpr/Faslpr
involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp 		abnormal B cell number J:204782
abnormal T cell number J:204782
autoimmune response J:204782
cortical renal glomerulopathies J:204782
enlarged lymph nodes J:204782
increased anti-chromatin antibody level J:204782
increased anti-double stranded DNA antibody level J:204782
increased anti-single stranded DNA antibody level J:204782
increased IgG level J:204782
increased spleen weight J:204782
increased susceptibility to systemic lupus erythematosus J:204782
liver inflammation J:204782
lung inflammation J:204782
Cd72tm1Tsub/Cd72tm1Tsub
Faslpr/Faslpr
involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp 		abnormal B cell number J:204782
abnormal T cell number J:204782
autoimmune response J:204782
enlarged lymph nodes J:204782
glomerulonephritis J:204782
increased anti-chromatin antibody level J:204782
increased anti-double stranded DNA antibody level J:204782
increased anti-single stranded DNA antibody level J:204782
increased spleen weight J:204782
liver inflammation J:204782
lung inflammation J:204782
renal glomerular immunoglobulin deposits J:204782
Cd180tm1Kmiy/Cd180tm1Kmiy
Faslpr/Faslpr
MRL.Cg-Cd180tm1Kmiy Faslpr 		abnormal blood urea nitrogen level J:137066
blood vessel inflammation J:137066
decreased B cell number J:137066
decreased CD8-positive, alpha-beta T cell number J:137066
decreased IgG2a level J:137066
decreased IgG3 level J:137066
enlarged lymph nodes J:137066
enlarged spleen J:137066
glomerulonephritis J:137066
normal hematopoietic system phenotype J:137066
increased anti-nuclear antigen antibody level J:137066
increased autoantibody level J:137066
increased double-negative T cell number J:137066
normal mortality/aging J:137066
Dntttm1Gfn/Dntttm1Gfn
Faslpr/Faslpr
involves: 129S2/SvPas * C57BL/6 * MRL/MpJ 		decreased autoantibody level J:110248
Dsg4hage/Dsg4hage
Faslpr/Faslpr
X/Yaa
EOD-Dsg4hage 		abnormal effector T cell morphology J:140028
abnormal hair follicle morphology J:140028
abnormal hair follicle orientation J:140028
abnormal mast cell morphology J:140028
absent vibrissae J:140028
decreased body size J:140028
extended life span J:140028
sparse hair J:140028
thick epidermis J:140028
Ebi3tm1Nkma/Ebi3tm1Nkma
Faslpr/Faslpr
MRL.Cg-Ebi3tm1Nkma Faslpr 		abnormal blood homeostasis J:181669
abnormal cytokine level J:181669
abnormal glomerular capillary morphology J:181669
abnormal kidney physiology J:181669
abnormal renal protein reabsorption J:181669
decreased blood urea nitrogen level J:181669
decreased circulating creatine level J:181669
decreased circulating creatinine level J:181669
decreased circulating interferon-gamma level J:181669
increased circulating interleukin-4 level J:181669
increased IgE level J:181669
increased IgG1 level J:181669
increased IgG level J:181669
increased immunoglobulin level J:181669
increased urine protein level J:181669
premature death J:181669
Faslpr/Fas+
Raf1tm1Bacc/Raf1+
involves: 129/SvHsd * 129P2/OlaHsd * C57BL/6 * MRL 		normal hematopoietic system phenotype J:135681
Faslpr/Fas+
Raf1tm1Bacc/Raf1tm1Bacc
involves: 129/SvHsd * 129P2/OlaHsd * C57BL/6 * MRL 		abnormal erythropoiesis J:135681
normal hematopoietic system phenotype J:135681
normal mortality/aging J:135681
Faslpr/Fas+
Tg(TcraTcrb)1100Mjb/?
involves: C57BL/6 * MRL/Mp 		liver inflammation J:72817
normal liver/biliary system phenotype J:72817
normal mortality/aging J:72817
Faslpr/Faslpr
Fasltm2.1Bksa/Fasltm2.1Bksa
involves: 129 * C57BL/6 * MRL/Mp 		abnormal retina ganglion cell morphology J:171440
normal vision/eye phenotype J:171440
Faslpr/Faslpr
Fcer1gtm1Tks/Fcer1gtm1Tks
MRL.Cg-Fcer1gtm1Tks Faslpr 		abnormal glomerular capillary endothelium morphology J:106188
arteritis J:106188
decreased susceptibility to type III hypersensitivity reaction J:106188
glomerular crescent J:106188
glomerulonephritis J:106188
normal immune system phenotype J:106188
increased anti-double stranded DNA antibody level J:106188
increased double-negative T cell number J:106188
increased IgG level J:106188
increased kidney cell proliferation J:106188
increased mesangial cell number J:106188
increased spleen weight J:106188
increased urine protein level J:106188
kidney failure J:106188
premature death J:106188
vascular inflammation J:106188
Faslpr/Faslpr
Havcr1tm1Kuch/Havcr1tm1Kuch
B6.Cg-Havcr1tm1Kuch Faslpr 		abnormal immunoglobulin level J:186484
enlarged lymph nodes J:186484
enlarged spleen J:186484
increased activated T cell number J:186484
increased anti-double stranded DNA antibody level J:186484
increased autoantibody level J:186484
increased B cell number J:186484
increased CD4-positive, alpha-beta T cell number J:186484
increased CD8-positive, alpha-beta T cell number J:186484
increased double-negative T cell number J:186484
increased IgG1 level J:186484
increased IgG2a level J:186484
increased IgG2b level J:186484
increased IgG3 level J:186484
increased susceptibility to systemic lupus erythematosus J:186484
increased T cell number J:186484
Faslpr/Faslpr
Hspa13tm1.1Smoc/Hspa13tm1.1Smoc
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * 129S * C57BL/6 * MRL/Mp 		decreased autoantibody level J:303927
decreased susceptibility to systemic lupus erythematosus J:303927
increased urine protein level J:303927
Faslpr/Faslpr
Ifnar1tm1Agt/Ifnar1tm1Agt
MRL.Cg-Ifnar1tm1Agt Faslpr 		enlarged lymph nodes J:92084
glomerulonephritis J:92084
increased anti-nuclear antigen antibody level J:92084
increased autoantibody level J:92084
increased IgA level J:92084
increased IgG2b level J:92084
increased IgG3 level J:92084
increased IgG level J:92084
increased IgM level J:92084
increased susceptibility to systemic lupus erythematosus J:92084
increased urine protein level J:92084
salivary gland inflammation J:92084
Faslpr/Faslpr
Ifnar1tm1Agt/Ifnar1tm1Agt
Ifngr1tm1Agt/Ifngr1tm1Agt
MRL.Cg-Ifngr1tm1Agt Ifnar1tm1Agt Faslpr 		decreased anti-nuclear antigen antibody level J:92084
decreased autoantibody level J:92084
decreased IgG level J:92084
decreased susceptibility to systemic lupus erythematosus J:92084
glomerulonephritis J:92084
increased IgG level J:92084
increased susceptibility to systemic lupus erythematosus J:92084
increased urine protein level J:92084
salivary gland inflammation J:92084
small lymph nodes J:92084
Faslpr/Faslpr
Ifngtm1Ts/Ifng+
MRL.Cg-Ifngtm1Ts Faslpr 		abnormal glomerular capillary morphology J:123834
abnormal macrophage chemotaxis J:123834
abnormal renal glomerulus morphology J:123834
glomerulonephritis J:123834
increased autoantibody level J:123834
increased blood urea nitrogen level J:123834
increased mesangial cell number J:123834
premature death J:123834
Faslpr/Faslpr
Ifngtm1Ts/Ifngtm1Ts
involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp 		abnormal lymph node size J:39600
abnormal spleen size J:39600
decreased anti-double stranded DNA antibody level J:39600
decreased anti-nuclear antigen antibody level J:39600
decreased autoantibody level J:39600
decreased circulating creatinine level J:39600
decreased double-negative T cell number J:39600
decreased IgA level J:39600
decreased IgG2a level J:39600
decreased IgG2b level J:39600
decreased IgM level J:39600
decreased immunoglobulin level J:39600
decreased susceptibility to systemic lupus erythematosus J:39600
enlarged lymph nodes J:39600
enlarged spleen J:39600
Faslpr/Faslpr
Ifngtm1Ts/Ifngtm1Ts
MRL.Cg-Ifngtm1Ts Faslpr 		abnormal macrophage chemotaxis J:123834
abnormal renal glomerulus morphology J:123834
normal immune system phenotype J:123834
kidney inflammation J:123834
lung inflammation J:123834
Faslpr/Faslpr
Ifngr1tm1Agt/Ifngr1tm1Agt
MRL.Cg-Ifngr1tm1Agt Faslpr 		decreased anti-nuclear antigen antibody level J:92084
decreased autoantibody level J:92084
decreased IgA level J:92084
decreased IgG2a level J:92084
decreased IgG2b level J:92084
decreased IgG3 level J:92084
decreased IgM level J:92084
decreased susceptibility to systemic lupus erythematosus J:92084
glomerulonephritis J:92084
increased IgG1 level J:92084
increased IgG level J:92084
increased urine protein level J:92084
small lymph nodes J:92084
Faslpr/Faslpr
Igh-Jtm2(3H9-VDJ*)Mwg/Igh-J+
MRL.Cg-Faslpr Igh-Jtm2(3H9-VDJ*)Mwg 		abnormal B cell receptor editing J:131138
abnormal marginal zone B cell morphology J:131138
increased anti-double stranded DNA antibody level J:131138
Faslpr/Faslpr
Ighmtm1Cgn/Ighmtm1Cgn
involves: 129S2/SvPas * C57BL/6 * MRL/Mp 		abnormal humoral immune response J:119584
abnormal immunoglobulin level J:119584
arrested B cell differentiation J:119584
decreased IgM level J:119584
decreased mature B cell number J:119584
enlarged lymph nodes J:119584
increased autoantibody level J:119584
increased T cell number J:119584
increased urine protein level J:119584
Faslpr/Faslpr
Il2ratm1Dw/Il2ratm1Dw
Tg(CD2-Ccdc86)1Hfuj/?
B6.Cg-Il2ratm1Dw Faslpr Tg(CD2-Ccdc86)1Hfuj 		enlarged spleen J:151722
Faslpr/Faslpr
Il4tm1Cgn/Il4tm1Cgn
involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp 		abnormal lymph node size J:39600
abnormal spleen size J:39600
decreased anti-nuclear antigen antibody level J:39600
decreased circulating creatinine level J:39600
decreased IgA level J:39600
decreased IgE level J:39600
decreased IgG1 level J:39600
decreased IgG3 level J:39600
decreased immunoglobulin level J:39600
decreased susceptibility to systemic lupus erythematosus J:39600
enlarged spleen J:39600
increased spleen weight J:39600
spleen hyperplasia J:39600
Faslpr/Faslpr
Il4tm1Cgn/Il4tm1Cgn
MRL.Cg-Il4tm1Cgn Faslpr 		glomerulonephritis J:132514
lacrimal gland inflammation J:132514
Faslpr/Faslpr
Il27ratm1Mak/Il27ratm1Mak
MRL.Cg-Il27ratm1Mak Faslpr 		abnormal T-helper 2 physiology J:122148
decreased anti-double stranded DNA antibody level J:122148
decreased blood urea nitrogen level J:122148
decreased circulating creatinine level J:122148
decreased IgG2a level J:122148
decreased interferon-gamma secretion J:122148
decreased susceptibility to systemic lupus erythematosus J:122148
extended life span J:122148
glomerulonephritis J:122148
normal immune system phenotype J:122148
increased circulating interleukin-4 level J:122148
increased circulating interleukin-5 level J:122148
increased IgE level J:122148
increased IgG1 level J:122148
Faslpr/Faslpr
Irf1tm1Mak/Irf1+
MRL.Cg-Irf1tm1Mak Faslpr 		abnormal skin condition J:114771
glomerulonephritis J:114771
normal immune system phenotype J:114771
increased anti-double stranded DNA antibody level J:114771
increased CD4-positive, alpha-beta T cell number J:114771
increased urine protein level J:114771
premature death J:114771
Faslpr/Faslpr
Irf1tm1Mak/Irf1tm1Mak
MRL.Cg-Irf1tm1Mak Faslpr 		abnormal cell physiology J:114771
abnormal cytokine secretion J:114771
decreased anti-double stranded DNA antibody level J:114771
glomerulonephritis J:114771
normal homeostasis/metabolism phenotype J:114771
normal immune system phenotype J:114771
increased CD4-positive, alpha-beta T cell number J:114771
normal integument phenotype J:114771
premature death J:114771
Faslpr/Faslpr
Itfg2Gt(OST215121)Lex/Itfg2Gt(OST215121)Lex
involves: 129S5/SvEvBrd * C57BL/6J * MRL/Mp 		decreased B cell number J:205951
enlarged lymph nodes J:205951
enlarged spleen J:205951
increased anti-double stranded DNA antibody level J:205951
increased anti-nuclear antigen antibody level J:205951
increased double-negative T cell number J:205951
increased IgG2a level J:205951
increased IgM level J:205951
increased susceptibility to systemic lupus erythematosus J:205951
increased urine protein level J:205951
Faslpr/Faslpr
Kdelr1m1Btlr/Kdelr1m1Btlr
involves: C57BL/6J * MRL/Mp 		normal immune system phenotype J:224970
Faslpr/Faslpr
Nos2tm1Mrl/Nos2tm1Mrl
involves: 129S7/SvEvBrd * MRL 		abnormal blood homeostasis J:42666
abnormal immunoglobulin level J:42666
abnormal urine homeostasis J:42666
decreased IgG level J:42666
decreased IgM level J:42666
decreased urine nitrite level J:42666
normal immune system phenotype J:42666
Faslpr/Faslpr
Pou2af1tm1Pmt/Pou2af1tm1Pmt
involves: 129P2/OlaHsd * C57BL/6 * MRL 		abnormal renal glomerulus morphology J:125114
abnormal T cell number J:125114
autoimmune response J:125114
decreased immunoglobulin level J:125114
decreased plasma cell number J:125114
glomerular crescent J:125114
normal hematopoietic system phenotype J:125114
increased B cell number J:125114
normal mortality/aging J:125114
renal glomerulus hypertrophy J:125114
Faslpr/Faslpr
Raf1tm1Bacc/Raf1tm1Bacc
involves: 129/SvHsd * 129P2/OlaHsd * C57BL/6 * MRL 		abnormal erythropoiesis J:135681
increased apoptosis J:135681
Faslpr/Faslpr
Selptm1Bay/Selptm1Bay
MRL.Cg-Selptm1Bay Faslpr 		abnormal chemokine secretion J:127199
abnormal glomerular capillary endothelium morphology J:127199
abnormal leukocyte adhesion J:126009
abnormal renal glomerular capsule morphology J:127199
abnormal renal glomerulus morphology J:127199
dermatitis J:127199
expanded mesangial matrix J:127199
fused podocyte foot processes J:127199
glomerular crescent J:127199
glomerulonephritis J:127199
impaired leukocyte tethering or rolling J:126009
increased mesangial cell number J:127199
increased neutrophil cell number J:127199
kidney failure J:127199
podocyte foot process effacement J:127199
premature death J:127199
renal glomerular synechia J:127199
renal glomerulus fibrosis J:127199
renal necrosis J:127199
renal tubule atrophy J:127199
vascular inflammation J:127199
Faslpr/Faslpr
Selplgtm1Fur/Selplgtm1Fur
MRL.Cg-Selplgtm1Fur Faslpr 		abnormal chemokine level J:127199
dermatitis J:127199
glomerulonephritis J:127199
premature death J:127199
Faslpr/Faslpr
Sh2d1arpl/Sh2d1arpl
MRL/Mp-Faslpr Sh2d1arpl 		abnormal immune system physiology J:126261
increased anti-nuclear antigen antibody level J:126261
Faslpr/Faslpr
Spp1tm1Rit/Spp1tm1Rit
involves: 129S7/SvEvBrd * C57BL/6 * MRL/Mp 		enlarged spleen J:73396
increased anti-double stranded DNA antibody level J:73396
increased anti-single stranded DNA antibody level J:73396
increased IgA level J:73396
increased IgG1 level J:73396
increased IgG2a level J:73396
increased IgG2b level J:73396
increased IgG3 level J:73396
increased IgM level J:73396
kidney inflammation J:73396
lymph node hyperplasia J:73396
Faslpr/Faslpr
Tcratm1Mjo/Tcra+
MRL.Cg-Tcratm1Mjo Faslpr 		normal immune system phenotype J:108590
Faslpr/Faslpr
Tcratm1Mjo/Tcratm1Mjo
involves: 129P2/OlaHsd * 129S2/SvPas * MRL 		abnormal kidney morphology J:38492
decreased autoantibody level J:38492
decreased immunoglobulin level J:38492
extended life span J:38492
skin lesions J:38492
Faslpr/Faslpr
Tcratm1Mjo/Tcratm1Mjo
involves: 129P2/OlaHsd * MRL 		abnormal kidney morphology J:45448
abnormal renal glomerulus morphology J:45448
normal immune system phenotype J:26250
increased blood urea nitrogen level J:45448
increased gamma-delta intraepithelial T cell number J:26250
increased gamma-delta T cell number J:26250
increased T cell number J:26250
increased urine protein level J:45448
kidney inflammation J:45448
Faslpr/Faslpr
Tg(CD2-Foxj1)#Stlp/0
MRL.Cg-Faslpr Tg(CD2-Foxj1)#Stlp 		abnormal T cell physiology J:122222
decreased CD4-positive, alpha-beta T cell number J:122222
decreased susceptibility to systemic lupus erythematosus J:122222
enlarged lymph nodes J:122222
enlarged spleen J:122222
increased anti-nuclear antigen antibody level J:122222
increased double-negative T cell number J:122222
kidney inflammation J:122222
liver inflammation J:122222
lung inflammation J:122222
salivary gland inflammation J:122222
Faslpr/Faslpr
Tg(H2-K-Cd86)27All/0
involves: C57BL/6 * CBA * MRL/MpJ 		decreased B cell number J:112475
Faslpr/Faslpr
Tg(Ins2-Fasl)24Ach/0
NOD.Cg-Faslpr Tg(Ins2-Fasl)24Ach 		decreased susceptibility to autoimmune diabetes J:81416
Faslpr/Faslpr
Tg(INS-Il10)#Sar/0
NOD.Cg-Faslpr Tg(INS-Il10)#Sar 		increased susceptibility to autoimmune diabetes J:64051
insulitis J:64051
Faslpr/Faslpr
Tlr7tm1Flv/Y
involves: 129S1/Sv * C57BL/6 * MRL/Mp 		abnormal B cell activation J:113557
abnormal CD4-positive, alpha beta T cell morphology J:113557
abnormal lymph node size J:113557
abnormal plasmacytoid dendritic cell physiology J:113557
decreased autoantibody level J:113557
decreased double-negative T cell number J:113557
decreased IgG2a level J:113557
decreased IgG3 level J:113557
decreased spleen weight J:113557
decreased susceptibility to systemic lupus erythematosus J:113557
increased anti-chromatin antibody level J:113557
increased autoantibody level J:113557
Faslpr/Faslpr
Tlr9tm1Aki/Tlr9tm1Aki
B6.Cg-Tlr9tm1Aki Faslpr 		autoimmune response J:135036
decreased IgM level J:135036
enlarged lymph nodes J:135036
enlarged spleen J:135036
glomerulonephritis J:135036
increased double-negative T cell number J:135036
increased IgG level J:135036
increased urine protein level J:135036
premature death J:135036
renal glomerular immunoglobulin deposits J:135036
Faslpr/Faslpr
Tlr9tm1Aki/Tlr9tm1Aki
MRL.Cg-Tlr9tm1Aki Faslpr 		abnormal B cell activation J:113557
abnormal plasmacytoid dendritic cell physiology J:113557
abnormal renal glomerulus morphology J:113557
decreased autoantibody level J:113557
enlarged lymph nodes J:113557
enlarged spleen J:113557
glomerulonephritis J:113557
increased autoantibody level J:113557
increased CD4-positive, alpha-beta T cell number J:113557
increased circulating interferon-alpha level J:113557
increased double-negative T cell number J:113557
increased IgG2a level J:113557
increased IgG3 level J:113557
increased IgG level J:113557
increased susceptibility to systemic lupus erythematosus J:113557
kidney inflammation J:113557
premature death J:113557
Faslpr/Faslpr
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
involves: 129/Sv * C57BL/6 		liver inflammation J:92470
Faslpr/Faslpr
Tnfrsf9tm1Byk/Tnfrsf9tm1Byk
MRL.Cg-Tnfrsf9tm1Byk Faslpr 		abnormal kidney morphology J:126929
abnormal lacrimal gland morphology J:126929
abnormal outer ear morphology J:127197
cortical renal glomerulopathies J:127197
enlarged lymph nodes J:127197
enlarged spleen J:127197
normal hematopoietic system phenotype J:127197
increased anti-nuclear antigen antibody level J:127197
increased B-1 B cell number J:127197
increased B-2 B cell number J:127197
increased CD4-positive, alpha-beta T cell number J:126929, J:127197
increased double-negative T cell number J:126929, J:127197
increased immunoglobulin level J:127197
increased interleukin-4 secretion J:126929
increased lacrimal gland apoptosis J:126929
increased spleen germinal center number J:127197
increased susceptibility to systemic lupus erythematosus J:127197
lacrimal gland inflammation J:126929
premature death J:127197
renal glomerular protein deposits J:127197
skin lesions J:127197
Faslpr/Faslpr
Tnfrsf13cBcmd1/Tnfrsf13c+
MRL.Cg-Tnfrsf13cBcmd1 Faslpr 		decreased B cell number J:122315
decreased marginal zone B cell number J:122315
Fastm1Ach/Fastm1Ach
Krastm4Tyj/Kras+
Ptentm1Hwu/Ptentm1Hwu
involves: 129S4/SvJae 		decreased ovarian tumor incidence J:161953
Fastm1Cgn/Fastm1Cgn
Mogtm1(cre)Gkl/Mog+
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6 		decreased susceptibility to experimental autoimmune encephalomyelitis J:114741
normal immune system phenotype J:114741
Fastm1Cgn/Fastm1Cgn
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6 		decreased susceptibility to experimental autoimmune encephalomyelitis J:114741
Fastm1Osa/Fastm1Osa
Gzmatm1Simn/Gzmatm1Simn
Gzmbtm1Ley/Gzmbtm1Ley
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		increased susceptibility to parasitic infection J:81397
Fastm1Vbo/Fastm1Vbo
Tg(Ins2-cre)25Mgn/0
Tg(Ins2-HA)165Bri/0
Tg(Tcra/Tcrb)1Vbo/0
Not Specified 		increased susceptibility to autoimmune diabetes J:85985
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04/16/2024
MGI 6.23 		The Jackson Laboratory